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Distribution and frequency of endocrine cells in the pancreas of the ddY mouse: an immunohistochemical study.
Eur J Histochem. 2005 Apr-Jun; 49(2):125-30.EJ

Abstract

The regional distribution and frequency of pancreatic endocrine cells in ddY mice were studied by an immunohistochemical (peroxidase anti-peroxidase; PAP) method using four types of specific antisera against insulin, glucagon, somatostatin and human pancreatic polypeptide (hPP). In the pancreatic islets, most of insulin-immunoreactive (IR) cells were located in the central portion. Most of glucagon- and somatostatin-IR cells were observed in peripheral regions although a somewhat smaller number of cells were also located in the central regions. HPP-IR cells were randomly distributed throughout the entire islets. In the exocrine pancreas, insulin-, glucagon-, somatostatin- and hPP-IR cells were detected; they occurred mainly among the exocrine parenchyma as solitary cells. Cell clusters consisted of only insulin- or only glucagon-IR cells and were distributed in the pancreas parenchyma as small islets. In addition, insulin- and glucagon-IR cells were also demonstrated in the pancreatic duct regions. Insulin-IR cells were located in the epithelium and sub-epithelial connective tissue regions as solitary cells and/or clusters (3-4 cells), and glucagon-IR cells were mainly located in the epithelium as solitary cells. Overall, there were 63.89+/-5.39% insulin-, 26.52+/-3.55% glucagon-, 7.25+/-2.83% somatostatin- and 1.90+/-0.58% hPP-IR cells. In conclusion, some strain-dependent characteristic distributional patterns of pancreatic endocrine cells were found in the ddY mouse.

Authors+Show Affiliations

Pharmacology & Toxicology Laboratory, Central Research Laboratories, Dong-Wha Pharm. Ind. Co., Anyang, South Korea.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15967740

Citation

Ku, S K., and H S. Lee. "Distribution and Frequency of Endocrine Cells in the Pancreas of the ddY Mouse: an Immunohistochemical Study." European Journal of Histochemistry : EJH, vol. 49, no. 2, 2005, pp. 125-30.
Ku SK, Lee HS. Distribution and frequency of endocrine cells in the pancreas of the ddY mouse: an immunohistochemical study. Eur J Histochem. 2005;49(2):125-30.
Ku, S. K., & Lee, H. S. (2005). Distribution and frequency of endocrine cells in the pancreas of the ddY mouse: an immunohistochemical study. European Journal of Histochemistry : EJH, 49(2), 125-30.
Ku SK, Lee HS. Distribution and Frequency of Endocrine Cells in the Pancreas of the ddY Mouse: an Immunohistochemical Study. Eur J Histochem. 2005 Apr-Jun;49(2):125-30. PubMed PMID: 15967740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Distribution and frequency of endocrine cells in the pancreas of the ddY mouse: an immunohistochemical study. AU - Ku,S K, AU - Lee,H S, PY - 2005/6/22/pubmed PY - 2005/12/13/medline PY - 2005/6/22/entrez SP - 125 EP - 30 JF - European journal of histochemistry : EJH JO - Eur J Histochem VL - 49 IS - 2 N2 - The regional distribution and frequency of pancreatic endocrine cells in ddY mice were studied by an immunohistochemical (peroxidase anti-peroxidase; PAP) method using four types of specific antisera against insulin, glucagon, somatostatin and human pancreatic polypeptide (hPP). In the pancreatic islets, most of insulin-immunoreactive (IR) cells were located in the central portion. Most of glucagon- and somatostatin-IR cells were observed in peripheral regions although a somewhat smaller number of cells were also located in the central regions. HPP-IR cells were randomly distributed throughout the entire islets. In the exocrine pancreas, insulin-, glucagon-, somatostatin- and hPP-IR cells were detected; they occurred mainly among the exocrine parenchyma as solitary cells. Cell clusters consisted of only insulin- or only glucagon-IR cells and were distributed in the pancreas parenchyma as small islets. In addition, insulin- and glucagon-IR cells were also demonstrated in the pancreatic duct regions. Insulin-IR cells were located in the epithelium and sub-epithelial connective tissue regions as solitary cells and/or clusters (3-4 cells), and glucagon-IR cells were mainly located in the epithelium as solitary cells. Overall, there were 63.89+/-5.39% insulin-, 26.52+/-3.55% glucagon-, 7.25+/-2.83% somatostatin- and 1.90+/-0.58% hPP-IR cells. In conclusion, some strain-dependent characteristic distributional patterns of pancreatic endocrine cells were found in the ddY mouse. SN - 1121-760X UR - https://www.unboundmedicine.com/medline/citation/15967740/Distribution_and_frequency_of_endocrine_cells_in_the_pancreas_of_the_ddY_mouse:_an_immunohistochemical_study_ L2 - https://antibodies.cancer.gov/detail/CPTC-ASAP1-1 DB - PRIME DP - Unbound Medicine ER -