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Psychopathology in children and adolescents with Tourette's syndrome: a controlled study.
Brain Dev. 2006 Mar; 28(2):69-75.BD

Abstract

OBJECTIVE

Few controlled studies have considered, in paediatric subjects, associations between Tourette's syndrome (TS) and psychiatric/behavioural disorders. We conducted a case-control study to verify the reproducibility of the few data published on this topic to date.

METHOD

Clinicians' impression (i.e. structured interviews and usual history taking), standardized psychiatric and behavioural rating scales (CBCL, TAI, CDI, CRS-R:L, Y-GTSS, CY-BOCS) were used to investigate these associations in 17 youngsters with TS and in 17 age- and sex-matched controls.

RESULTS

The clinician's diagnoses revealed TS alone in 23.5% of the patients (4/17), TS plus attention-deficit/hyperactivity disorder (ADHD) in 11.8% (2/17), TS plus obsessive-compulsive disorder (OCD) in 41.2% (7/17), and TS plus ADHD and OCD in 23.5% (4/17). No control subject presented ADHD and/or OCD. These clinical findings were confirmed by Child Behaviour Check List (CBCL) results. The TS group, compared with the controls, recorded significantly higher CBCL scores in scales relating to the main comorbid conditions. No significant differences emerged on the Children's Depression Inventory or Test Anxiety Inventory.

CONCLUSION

TS patients have a high prevalence of psychiatric and behavioural problems compared with controls. The CBCL is a rapid and useful screening-diagnostic instrument for highlighting the main psychiatric and behavioural problems in TS.

Authors+Show Affiliations

Child Neuropsychiatry Unit, Department of Clinical and Biological Sciences, University of Insubria, Via F. del Ponte 19, 21100 Varese, Italy. critermine@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15967616

Citation

Termine, Cristiano, et al. "Psychopathology in Children and Adolescents With Tourette's Syndrome: a Controlled Study." Brain & Development, vol. 28, no. 2, 2006, pp. 69-75.
Termine C, Balottin U, Rossi G, et al. Psychopathology in children and adolescents with Tourette's syndrome: a controlled study. Brain Dev. 2006;28(2):69-75.
Termine, C., Balottin, U., Rossi, G., Maisano, F., Salini, S., Di Nardo, R., & Lanzi, G. (2006). Psychopathology in children and adolescents with Tourette's syndrome: a controlled study. Brain & Development, 28(2), 69-75.
Termine C, et al. Psychopathology in Children and Adolescents With Tourette's Syndrome: a Controlled Study. Brain Dev. 2006;28(2):69-75. PubMed PMID: 15967616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Psychopathology in children and adolescents with Tourette's syndrome: a controlled study. AU - Termine,Cristiano, AU - Balottin,Umberto, AU - Rossi,Giorgio, AU - Maisano,Francesca, AU - Salini,Silvia, AU - Di Nardo,Roberta, AU - Lanzi,Giovanni, Y1 - 2005/06/20/ PY - 2004/10/26/received PY - 2005/04/11/revised PY - 2005/04/13/accepted PY - 2005/6/22/pubmed PY - 2006/5/26/medline PY - 2005/6/22/entrez SP - 69 EP - 75 JF - Brain & development JO - Brain Dev VL - 28 IS - 2 N2 - OBJECTIVE: Few controlled studies have considered, in paediatric subjects, associations between Tourette's syndrome (TS) and psychiatric/behavioural disorders. We conducted a case-control study to verify the reproducibility of the few data published on this topic to date. METHOD: Clinicians' impression (i.e. structured interviews and usual history taking), standardized psychiatric and behavioural rating scales (CBCL, TAI, CDI, CRS-R:L, Y-GTSS, CY-BOCS) were used to investigate these associations in 17 youngsters with TS and in 17 age- and sex-matched controls. RESULTS: The clinician's diagnoses revealed TS alone in 23.5% of the patients (4/17), TS plus attention-deficit/hyperactivity disorder (ADHD) in 11.8% (2/17), TS plus obsessive-compulsive disorder (OCD) in 41.2% (7/17), and TS plus ADHD and OCD in 23.5% (4/17). No control subject presented ADHD and/or OCD. These clinical findings were confirmed by Child Behaviour Check List (CBCL) results. The TS group, compared with the controls, recorded significantly higher CBCL scores in scales relating to the main comorbid conditions. No significant differences emerged on the Children's Depression Inventory or Test Anxiety Inventory. CONCLUSION: TS patients have a high prevalence of psychiatric and behavioural problems compared with controls. The CBCL is a rapid and useful screening-diagnostic instrument for highlighting the main psychiatric and behavioural problems in TS. SN - 0387-7604 UR - https://www.unboundmedicine.com/medline/citation/15967616/Psychopathology_in_children_and_adolescents_with_Tourette's_syndrome:_a_controlled_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0387-7604(05)00084-7 DB - PRIME DP - Unbound Medicine ER -