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Outcomes of pregnancies achieved by donor egg in vitro fertilization--a comparison with standard in vitro fertilization pregnancies.
Am J Obstet Gynecol. 2005 Jun; 192(6):2002-6; discussion 2006-8.AJ

Abstract

OBJECTIVE

Prior studies on donor egg in vitro fertilization (DE-IVF) outcomes have been limited by the lack of an appropriate control group. Here, we review the obstetric and perinatal outcomes of pregnancies achieved by DE-IVF and compare these pregnancies with those of women who also needed similar assisted reproductive techniques, of similar socioeconomic status, and cared for by a small group of 8 physicians applying consistent diagnostic and treatment approaches.

STUDY DESIGN

A retrospective review of 50 consecutive pregnancies achieved by DE- IVF and 50 consecutive pregnancies achieved by standard IVF (STD-IVF) was performed. Comparisons were made for demographic and medical confounding factors and for outcome measures.

RESULTS

The 2 groups were nearly identical for gravidity, parity, and multiple gestations but did vary in maternal age. Average age of patients receiving DE-IVF was 41.9(+/-5.1), whereas the STD-IVF averaged 37.7(+/-3.6) years (P < .001). Key obstetric outcomes did not differ between the 2 groups with the exception of pregnancy-induced hypertension. In patients with DE-IVF, 26% had pregnancy-induced hypertension (PIH) develop, whereas this occurred in only 8% of the STD-IVF group (P = .02). Examining nulliparous patients only, 37.1% of DE-IVF had PIH develop, whereas only 8% of STD-IVF group achieved that diagnosis (P < .003). An analysis with a multiple logistic regression in nulliparous patients found odds ratios of 7.1 (95% CI, 1.4-36.7) in DE versus STD-IVF, odds ratio 4.9 (95% CI, 1.3-18.3) for multiple gestation versus singleton, and odds ratio 1.0 (95% CI, 0.9-1.1) for maternal age.

CONCLUSION

Nulliparous pregnancies achieved by DE-IVF are associated with an increased risk of PIH; however, excellent outcomes can still be expected.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, California Pacific Medical Center, San Francisco, USA.No affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article
Multicenter Study

Language

eng

PubMed ID

15970875

Citation

Wiggins, Donna A., and Elliott Main. "Outcomes of Pregnancies Achieved By Donor Egg in Vitro Fertilization--a Comparison With Standard in Vitro Fertilization Pregnancies." American Journal of Obstetrics and Gynecology, vol. 192, no. 6, 2005, pp. 2002-6; discussion 2006-8.
Wiggins DA, Main E. Outcomes of pregnancies achieved by donor egg in vitro fertilization--a comparison with standard in vitro fertilization pregnancies. Am J Obstet Gynecol. 2005;192(6):2002-6; discussion 2006-8.
Wiggins, D. A., & Main, E. (2005). Outcomes of pregnancies achieved by donor egg in vitro fertilization--a comparison with standard in vitro fertilization pregnancies. American Journal of Obstetrics and Gynecology, 192(6), 2002-6; discussion 2006-8.
Wiggins DA, Main E. Outcomes of Pregnancies Achieved By Donor Egg in Vitro Fertilization--a Comparison With Standard in Vitro Fertilization Pregnancies. Am J Obstet Gynecol. 2005;192(6):2002-6; discussion 2006-8. PubMed PMID: 15970875.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcomes of pregnancies achieved by donor egg in vitro fertilization--a comparison with standard in vitro fertilization pregnancies. AU - Wiggins,Donna A, AU - Main,Elliott, PY - 2005/6/23/pubmed PY - 2005/7/26/medline PY - 2005/6/23/entrez SP - 2002-6; discussion 2006-8 JF - American journal of obstetrics and gynecology JO - Am. J. Obstet. Gynecol. VL - 192 IS - 6 N2 - OBJECTIVE: Prior studies on donor egg in vitro fertilization (DE-IVF) outcomes have been limited by the lack of an appropriate control group. Here, we review the obstetric and perinatal outcomes of pregnancies achieved by DE-IVF and compare these pregnancies with those of women who also needed similar assisted reproductive techniques, of similar socioeconomic status, and cared for by a small group of 8 physicians applying consistent diagnostic and treatment approaches. STUDY DESIGN: A retrospective review of 50 consecutive pregnancies achieved by DE- IVF and 50 consecutive pregnancies achieved by standard IVF (STD-IVF) was performed. Comparisons were made for demographic and medical confounding factors and for outcome measures. RESULTS: The 2 groups were nearly identical for gravidity, parity, and multiple gestations but did vary in maternal age. Average age of patients receiving DE-IVF was 41.9(+/-5.1), whereas the STD-IVF averaged 37.7(+/-3.6) years (P < .001). Key obstetric outcomes did not differ between the 2 groups with the exception of pregnancy-induced hypertension. In patients with DE-IVF, 26% had pregnancy-induced hypertension (PIH) develop, whereas this occurred in only 8% of the STD-IVF group (P = .02). Examining nulliparous patients only, 37.1% of DE-IVF had PIH develop, whereas only 8% of STD-IVF group achieved that diagnosis (P < .003). An analysis with a multiple logistic regression in nulliparous patients found odds ratios of 7.1 (95% CI, 1.4-36.7) in DE versus STD-IVF, odds ratio 4.9 (95% CI, 1.3-18.3) for multiple gestation versus singleton, and odds ratio 1.0 (95% CI, 0.9-1.1) for maternal age. CONCLUSION: Nulliparous pregnancies achieved by DE-IVF are associated with an increased risk of PIH; however, excellent outcomes can still be expected. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/15970875/Outcomes_of_pregnancies_achieved_by_donor_egg_in_vitro_fertilization__a_comparison_with_standard_in_vitro_fertilization_pregnancies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002937805002759 DB - PRIME DP - Unbound Medicine ER -