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Inhibitory effects of long-term administration of ferulic acid on astrocyte activation induced by intracerebroventricular injection of beta-amyloid peptide (1-42) in mice.

Abstract

Accumulating evidence indicates that glial cells are actively involved in the pathogenesis of Alzheimer's disease. We recently reported protective effects of long-term administration of ferulic acid against learning and memory deficit induced by centrally administered beta-amyloid peptide (Abeta)1-42 in mice. In that report, we found that the Abeta1-42-induced increases in immunoreactivities of glial fibrillary acidic protein, the astrocyte marker, and interleukin(IL)-1beta in the hippocampus are also suppressed by pretreatment with ferulic acid. In the present study, we aimed to further characterize the effect of long-term administration of ferulic acid on the centrally administered Abeta1-42-induced activation of glial cells in mice. Mice were allowed free access to drinking water (control) or water containing ferulic acid (0.006%) for 4 weeks, and then Abeta1-42 (410 pmol) was administered via intracerebroventricular injection. Intracerebroventricularly injected Abeta1-42 induced an increase in immunoreactivities of endothelial nitric oxide synthase (eNOS) and 3-nitrotyrosine (3-NT) in the activated astrocytes in the hippocampus. Pretreatment of ferulic acid for 4 weeks prevented the Abeta1-42-induced increase in eNOS and 3-NT immunoreactivities. Administration of ferulic acid per se induced a transient and slight increase in eNOS immunoreactivity in the hippocampus on day 14, which returned to basal levels on day 28. Intracerebroventricularly injected Abeta1-42 also increased interleukin-1alpha(IL-1alpha) immunoreactivity in the hippocampus, which was also suppressed by pretreatment with ferulic acid. These results demonstrate that long-term administration of ferulic acid induces suppression of the centrallly injected Abeta1-42-induced activation of astrocytes which is suggested to underlie the protective effect of ferulic acid against Abeta1-42 toxicity in vivo.

Authors+Show Affiliations

Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University, Chunchon, 200-702, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15970368

Citation

Cho, Jae-Young, et al. "Inhibitory Effects of Long-term Administration of Ferulic Acid On Astrocyte Activation Induced By Intracerebroventricular Injection of Beta-amyloid Peptide (1-42) in Mice." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 29, no. 6, 2005, pp. 901-7.
Cho JY, Kim HS, Kim DH, et al. Inhibitory effects of long-term administration of ferulic acid on astrocyte activation induced by intracerebroventricular injection of beta-amyloid peptide (1-42) in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(6):901-7.
Cho, J. Y., Kim, H. S., Kim, D. H., Yan, J. J., Suh, H. W., & Song, D. K. (2005). Inhibitory effects of long-term administration of ferulic acid on astrocyte activation induced by intracerebroventricular injection of beta-amyloid peptide (1-42) in mice. Progress in Neuro-psychopharmacology & Biological Psychiatry, 29(6), pp. 901-7.
Cho JY, et al. Inhibitory Effects of Long-term Administration of Ferulic Acid On Astrocyte Activation Induced By Intracerebroventricular Injection of Beta-amyloid Peptide (1-42) in Mice. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(6):901-7. PubMed PMID: 15970368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inhibitory effects of long-term administration of ferulic acid on astrocyte activation induced by intracerebroventricular injection of beta-amyloid peptide (1-42) in mice. AU - Cho,Jae-Young, AU - Kim,Hee-Sung, AU - Kim,Do-Hoon, AU - Yan,Ji-Jing, AU - Suh,Hong-Won, AU - Song,Dong-Keun, PY - 2005/04/06/accepted PY - 2005/6/23/pubmed PY - 2005/10/28/medline PY - 2005/6/23/entrez SP - 901 EP - 7 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 29 IS - 6 N2 - Accumulating evidence indicates that glial cells are actively involved in the pathogenesis of Alzheimer's disease. We recently reported protective effects of long-term administration of ferulic acid against learning and memory deficit induced by centrally administered beta-amyloid peptide (Abeta)1-42 in mice. In that report, we found that the Abeta1-42-induced increases in immunoreactivities of glial fibrillary acidic protein, the astrocyte marker, and interleukin(IL)-1beta in the hippocampus are also suppressed by pretreatment with ferulic acid. In the present study, we aimed to further characterize the effect of long-term administration of ferulic acid on the centrally administered Abeta1-42-induced activation of glial cells in mice. Mice were allowed free access to drinking water (control) or water containing ferulic acid (0.006%) for 4 weeks, and then Abeta1-42 (410 pmol) was administered via intracerebroventricular injection. Intracerebroventricularly injected Abeta1-42 induced an increase in immunoreactivities of endothelial nitric oxide synthase (eNOS) and 3-nitrotyrosine (3-NT) in the activated astrocytes in the hippocampus. Pretreatment of ferulic acid for 4 weeks prevented the Abeta1-42-induced increase in eNOS and 3-NT immunoreactivities. Administration of ferulic acid per se induced a transient and slight increase in eNOS immunoreactivity in the hippocampus on day 14, which returned to basal levels on day 28. Intracerebroventricularly injected Abeta1-42 also increased interleukin-1alpha(IL-1alpha) immunoreactivity in the hippocampus, which was also suppressed by pretreatment with ferulic acid. These results demonstrate that long-term administration of ferulic acid induces suppression of the centrallly injected Abeta1-42-induced activation of astrocytes which is suggested to underlie the protective effect of ferulic acid against Abeta1-42 toxicity in vivo. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/15970368/Inhibitory_effects_of_long_term_administration_of_ferulic_acid_on_astrocyte_activation_induced_by_intracerebroventricular_injection_of_beta_amyloid_peptide__1_42__in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(05)00141-7 DB - PRIME DP - Unbound Medicine ER -