Tags

Type your tag names separated by a space and hit enter

Staphylococcal toxins in patients with psoriasis, atopic dermatitis, and erythroderma, and in healthy control subjects.
J Am Acad Dermatol. 2005 Jul; 53(1):67-72.JA

Abstract

BACKGROUND

The aggravating role of Staphylococcus aureus superantigens is well known in atopic dermatitis (AD) but has not yet been proven in psoriasis (PS).

OBJECTIVE

We investigated the distribution of S aureus in the skin and nares of patients with AD, PS vulgaris, erythroderma, skin infections, and sepsis, and in healthy control subjects. A Staphylococcal enterotoxin test-reversed passive latex agglutination (SET-RPLAR) test was performed to determine Staphylococcal enterotoxins A, B, C, and D.

RESULTS

S aureus was cultivated from lesional skin of 22 of 25 patients with AD and 15 of 25 patients with PS. Isolated strains were toxigenic in 44% for patients with AD and in 36% for patients with PS. The activity of disease in AD and PS according to the Severity Scoring of Atopic Dermatitis (SCORAD) or Psoriasis Area and Severity Index score, respectively, correlated significantly (P = .001) with an isolated toxigenic strain in both diseases. S aureus from skin infections was toxigenic in half of the patients. All patients with erythroderma harbored S aureus, mostly on their skin. In AD, sepsis and skin infections, toxin C and in PS toxin B was most often detected. S aureus was cultured in 12% of healthy persons. These strains were toxin negative. The limitations of these investigations are that other potentially acting enterotoxins, such as toxic shock syndrome toxin-1, which may play a role in aggravating disease, were not investigated with our latex agglutination test.

CONCLUSION

In this study, S aureus was present in more than 50% of patients with AD and PS. We found that the severity of AD and PS significantly correlated to enterotoxin production of the isolated S aureus strains.

Authors+Show Affiliations

Department of Environmental Dermatology and Sexually Transmitted Diseases, Medical University Graz, Austria.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15965423

Citation

Tomi, Nordwig Sebastian, et al. "Staphylococcal Toxins in Patients With Psoriasis, Atopic Dermatitis, and Erythroderma, and in Healthy Control Subjects." Journal of the American Academy of Dermatology, vol. 53, no. 1, 2005, pp. 67-72.
Tomi NS, Kränke B, Aberer E. Staphylococcal toxins in patients with psoriasis, atopic dermatitis, and erythroderma, and in healthy control subjects. J Am Acad Dermatol. 2005;53(1):67-72.
Tomi, N. S., Kränke, B., & Aberer, E. (2005). Staphylococcal toxins in patients with psoriasis, atopic dermatitis, and erythroderma, and in healthy control subjects. Journal of the American Academy of Dermatology, 53(1), 67-72.
Tomi NS, Kränke B, Aberer E. Staphylococcal Toxins in Patients With Psoriasis, Atopic Dermatitis, and Erythroderma, and in Healthy Control Subjects. J Am Acad Dermatol. 2005;53(1):67-72. PubMed PMID: 15965423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Staphylococcal toxins in patients with psoriasis, atopic dermatitis, and erythroderma, and in healthy control subjects. AU - Tomi,Nordwig Sebastian, AU - Kränke,Birger, AU - Aberer,Elisabeth, PY - 2005/6/21/pubmed PY - 2006/5/5/medline PY - 2005/6/21/entrez SP - 67 EP - 72 JF - Journal of the American Academy of Dermatology JO - J Am Acad Dermatol VL - 53 IS - 1 N2 - BACKGROUND: The aggravating role of Staphylococcus aureus superantigens is well known in atopic dermatitis (AD) but has not yet been proven in psoriasis (PS). OBJECTIVE: We investigated the distribution of S aureus in the skin and nares of patients with AD, PS vulgaris, erythroderma, skin infections, and sepsis, and in healthy control subjects. A Staphylococcal enterotoxin test-reversed passive latex agglutination (SET-RPLAR) test was performed to determine Staphylococcal enterotoxins A, B, C, and D. RESULTS: S aureus was cultivated from lesional skin of 22 of 25 patients with AD and 15 of 25 patients with PS. Isolated strains were toxigenic in 44% for patients with AD and in 36% for patients with PS. The activity of disease in AD and PS according to the Severity Scoring of Atopic Dermatitis (SCORAD) or Psoriasis Area and Severity Index score, respectively, correlated significantly (P = .001) with an isolated toxigenic strain in both diseases. S aureus from skin infections was toxigenic in half of the patients. All patients with erythroderma harbored S aureus, mostly on their skin. In AD, sepsis and skin infections, toxin C and in PS toxin B was most often detected. S aureus was cultured in 12% of healthy persons. These strains were toxin negative. The limitations of these investigations are that other potentially acting enterotoxins, such as toxic shock syndrome toxin-1, which may play a role in aggravating disease, were not investigated with our latex agglutination test. CONCLUSION: In this study, S aureus was present in more than 50% of patients with AD and PS. We found that the severity of AD and PS significantly correlated to enterotoxin production of the isolated S aureus strains. SN - 1097-6787 UR - https://www.unboundmedicine.com/medline/citation/15965423/Staphylococcal_toxins_in_patients_with_psoriasis_atopic_dermatitis_and_erythroderma_and_in_healthy_control_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190962205007164 DB - PRIME DP - Unbound Medicine ER -