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[Prospective clinical study on serum immunity in IgG-antibodies positive patients convalescent from severe acute respiratory syndrome].
Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005 Jun; 17(6):335-7.ZW

Abstract

OBJECTIVE

To investigate the serum immunological characteristics in patients convalescent from severe acute respiratory syndrome (SARS).

METHODS

In the 1 st, 3 rd, 6 th month after their discharge, eg. SARS-IgG, T cell subsets, blood routine, and the blood biochemistry were systemically determined in SARS convalescent patients.

RESULTS

The SARS-antibodies could be used as the diagnostic evidence. During the 6 months after discharge, the titers of SARS-antibodies were high, but they lowered along with passage of time. At the first recheck, the CD4(+) lymphocyte count was lower than normal level in 55.9% of patients, the CD3(+) lymphocyte count was lower than normal level in 31.2% of patients, and the CD8(+) lymphocyte count was lower than normal level in 14.0% of patients. At the second recheck, the levels of T cell subsets recovered to normal level in the most patients.

CONCLUSION

T cell subsets, and the number of leukocyte are abnormal in some patients convalescent from SARS. All the indexes examined recover to normal levels half year after discharge. Therefore, it is necessary to follow up the changes in the levels of SARS-antibodies.

Authors+Show Affiliations

Beijing Friendship Hospital Affiliated to Capital University of Medical Sciences, Beijing 100050, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

15970096

Citation

Yin, Cheng-hong, et al. "[Prospective Clinical Study On Serum Immunity in IgG-antibodies Positive Patients Convalescent From Severe Acute Respiratory Syndrome]." Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, vol. 17, no. 6, 2005, pp. 335-7.
Yin CH, Wang C, Wen Y, et al. [Prospective clinical study on serum immunity in IgG-antibodies positive patients convalescent from severe acute respiratory syndrome]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005;17(6):335-7.
Yin, C. H., Wang, C., Wen, Y., Jiang, L., Liu, Y., Chen, J. H., Tang, S. Z., Yue, M. X., He, Z. Y., Zhang, S. W., & Wang, B. E. (2005). [Prospective clinical study on serum immunity in IgG-antibodies positive patients convalescent from severe acute respiratory syndrome]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue = Chinese Critical Care Medicine = Zhongguo Weizhongbing Jijiuyixue, 17(6), 335-7.
Yin CH, et al. [Prospective Clinical Study On Serum Immunity in IgG-antibodies Positive Patients Convalescent From Severe Acute Respiratory Syndrome]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2005;17(6):335-7. PubMed PMID: 15970096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Prospective clinical study on serum immunity in IgG-antibodies positive patients convalescent from severe acute respiratory syndrome]. AU - Yin,Cheng-hong, AU - Wang,Chao, AU - Wen,Yan, AU - Jiang,Li, AU - Liu,Ying, AU - Chen,Jiang-hong, AU - Tang,Shu-zhen, AU - Yue,Mao-xing, AU - He,Zheng-yi, AU - Zhang,Shu-wen, AU - Wang,Bao-en, PY - 2005/6/23/pubmed PY - 2009/12/16/medline PY - 2005/6/23/entrez SP - 335 EP - 7 JF - Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue JO - Zhongguo Wei Zhong Bing Ji Jiu Yi Xue VL - 17 IS - 6 N2 - OBJECTIVE: To investigate the serum immunological characteristics in patients convalescent from severe acute respiratory syndrome (SARS). METHODS: In the 1 st, 3 rd, 6 th month after their discharge, eg. SARS-IgG, T cell subsets, blood routine, and the blood biochemistry were systemically determined in SARS convalescent patients. RESULTS: The SARS-antibodies could be used as the diagnostic evidence. During the 6 months after discharge, the titers of SARS-antibodies were high, but they lowered along with passage of time. At the first recheck, the CD4(+) lymphocyte count was lower than normal level in 55.9% of patients, the CD3(+) lymphocyte count was lower than normal level in 31.2% of patients, and the CD8(+) lymphocyte count was lower than normal level in 14.0% of patients. At the second recheck, the levels of T cell subsets recovered to normal level in the most patients. CONCLUSION: T cell subsets, and the number of leukocyte are abnormal in some patients convalescent from SARS. All the indexes examined recover to normal levels half year after discharge. Therefore, it is necessary to follow up the changes in the levels of SARS-antibodies. SN - 1003-0603 UR - https://www.unboundmedicine.com/medline/citation/15970096/[Prospective_clinical_study_on_serum_immunity_in_IgG_antibodies_positive_patients_convalescent_from_severe_acute_respiratory_syndrome]_ L2 - https://antibodies.cancer.gov/detail/CPTC-CD4-1 DB - PRIME DP - Unbound Medicine ER -