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Brain oscillatory responses to an auditory-verbal working memory task in mild cognitive impairment and Alzheimer's disease.
Int J Psychophysiol. 2006 Feb; 59(2):168-78.IJ

Abstract

We report preliminary findings on EEG oscillatory correlates of working memory in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Event-related desynchronization (ERD) and synchronization (ERS) of the 1-20 Hz EEG frequencies were studied using wavelet transforms in elderly controls, MCI patients and mild probable AD patients performing an auditory-verbal Sternberg memory task. Behaviourally, the AD patients made more errors than the controls and the MCI group. Statistically significant differences during the encoding of the memory set were found between the controls and the MCI group, such that the latter group showed ERD in the approximately 10-20 Hz frequencies. The findings may reflect different, compensatory encoding strategies in MCI. During retrieval, the most obvious differences were observed between the controls and the AD group: the ERD in the approximately 7-17 Hz frequencies was absent in the AD group particularly in anterior and left temporal electrode locations. This finding might indicate that AD is associated with deficient lexical-semantic processing during the retrieval phase in working memory tasks. Future studies with larger patient groups are needed to establish the diagnostic value of ERD/ERS patterns in MCI and AD.

Authors+Show Affiliations

Department of Psychology, Abo Akademi University, FIN-20500, Abo, Finland. mira.karrasch@abo.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15967527

Citation

Karrasch, Mira, et al. "Brain Oscillatory Responses to an Auditory-verbal Working Memory Task in Mild Cognitive Impairment and Alzheimer's Disease." International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology, vol. 59, no. 2, 2006, pp. 168-78.
Karrasch M, Laine M, Rinne JO, et al. Brain oscillatory responses to an auditory-verbal working memory task in mild cognitive impairment and Alzheimer's disease. Int J Psychophysiol. 2006;59(2):168-78.
Karrasch, M., Laine, M., Rinne, J. O., Rapinoja, P., Sinervä, E., & Krause, C. M. (2006). Brain oscillatory responses to an auditory-verbal working memory task in mild cognitive impairment and Alzheimer's disease. International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology, 59(2), 168-78.
Karrasch M, et al. Brain Oscillatory Responses to an Auditory-verbal Working Memory Task in Mild Cognitive Impairment and Alzheimer's Disease. Int J Psychophysiol. 2006;59(2):168-78. PubMed PMID: 15967527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain oscillatory responses to an auditory-verbal working memory task in mild cognitive impairment and Alzheimer's disease. AU - Karrasch,Mira, AU - Laine,Matti, AU - Rinne,Juha O, AU - Rapinoja,Pekka, AU - Sinervä,Eija, AU - Krause,Christina M, Y1 - 2005/06/20/ PY - 2004/12/09/received PY - 2005/04/04/revised PY - 2005/04/26/accepted PY - 2005/6/22/pubmed PY - 2006/4/14/medline PY - 2005/6/22/entrez SP - 168 EP - 78 JF - International journal of psychophysiology : official journal of the International Organization of Psychophysiology JO - Int J Psychophysiol VL - 59 IS - 2 N2 - We report preliminary findings on EEG oscillatory correlates of working memory in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Event-related desynchronization (ERD) and synchronization (ERS) of the 1-20 Hz EEG frequencies were studied using wavelet transforms in elderly controls, MCI patients and mild probable AD patients performing an auditory-verbal Sternberg memory task. Behaviourally, the AD patients made more errors than the controls and the MCI group. Statistically significant differences during the encoding of the memory set were found between the controls and the MCI group, such that the latter group showed ERD in the approximately 10-20 Hz frequencies. The findings may reflect different, compensatory encoding strategies in MCI. During retrieval, the most obvious differences were observed between the controls and the AD group: the ERD in the approximately 7-17 Hz frequencies was absent in the AD group particularly in anterior and left temporal electrode locations. This finding might indicate that AD is associated with deficient lexical-semantic processing during the retrieval phase in working memory tasks. Future studies with larger patient groups are needed to establish the diagnostic value of ERD/ERS patterns in MCI and AD. SN - 0167-8760 UR - https://www.unboundmedicine.com/medline/citation/15967527/Brain_oscillatory_responses_to_an_auditory_verbal_working_memory_task_in_mild_cognitive_impairment_and_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-8760(05)00128-5 DB - PRIME DP - Unbound Medicine ER -