Tags

Type your tag names separated by a space and hit enter

Reciprocal changes in endogenous ghrelin and growth hormone during fasting in healthy women.
Am J Physiol Endocrinol Metab. 2005 Nov; 289(5):E814-22.AJ

Abstract

Ghrelin stimulates growth hormone (GH) secretion, but it is unknown whether there is a feedback of GH on ghrelin secretion. In this study, we characterized the relatedness of GH and ghrelin in a model of acute caloric deprivation in 10 healthy women (age 26.7 +/- 1.6 yr) during a 4-day fast in the early follicular phase. GH, ghrelin, and cortisol were assessed every hour over 24 h during an isocaloric diet and after a 4-day complete fast. Sampling during a normal diet at baseline demonstrated that ghrelin decreased 17.9% within 1 h after meals (P < 0.0001), but there was no meal effect on GH. BMI (22.3 +/- 0.4 vs. 21.5 +/- 0.4 kg/m2, P < 0.0001) and IGF-I (312 +/- 28 vs.124 +/- 22 ng/ml, P < 0.0001) decreased during fasting. Mean 24-h GH increased (2.6 +/- 0.5 vs. 5.6 +/- 0.5 ng/ml, P < 0.001), but ghrelin decreased (441.3 +/- 59.7 vs. 359.8 +/- 54.2 pg/ml, P = 0.012). The peak ghrelin level decreased from 483.5 to 375.6 pg/ml (P < 0.0001), and the time of the peak ghrelin changed from 0415 to 1715. In contrast, the diurnal pattern of GH was maintained, with increases in the nadir (1.1 to 3.4 ng/ml) and peak GH concentrations (4.1 to 7.9 ng/ml) from the fed to fasted state (P < 0.0001). The change in morning GH concentrations was inversely related to the change in ghrelin (r = -0.79, P = 0.012). During complete short-term caloric deprivation in healthy women, ghrelin decreases, even as GH rises, and these processes appear to be reciprocal, suggesting that GH exhibits feedback inhibition on ghrelin. Our data provide new evidence of the physiological relationship of GH and ghrelin in response to changes in protein-energy metabolism.

Authors+Show Affiliations

Program in Nutritional Metabolism, Mass. General Hospital, Harvard Medical School, Boston, MA 02114, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15972272

Citation

Koutkia, Polyxeni, et al. "Reciprocal Changes in Endogenous Ghrelin and Growth Hormone During Fasting in Healthy Women." American Journal of Physiology. Endocrinology and Metabolism, vol. 289, no. 5, 2005, pp. E814-22.
Koutkia P, Schurgin S, Berry J, et al. Reciprocal changes in endogenous ghrelin and growth hormone during fasting in healthy women. Am J Physiol Endocrinol Metab. 2005;289(5):E814-22.
Koutkia, P., Schurgin, S., Berry, J., Breu, J., Lee, B. S., Klibanski, A., & Grinspoon, S. (2005). Reciprocal changes in endogenous ghrelin and growth hormone during fasting in healthy women. American Journal of Physiology. Endocrinology and Metabolism, 289(5), E814-22.
Koutkia P, et al. Reciprocal Changes in Endogenous Ghrelin and Growth Hormone During Fasting in Healthy Women. Am J Physiol Endocrinol Metab. 2005;289(5):E814-22. PubMed PMID: 15972272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reciprocal changes in endogenous ghrelin and growth hormone during fasting in healthy women. AU - Koutkia,Polyxeni, AU - Schurgin,Sunita, AU - Berry,Jacqueline, AU - Breu,Jeff, AU - Lee,B S Hang, AU - Klibanski,Anne, AU - Grinspoon,Steven, Y1 - 2005/06/21/ PY - 2005/6/24/pubmed PY - 2005/12/13/medline PY - 2005/6/24/entrez SP - E814 EP - 22 JF - American journal of physiology. Endocrinology and metabolism JO - Am J Physiol Endocrinol Metab VL - 289 IS - 5 N2 - Ghrelin stimulates growth hormone (GH) secretion, but it is unknown whether there is a feedback of GH on ghrelin secretion. In this study, we characterized the relatedness of GH and ghrelin in a model of acute caloric deprivation in 10 healthy women (age 26.7 +/- 1.6 yr) during a 4-day fast in the early follicular phase. GH, ghrelin, and cortisol were assessed every hour over 24 h during an isocaloric diet and after a 4-day complete fast. Sampling during a normal diet at baseline demonstrated that ghrelin decreased 17.9% within 1 h after meals (P < 0.0001), but there was no meal effect on GH. BMI (22.3 +/- 0.4 vs. 21.5 +/- 0.4 kg/m2, P < 0.0001) and IGF-I (312 +/- 28 vs.124 +/- 22 ng/ml, P < 0.0001) decreased during fasting. Mean 24-h GH increased (2.6 +/- 0.5 vs. 5.6 +/- 0.5 ng/ml, P < 0.001), but ghrelin decreased (441.3 +/- 59.7 vs. 359.8 +/- 54.2 pg/ml, P = 0.012). The peak ghrelin level decreased from 483.5 to 375.6 pg/ml (P < 0.0001), and the time of the peak ghrelin changed from 0415 to 1715. In contrast, the diurnal pattern of GH was maintained, with increases in the nadir (1.1 to 3.4 ng/ml) and peak GH concentrations (4.1 to 7.9 ng/ml) from the fed to fasted state (P < 0.0001). The change in morning GH concentrations was inversely related to the change in ghrelin (r = -0.79, P = 0.012). During complete short-term caloric deprivation in healthy women, ghrelin decreases, even as GH rises, and these processes appear to be reciprocal, suggesting that GH exhibits feedback inhibition on ghrelin. Our data provide new evidence of the physiological relationship of GH and ghrelin in response to changes in protein-energy metabolism. SN - 0193-1849 UR - https://www.unboundmedicine.com/medline/citation/15972272/Reciprocal_changes_in_endogenous_ghrelin_and_growth_hormone_during_fasting_in_healthy_women_ L2 - https://journals.physiology.org/doi/10.1152/ajpendo.00093.2005?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -