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Relationship between vasodilation capacity and phenolic content of Spanish wines.
Eur J Pharmacol. 2005 Jul 04; 517(1-2):84-91.EJ

Abstract

We aimed to determine: 1) the concentration of polyphenols in Spanish red wines, 2) the vasodilatory properties of those wines in relation with their polyphenol concentrations and 3) the vasodilation induced by some of these polyphenols in rat aortic rings. In the wines studied the concentration of rutin and kaempferol was high compared with other polyphenols. All wines relaxed precontracted rat aortic rings and this effect was directly related with the concentration of myricetin and kaempferol in the wines. Kaempferol and rutin also induced endothelium-dependent and independent relaxation, kaempferol was more potent. This relaxation was not inhibited by the estrogen receptor alpha antagonist ICI 182,760. Kaempferol also potentiated the endothelium-dependent relaxation induced by acetylcholine, which was reversed by Nw-nitro-l-arginine methyl ester (l-NAME). These findings show a good correlation between the concentration of polyphenols (especially kaempferol) of Spanish red wines and the vasodilatory effect, which may confer on them unique features in the prevention of cardiovascular disease.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15967426

Citation

Padilla, Eugenia, et al. "Relationship Between Vasodilation Capacity and Phenolic Content of Spanish Wines." European Journal of Pharmacology, vol. 517, no. 1-2, 2005, pp. 84-91.
Padilla E, Ruiz E, Redondo S, et al. Relationship between vasodilation capacity and phenolic content of Spanish wines. Eur J Pharmacol. 2005;517(1-2):84-91.
Padilla, E., Ruiz, E., Redondo, S., Gordillo-Moscoso, A., Slowing, K., & Tejerina, T. (2005). Relationship between vasodilation capacity and phenolic content of Spanish wines. European Journal of Pharmacology, 517(1-2), 84-91.
Padilla E, et al. Relationship Between Vasodilation Capacity and Phenolic Content of Spanish Wines. Eur J Pharmacol. 2005 Jul 4;517(1-2):84-91. PubMed PMID: 15967426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between vasodilation capacity and phenolic content of Spanish wines. AU - Padilla,Eugenia, AU - Ruiz,Emilio, AU - Redondo,Santiago, AU - Gordillo-Moscoso,Antonio, AU - Slowing,Karla, AU - Tejerina,Teresa, PY - 2005/01/24/received PY - 2005/04/20/revised PY - 2005/04/29/accepted PY - 2005/6/22/pubmed PY - 2005/9/20/medline PY - 2005/6/22/entrez SP - 84 EP - 91 JF - European journal of pharmacology JO - Eur. J. Pharmacol. VL - 517 IS - 1-2 N2 - We aimed to determine: 1) the concentration of polyphenols in Spanish red wines, 2) the vasodilatory properties of those wines in relation with their polyphenol concentrations and 3) the vasodilation induced by some of these polyphenols in rat aortic rings. In the wines studied the concentration of rutin and kaempferol was high compared with other polyphenols. All wines relaxed precontracted rat aortic rings and this effect was directly related with the concentration of myricetin and kaempferol in the wines. Kaempferol and rutin also induced endothelium-dependent and independent relaxation, kaempferol was more potent. This relaxation was not inhibited by the estrogen receptor alpha antagonist ICI 182,760. Kaempferol also potentiated the endothelium-dependent relaxation induced by acetylcholine, which was reversed by Nw-nitro-l-arginine methyl ester (l-NAME). These findings show a good correlation between the concentration of polyphenols (especially kaempferol) of Spanish red wines and the vasodilatory effect, which may confer on them unique features in the prevention of cardiovascular disease. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/15967426/Relationship_between_vasodilation_capacity_and_phenolic_content_of_Spanish_wines_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(05)00499-1 DB - PRIME DP - Unbound Medicine ER -