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Diffusion-weighted echo-planar MRI: a valuable tool for differentiating primary parotid gland tumors?
Rofo. 2005 Jul; 177(7):940-5.ROFO

Abstract

PURPOSE

To investigate the feasibility of using diffusion-weighted (DW) echo-planar imaging (EPI) for differentiating primary parotid gland tumors.

MATERIAL AND METHODS

Fifty consecutive patients with a suspected primary tumor of the parotid gland were examined with a DW EPI sequence (TR 1,500 msec, TE 77 msec, field of view 250 x 250 mm, pixel size 2.10 x 1.95 mm, section thickness 5 mm). The b factors used were 0, 500, and 1,000 sec/mm (2). Apparent diffusion coefficient (ADC) maps were digitally transferred to MRIcro (Chris Rorden, University of Nottingham, Great Britain) and evaluated with a manually placed irregular region of interest (ROI) containing the entire tumor. Additionally, the contralateral, non affected parotid gland was measured and a circular ROI containing 100 - 200 pixels was placed in the cerebrospinal fluid (CSF) next to the spinal cord in every patient. For comparison of the results, the two-tailed Student's t test was used, based on the median ADC values for each patient, and a p-value <.05 was determined to indicate statistical significance.

RESULTS

In 45 patients, a primary neoplasm of the parotid gland could be histologically verified. For the non-affected parotid glands of all 45 evaluated patients, the mean ADC value was 1.14 x 10 (- 3) mm (2)/sec +/- 0.12 x 10 (- 3) mm (2)/sec (mean +/- standard deviation). Seven different entities of parotid gland tumors were histologically discriminated. Pleomorphic adenomas (2.14 x 10 (- 3) mm (2)/sec +/- 0.11 x 10 (- 3) mm (2)/sec), Warthin tumors (0.85 x 10 (- 3) mm (2)/sec +/- 0.1 x 10 (- 3) mm (2)/sec), and mucoepidermoid carcinomas (1.04 x 10 (- 3) mm (2)/sec +/- 0.3 x 10 (- 3) mm (2)/sec) showed statistically significant different ADC values in comparison to all other evaluated tumors (p .001), and also among each other (p <.001). Additionally, ADC values presented by lipomas were statistically significant compared to all other entities (p <.001 to .015). Among all other [corrected] primary malignant parotid gland tumors, no statistically significant ADC values could be observed (p .18 to 1).

CONCLUSION

Diffusion-weighted echo-planar MRI seems to be a valuable tool for differentiating benign from malignant primary parotid gland tumors.

Authors+Show Affiliations

Department of Diagnostic and Interventional Radiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany. c.habermann@uke.uni-hamburg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15973595

Citation

Habermann, C R., et al. "Diffusion-weighted Echo-planar MRI: a Valuable Tool for Differentiating Primary Parotid Gland Tumors?" RoFo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin, vol. 177, no. 7, 2005, pp. 940-5.
Habermann CR, Gossrau P, Graessner J, et al. Diffusion-weighted echo-planar MRI: a valuable tool for differentiating primary parotid gland tumors? Rofo. 2005;177(7):940-5.
Habermann, C. R., Gossrau, P., Graessner, J., Arndt, C., Cramer, M. C., Reitmeier, F., Jaehne, M., & Adam, G. (2005). Diffusion-weighted echo-planar MRI: a valuable tool for differentiating primary parotid gland tumors? RoFo : Fortschritte Auf Dem Gebiete Der Rontgenstrahlen Und Der Nuklearmedizin, 177(7), 940-5.
Habermann CR, et al. Diffusion-weighted Echo-planar MRI: a Valuable Tool for Differentiating Primary Parotid Gland Tumors. Rofo. 2005;177(7):940-5. PubMed PMID: 15973595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diffusion-weighted echo-planar MRI: a valuable tool for differentiating primary parotid gland tumors? AU - Habermann,C R, AU - Gossrau,P, AU - Graessner,J, AU - Arndt,C, AU - Cramer,M C, AU - Reitmeier,F, AU - Jaehne,M, AU - Adam,G, PY - 2005/6/24/pubmed PY - 2005/8/12/medline PY - 2005/6/24/entrez SP - 940 EP - 5 JF - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin JO - Rofo VL - 177 IS - 7 N2 - PURPOSE: To investigate the feasibility of using diffusion-weighted (DW) echo-planar imaging (EPI) for differentiating primary parotid gland tumors. MATERIAL AND METHODS: Fifty consecutive patients with a suspected primary tumor of the parotid gland were examined with a DW EPI sequence (TR 1,500 msec, TE 77 msec, field of view 250 x 250 mm, pixel size 2.10 x 1.95 mm, section thickness 5 mm). The b factors used were 0, 500, and 1,000 sec/mm (2). Apparent diffusion coefficient (ADC) maps were digitally transferred to MRIcro (Chris Rorden, University of Nottingham, Great Britain) and evaluated with a manually placed irregular region of interest (ROI) containing the entire tumor. Additionally, the contralateral, non affected parotid gland was measured and a circular ROI containing 100 - 200 pixels was placed in the cerebrospinal fluid (CSF) next to the spinal cord in every patient. For comparison of the results, the two-tailed Student's t test was used, based on the median ADC values for each patient, and a p-value <.05 was determined to indicate statistical significance. RESULTS: In 45 patients, a primary neoplasm of the parotid gland could be histologically verified. For the non-affected parotid glands of all 45 evaluated patients, the mean ADC value was 1.14 x 10 (- 3) mm (2)/sec +/- 0.12 x 10 (- 3) mm (2)/sec (mean +/- standard deviation). Seven different entities of parotid gland tumors were histologically discriminated. Pleomorphic adenomas (2.14 x 10 (- 3) mm (2)/sec +/- 0.11 x 10 (- 3) mm (2)/sec), Warthin tumors (0.85 x 10 (- 3) mm (2)/sec +/- 0.1 x 10 (- 3) mm (2)/sec), and mucoepidermoid carcinomas (1.04 x 10 (- 3) mm (2)/sec +/- 0.3 x 10 (- 3) mm (2)/sec) showed statistically significant different ADC values in comparison to all other evaluated tumors (p .001), and also among each other (p <.001). Additionally, ADC values presented by lipomas were statistically significant compared to all other entities (p <.001 to .015). Among all other [corrected] primary malignant parotid gland tumors, no statistically significant ADC values could be observed (p .18 to 1). CONCLUSION: Diffusion-weighted echo-planar MRI seems to be a valuable tool for differentiating benign from malignant primary parotid gland tumors. SN - 1438-9029 UR - https://www.unboundmedicine.com/medline/citation/15973595/Diffusion_weighted_echo_planar_MRI:_a_valuable_tool_for_differentiating_primary_parotid_gland_tumors L2 - https://www.thieme-connect.com/DOI/DOI?10.1055/s-2005-858297 DB - PRIME DP - Unbound Medicine ER -