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Antioxidant activity of isocytisoside and extracts of Aquilegia vulgaris.
Fitoterapia. 2005 Jul; 76(5):476-80.F

Abstract

Two extracts (ethyl acetate and ethanol) and isocytisoside obtained from Aquilegia vulgaris were tested for their antioxidant and free radical scavenging activity in vitro. Inhibition both non-enzymatic (IC50: 150-219 microg/ml) and enzymatic (IC50: 23-60 microg/ml) microsomal lipid peroxidation was observed, the extracts being more active than isocytisoside. The substances tested appeared to be weak hydroxyl radical scavengers, showed very low TEAC values and moderate iron chelation ability. However, all preparations at the concentration 25 microg/ml inhibited superoxide anion formation at the range 47-68%. Despite of the lack of a potent free radical scavenging ability the substances tested demonstrated significant antioxidant activity. Relationship between this parameter and the content of phenolic groups was noticed.

Authors+Show Affiliations

Department of Toxicology, Poznañ University of Medical Sciences, Dojazd 30, 60-631 Poznañ, Poland. marek.murias@amp.edu.plNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15967592

Citation

Murias, Marek, et al. "Antioxidant Activity of Isocytisoside and Extracts of Aquilegia Vulgaris." Fitoterapia, vol. 76, no. 5, 2005, pp. 476-80.
Murias M, Jodynis-Liebert J, Matławska I, et al. Antioxidant activity of isocytisoside and extracts of Aquilegia vulgaris. Fitoterapia. 2005;76(5):476-80.
Murias, M., Jodynis-Liebert, J., Matławska, I., & Bylka, W. (2005). Antioxidant activity of isocytisoside and extracts of Aquilegia vulgaris. Fitoterapia, 76(5), 476-80.
Murias M, et al. Antioxidant Activity of Isocytisoside and Extracts of Aquilegia Vulgaris. Fitoterapia. 2005;76(5):476-80. PubMed PMID: 15967592.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant activity of isocytisoside and extracts of Aquilegia vulgaris. AU - Murias,Marek, AU - Jodynis-Liebert,Jadwiga, AU - Matławska,Irena, AU - Bylka,Wiesława, PY - 2004/08/02/received PY - 2005/04/26/accepted PY - 2005/6/22/pubmed PY - 2005/9/2/medline PY - 2005/6/22/entrez SP - 476 EP - 80 JF - Fitoterapia JO - Fitoterapia VL - 76 IS - 5 N2 - Two extracts (ethyl acetate and ethanol) and isocytisoside obtained from Aquilegia vulgaris were tested for their antioxidant and free radical scavenging activity in vitro. Inhibition both non-enzymatic (IC50: 150-219 microg/ml) and enzymatic (IC50: 23-60 microg/ml) microsomal lipid peroxidation was observed, the extracts being more active than isocytisoside. The substances tested appeared to be weak hydroxyl radical scavengers, showed very low TEAC values and moderate iron chelation ability. However, all preparations at the concentration 25 microg/ml inhibited superoxide anion formation at the range 47-68%. Despite of the lack of a potent free radical scavenging ability the substances tested demonstrated significant antioxidant activity. Relationship between this parameter and the content of phenolic groups was noticed. SN - 0367-326X UR - https://www.unboundmedicine.com/medline/citation/15967592/Antioxidant_activity_of_isocytisoside_and_extracts_of_Aquilegia_vulgaris_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(05)00095-X DB - PRIME DP - Unbound Medicine ER -