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Visceral fat as a determinant of fibrinolysis and hemostasis.
Semin Vasc Med 2005; 5(1):48-55SV

Abstract

An increased amount of deep abdominal visceral fat has generally been accepted as an important cardiovascular risk factor, and disturbances in hemostasis and fibrinolysis have been suggested to play a role. Fibrinogen and von Willebrand factor, representatives of the hemostatic system, and plasminogen activator inhibitor 1 (PAI-1), as the most important inhibitor of the fibrinolytic system, have been associated with visceral obesity, with the most convincing evidence found for the involvement of PAI-1. The association with fibrinogen and von Willebrand factor has been suggested to be merely a reflection of the association with inflammation and endothelial dysfunction. The fact that PAI-1 is secreted by adipose tissue has attracted much attention. The increase of PAI-1 in visceral obesity could be because visceral adipose tissue produces more PAI-1 compared with subcutaneous abdominal adipose tissue. The contribution of other cell types such as hepatocytes or endothelial cells is probably more important, with stimulation of PAI-1 production by different components of the metabolic syndrome. PAI-1 secretion by adipose tissue has been suggested to have a more local effect, playing a role in tissue remodeling during the development of obesity.

Authors+Show Affiliations

Department of Diabetology, Metabolism and Clinical Nutrition, Faculty of Medicine, Antwerp University Hospital, University of Antwerp, Antwerp, Belgium.No affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Review

Language

eng

PubMed ID

15968580

Citation

Mertens, Ilse, and Luc F. Van Gaal. "Visceral Fat as a Determinant of Fibrinolysis and Hemostasis." Seminars in Vascular Medicine, vol. 5, no. 1, 2005, pp. 48-55.
Mertens I, Van Gaal LF. Visceral fat as a determinant of fibrinolysis and hemostasis. Semin Vasc Med. 2005;5(1):48-55.
Mertens, I., & Van Gaal, L. F. (2005). Visceral fat as a determinant of fibrinolysis and hemostasis. Seminars in Vascular Medicine, 5(1), pp. 48-55.
Mertens I, Van Gaal LF. Visceral Fat as a Determinant of Fibrinolysis and Hemostasis. Semin Vasc Med. 2005;5(1):48-55. PubMed PMID: 15968580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Visceral fat as a determinant of fibrinolysis and hemostasis. AU - Mertens,Ilse, AU - Van Gaal,Luc F, PY - 2005/6/22/pubmed PY - 2005/9/1/medline PY - 2005/6/22/entrez SP - 48 EP - 55 JF - Seminars in vascular medicine JO - Semin Vasc Med VL - 5 IS - 1 N2 - An increased amount of deep abdominal visceral fat has generally been accepted as an important cardiovascular risk factor, and disturbances in hemostasis and fibrinolysis have been suggested to play a role. Fibrinogen and von Willebrand factor, representatives of the hemostatic system, and plasminogen activator inhibitor 1 (PAI-1), as the most important inhibitor of the fibrinolytic system, have been associated with visceral obesity, with the most convincing evidence found for the involvement of PAI-1. The association with fibrinogen and von Willebrand factor has been suggested to be merely a reflection of the association with inflammation and endothelial dysfunction. The fact that PAI-1 is secreted by adipose tissue has attracted much attention. The increase of PAI-1 in visceral obesity could be because visceral adipose tissue produces more PAI-1 compared with subcutaneous abdominal adipose tissue. The contribution of other cell types such as hepatocytes or endothelial cells is probably more important, with stimulation of PAI-1 production by different components of the metabolic syndrome. PAI-1 secretion by adipose tissue has been suggested to have a more local effect, playing a role in tissue remodeling during the development of obesity. SN - 1528-9648 UR - https://www.unboundmedicine.com/medline/citation/15968580/Visceral_fat_as_a_determinant_of_fibrinolysis_and_hemostasis_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=15968580.ui DB - PRIME DP - Unbound Medicine ER -