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Adiponectin is associated with bone mineral density in perimenopausal women.
Horm Metab Res. 2005 May; 37(5):297-302.HM

Abstract

The aim of the current investigation was to investigate any potential effect of fasting plasma adiponectin concentration on bone tissue, and to find possible relationships of fasting plasma adiponectin level with different body composition, insulin sensitivity and physical performance parameters in a group of healthy perimenopausal women. Twenty-one premenopausal and 17 early postmenopausal women participated in this study. The women were matched for body mass index (BMI) and level of mean daily energy expenditure. Women had similar adiponectin (8.4 +/- 3.9 vs. 9.9 +/- 5.4 microg/ml) and leptin values (12.0 +/- 7.7 vs. 14.0 +/- 8.2 ng/ml) before and after menopause. Significant relationships were observed between plasma adiponectin and bone mineral content, total bone mineral density (BMD) and lumbar spine BMD values (r > - 0.36; p < 0.05). Furthermore, adiponectin had a significant negative association with total BMD (beta = - 1.228; p = 0.004) and lumbar spine BMD (beta = - 0.312; p = 0.005) independent of the influence that other measured body compositional, hormonal or physical performance factors may exert on BMD. Adiponectin was also significantly related to waist-to-hip ratio (WHR) (beta = - 2.300; p = 0.002) and fasting insulin resistance index (FIRI) (beta = - 0.006; p = 0.007) in separate regression models. No relationship was observed between leptin and measured bone, physical performance and insulin resistance values. Leptin significantly correlated to BMI (beta = 0.018; p = 0.034), lean body mass (beta = 0.025; p = 0.024) and fat mass (beta = 0.019; p = 0.001) in separate regression models. In conclusion, the results of present study show that circulating adiponectin appears to exert an independent effect on BMD in perimenopausal women and may represent a link between adipose tissue and bone mineral density.

Authors+Show Affiliations

Institute of Sport Pedagogy and Coaching Sciences, University of Tartu, Tartu, Estonia. jaakj@ut.eeNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15971153

Citation

Jürimäe, J, et al. "Adiponectin Is Associated With Bone Mineral Density in Perimenopausal Women." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 37, no. 5, 2005, pp. 297-302.
Jürimäe J, Rembel K, Jürimäe T, et al. Adiponectin is associated with bone mineral density in perimenopausal women. Horm Metab Res. 2005;37(5):297-302.
Jürimäe, J., Rembel, K., Jürimäe, T., & Rehand, M. (2005). Adiponectin is associated with bone mineral density in perimenopausal women. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 37(5), 297-302.
Jürimäe J, et al. Adiponectin Is Associated With Bone Mineral Density in Perimenopausal Women. Horm Metab Res. 2005;37(5):297-302. PubMed PMID: 15971153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adiponectin is associated with bone mineral density in perimenopausal women. AU - Jürimäe,J, AU - Rembel,K, AU - Jürimäe,T, AU - Rehand,M, PY - 2005/6/23/pubmed PY - 2005/9/2/medline PY - 2005/6/23/entrez SP - 297 EP - 302 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm. Metab. Res. VL - 37 IS - 5 N2 - The aim of the current investigation was to investigate any potential effect of fasting plasma adiponectin concentration on bone tissue, and to find possible relationships of fasting plasma adiponectin level with different body composition, insulin sensitivity and physical performance parameters in a group of healthy perimenopausal women. Twenty-one premenopausal and 17 early postmenopausal women participated in this study. The women were matched for body mass index (BMI) and level of mean daily energy expenditure. Women had similar adiponectin (8.4 +/- 3.9 vs. 9.9 +/- 5.4 microg/ml) and leptin values (12.0 +/- 7.7 vs. 14.0 +/- 8.2 ng/ml) before and after menopause. Significant relationships were observed between plasma adiponectin and bone mineral content, total bone mineral density (BMD) and lumbar spine BMD values (r > - 0.36; p < 0.05). Furthermore, adiponectin had a significant negative association with total BMD (beta = - 1.228; p = 0.004) and lumbar spine BMD (beta = - 0.312; p = 0.005) independent of the influence that other measured body compositional, hormonal or physical performance factors may exert on BMD. Adiponectin was also significantly related to waist-to-hip ratio (WHR) (beta = - 2.300; p = 0.002) and fasting insulin resistance index (FIRI) (beta = - 0.006; p = 0.007) in separate regression models. No relationship was observed between leptin and measured bone, physical performance and insulin resistance values. Leptin significantly correlated to BMI (beta = 0.018; p = 0.034), lean body mass (beta = 0.025; p = 0.024) and fat mass (beta = 0.019; p = 0.001) in separate regression models. In conclusion, the results of present study show that circulating adiponectin appears to exert an independent effect on BMD in perimenopausal women and may represent a link between adipose tissue and bone mineral density. SN - 0018-5043 UR - https://www.unboundmedicine.com/medline/citation/15971153/Adiponectin_is_associated_with_bone_mineral_density_in_perimenopausal_women_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2005-861483 DB - PRIME DP - Unbound Medicine ER -