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Influence of the metal film thickness on the sensitivity of surface plasmon resonance biosensors.
Appl Spectrosc. 2005 May; 59(5):661-7.AS

Abstract

The influence of the metal film thickness (i.e., the chromium adhesion promoting film and the gold film) on the sensitivity of surface plasmon resonance (SPR) signals (i.e., resonance angle shift and reflectance change) towards the thickness variation of the nonabsorbing dielectric film is investigated. The sensitivity of reflectance change decreases when a thick chromium film or a thin gold film is employed. Its linear range becomes narrower as the thickness of the metal films increases. The sensitivity and linear range of the resonance angle shift are not affected by the thickness variation of the metal films. The phenomena were theoretically explained based on the attenuated total reflection (ATR) generated evanescent field at the prism/metal interface and the SPR-generated evanescent field at the metal/dielectric interface.

Authors+Show Affiliations

Ekgasit S
Sensor Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand. sanong.e@chula.ac.th
Thammacharoen C
No affiliation info available
Yu F
No affiliation info available
Knoll W
No affiliation info available

MeSH

Biosensing TechniquesChromiumEquipment DesignEquipment Failure AnalysisGoldMaterials TestingMembranes, ArtificialMetalsMolecular ConformationReproducibility of ResultsSensitivity and SpecificitySurface Plasmon Resonance

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

15969812

Citation

Ekgasit, Sanong, et al. "Influence of the Metal Film Thickness On the Sensitivity of Surface Plasmon Resonance Biosensors." Applied Spectroscopy, vol. 59, no. 5, 2005, pp. 661-7.
Ekgasit S, Thammacharoen C, Yu F, et al. Influence of the metal film thickness on the sensitivity of surface plasmon resonance biosensors. Appl Spectrosc. 2005;59(5):661-7.
Ekgasit, S., Thammacharoen, C., Yu, F., & Knoll, W. (2005). Influence of the metal film thickness on the sensitivity of surface plasmon resonance biosensors. Applied Spectroscopy, 59(5), 661-7.
Ekgasit S, et al. Influence of the Metal Film Thickness On the Sensitivity of Surface Plasmon Resonance Biosensors. Appl Spectrosc. 2005;59(5):661-7. PubMed PMID: 15969812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of the metal film thickness on the sensitivity of surface plasmon resonance biosensors. AU - Ekgasit,Sanong, AU - Thammacharoen,Chuchaat, AU - Yu,Fang, AU - Knoll,Wolfgang, PY - 2005/6/23/pubmed PY - 2005/9/9/medline PY - 2005/6/23/entrez SP - 661 EP - 7 JF - Applied spectroscopy JO - Appl Spectrosc VL - 59 IS - 5 N2 - The influence of the metal film thickness (i.e., the chromium adhesion promoting film and the gold film) on the sensitivity of surface plasmon resonance (SPR) signals (i.e., resonance angle shift and reflectance change) towards the thickness variation of the nonabsorbing dielectric film is investigated. The sensitivity of reflectance change decreases when a thick chromium film or a thin gold film is employed. Its linear range becomes narrower as the thickness of the metal films increases. The sensitivity and linear range of the resonance angle shift are not affected by the thickness variation of the metal films. The phenomena were theoretically explained based on the attenuated total reflection (ATR) generated evanescent field at the prism/metal interface and the SPR-generated evanescent field at the metal/dielectric interface. SN - 0003-7028 UR - https://www.unboundmedicine.com/medline/citation/15969812/Influence_of_the_metal_film_thickness_on_the_sensitivity_of_surface_plasmon_resonance_biosensors_ DB - PRIME DP - Unbound Medicine ER -