Tags

Type your tag names separated by a space and hit enter

Treatment of Sydenham's chorea with intravenous immunoglobulin, plasma exchange, or prednisone.
J Child Neurol. 2005 May; 20(5):424-9.JC

Abstract

Sydenham's chorea has been established as a postinfectious autoimmune neuropsychiatric disorder. Corticosteroids have been used to treat patients with severe disease but are not always effective, and relapses are frequent after cessation. Eighteen subjects were entered into this randomized-entry controlled trial designed to determine if intravenous immunoglobulin or plasma exchange would be superior to prednisone in decreasing the severity of chorea. Mean chorea severity for the entire group was significantly lower at the 1-month follow-up evaluation (overall 48% improvement). Although the between-group differences were not statistically significant, clinical improvements appeared to be more rapid and robust in the intravenous immunoglobulin and plasma exchange groups than in the prednisone group (mean chorea severity scores decreased by 72% in the intravenous immunoglobulin group, 50% in the plasma exchange group, and 29% in the prednisone group). Larger studies are required to confirm these clinical observations and to determine if these treatments are cost-effective for this disorder.

Authors+Show Affiliations

Pediatric and Developmental Neuropsychiatry Branch, National Institute of Mental Health, 10 Center Drive, Room 4N208, MSC 1255, Bethesda, MD 20892-1255, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

15968928

Citation

Garvey, Marjorie A., et al. "Treatment of Sydenham's Chorea With Intravenous Immunoglobulin, Plasma Exchange, or Prednisone." Journal of Child Neurology, vol. 20, no. 5, 2005, pp. 424-9.
Garvey MA, Snider LA, Leitman SF, et al. Treatment of Sydenham's chorea with intravenous immunoglobulin, plasma exchange, or prednisone. J Child Neurol. 2005;20(5):424-9.
Garvey, M. A., Snider, L. A., Leitman, S. F., Werden, R., & Swedo, S. E. (2005). Treatment of Sydenham's chorea with intravenous immunoglobulin, plasma exchange, or prednisone. Journal of Child Neurology, 20(5), 424-9.
Garvey MA, et al. Treatment of Sydenham's Chorea With Intravenous Immunoglobulin, Plasma Exchange, or Prednisone. J Child Neurol. 2005;20(5):424-9. PubMed PMID: 15968928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of Sydenham's chorea with intravenous immunoglobulin, plasma exchange, or prednisone. AU - Garvey,Marjorie A, AU - Snider,Lisa A, AU - Leitman,Susan F, AU - Werden,Rose, AU - Swedo,Susan E, PY - 2005/6/23/pubmed PY - 2005/8/5/medline PY - 2005/6/23/entrez SP - 424 EP - 9 JF - Journal of child neurology JO - J Child Neurol VL - 20 IS - 5 N2 - Sydenham's chorea has been established as a postinfectious autoimmune neuropsychiatric disorder. Corticosteroids have been used to treat patients with severe disease but are not always effective, and relapses are frequent after cessation. Eighteen subjects were entered into this randomized-entry controlled trial designed to determine if intravenous immunoglobulin or plasma exchange would be superior to prednisone in decreasing the severity of chorea. Mean chorea severity for the entire group was significantly lower at the 1-month follow-up evaluation (overall 48% improvement). Although the between-group differences were not statistically significant, clinical improvements appeared to be more rapid and robust in the intravenous immunoglobulin and plasma exchange groups than in the prednisone group (mean chorea severity scores decreased by 72% in the intravenous immunoglobulin group, 50% in the plasma exchange group, and 29% in the prednisone group). Larger studies are required to confirm these clinical observations and to determine if these treatments are cost-effective for this disorder. SN - 0883-0738 UR - https://www.unboundmedicine.com/medline/citation/15968928/Treatment_of_Sydenham L2 - https://journals.sagepub.com/doi/10.1177/08830738050200050601?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -