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Erythrocyte aldehyde dehydrogenase activity: lack of association with alcohol use and dependence or alcohol reactions in Australian twins.
Alcohol Alcohol. 2005 Sep-Oct; 40(5):343-8.AA

Abstract

AIM

Aldehyde dehydrogenase 1 (ALDH1) has been advocated as a marker of alcohol intake. The absence or low levels of ALDH1 may be associated with alcohol-induced flushing or other reactions to alcohol in Europeans and therefore, with reduced alcohol use. This study tested whether variation in erythrocyte ALDH1 activity was associated with alcohol use, alcohol dependence or reactions to alcohol in unselected subjects of European descent, and whether variation in ALDH1 activity was subject to genetic influences.

METHODS

ALDH activity was measured in erythrocytes from 677 men and women who had participated in a twin study of alcohol use and dependence.

RESULTS

There were no significant effects of sex, alcohol consumption or alcohol dependence on ALDH activity. Subjects who reported reactions to alcohol did not have low activity. Women aged below 45 years had lower ALDH activity than men or older women. The heritability of ALDH activity was 56% (95% confidence interval = 42-67%).

CONCLUSIONS

Previous reports that erythrocyte ALDH activity is low in alcoholics were not substantiated in this community-based sample. Associations with alcohol reactions were not found. ALDH activity varies widely between subjects, largely because of genetic factors.

Authors+Show Affiliations

The Queensland Institute of Medical Research, Brisbane, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15967764

Citation

Hansell, Narelle K., et al. "Erythrocyte Aldehyde Dehydrogenase Activity: Lack of Association With Alcohol Use and Dependence or Alcohol Reactions in Australian Twins." Alcohol and Alcoholism (Oxford, Oxfordshire), vol. 40, no. 5, 2005, pp. 343-8.
Hansell NK, Pang D, Heath AC, et al. Erythrocyte aldehyde dehydrogenase activity: lack of association with alcohol use and dependence or alcohol reactions in Australian twins. Alcohol Alcohol. 2005;40(5):343-8.
Hansell, N. K., Pang, D., Heath, A. C., Martin, N. G., & Whitfield, J. B. (2005). Erythrocyte aldehyde dehydrogenase activity: lack of association with alcohol use and dependence or alcohol reactions in Australian twins. Alcohol and Alcoholism (Oxford, Oxfordshire), 40(5), 343-8.
Hansell NK, et al. Erythrocyte Aldehyde Dehydrogenase Activity: Lack of Association With Alcohol Use and Dependence or Alcohol Reactions in Australian Twins. Alcohol Alcohol. 2005 Sep-Oct;40(5):343-8. PubMed PMID: 15967764.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Erythrocyte aldehyde dehydrogenase activity: lack of association with alcohol use and dependence or alcohol reactions in Australian twins. AU - Hansell,Narelle K, AU - Pang,Dona, AU - Heath,Andrew C, AU - Martin,Nicholas G, AU - Whitfield,John B, Y1 - 2005/06/20/ PY - 2005/6/22/pubmed PY - 2006/1/13/medline PY - 2005/6/22/entrez SP - 343 EP - 8 JF - Alcohol and alcoholism (Oxford, Oxfordshire) JO - Alcohol Alcohol VL - 40 IS - 5 N2 - AIM: Aldehyde dehydrogenase 1 (ALDH1) has been advocated as a marker of alcohol intake. The absence or low levels of ALDH1 may be associated with alcohol-induced flushing or other reactions to alcohol in Europeans and therefore, with reduced alcohol use. This study tested whether variation in erythrocyte ALDH1 activity was associated with alcohol use, alcohol dependence or reactions to alcohol in unselected subjects of European descent, and whether variation in ALDH1 activity was subject to genetic influences. METHODS: ALDH activity was measured in erythrocytes from 677 men and women who had participated in a twin study of alcohol use and dependence. RESULTS: There were no significant effects of sex, alcohol consumption or alcohol dependence on ALDH activity. Subjects who reported reactions to alcohol did not have low activity. Women aged below 45 years had lower ALDH activity than men or older women. The heritability of ALDH activity was 56% (95% confidence interval = 42-67%). CONCLUSIONS: Previous reports that erythrocyte ALDH activity is low in alcoholics were not substantiated in this community-based sample. Associations with alcohol reactions were not found. ALDH activity varies widely between subjects, largely because of genetic factors. SN - 0735-0414 UR - https://www.unboundmedicine.com/medline/citation/15967764/Erythrocyte_aldehyde_dehydrogenase_activity:_lack_of_association_with_alcohol_use_and_dependence_or_alcohol_reactions_in_Australian_twins_ L2 - https://academic.oup.com/alcalc/article-lookup/doi/10.1093/alcalc/agh168 DB - PRIME DP - Unbound Medicine ER -