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Recent advances in hepatorenal syndrome.
Trop Gastroenterol. 2005 Jan-Mar; 26(1):13-20.TG

Abstract

Hepatorenal syndrome is a common complication of advanced cirrhosis, characterized by renal failure and major disturbances in circulatory function. Renal failure is caused by intense vasoconstriction of the renal circulation. The syndrome is probably the final consequence of extreme underfilling of the arterial circulation secondary to arterial vasodilatation in the splanchninc vascular bed. The diagnosis of HRS is currently based on the exclusion of other causes of renal failure. The prognosis is very poor, particularly when there is rapidly progressive renal failure (type 1). Liver transplantation is the best option in patients without contraindications to the procedure, but it is not always possible owing to the short survival expectancy. Therapies introduced during the past few years, such a vasoconstrictor drugs (vasopressin analogues, mu-adrenergic agonist) or the transjugular intrahepatic portosystemic shunt, are effective in improving renal function. Nevertheless, liver transplantation should still be done in suitable patients even after improvement of renal function because the outcome of HRS is poor.

Authors+Show Affiliations

Arroyo V
Liver Unit, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi-Sunyer, University of Barcelona School of Medicine, Barcelona, Catalunya, Spain. arroyo@medicina.ub.es
Torre A
No affiliation info available
Guevara M
No affiliation info available

MeSH

Clinical Trials as TopicHepatorenal SyndromeHumansPrognosis

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15974232

Citation

Arroyo, Vicente, et al. "Recent Advances in Hepatorenal Syndrome." Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation, vol. 26, no. 1, 2005, pp. 13-20.
Arroyo V, Torre A, Guevara M. Recent advances in hepatorenal syndrome. Trop Gastroenterol. 2005;26(1):13-20.
Arroyo, V., Torre, A., & Guevara, M. (2005). Recent advances in hepatorenal syndrome. Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation, 26(1), 13-20.
Arroyo V, Torre A, Guevara M. Recent Advances in Hepatorenal Syndrome. Trop Gastroenterol. 2005 Jan-Mar;26(1):13-20. PubMed PMID: 15974232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recent advances in hepatorenal syndrome. AU - Arroyo,Vicente, AU - Torre,Aldo, AU - Guevara,Mónica, PY - 2005/6/25/pubmed PY - 2005/7/22/medline PY - 2005/6/25/entrez SP - 13 EP - 20 JF - Tropical gastroenterology : official journal of the Digestive Diseases Foundation JO - Trop Gastroenterol VL - 26 IS - 1 N2 - Hepatorenal syndrome is a common complication of advanced cirrhosis, characterized by renal failure and major disturbances in circulatory function. Renal failure is caused by intense vasoconstriction of the renal circulation. The syndrome is probably the final consequence of extreme underfilling of the arterial circulation secondary to arterial vasodilatation in the splanchninc vascular bed. The diagnosis of HRS is currently based on the exclusion of other causes of renal failure. The prognosis is very poor, particularly when there is rapidly progressive renal failure (type 1). Liver transplantation is the best option in patients without contraindications to the procedure, but it is not always possible owing to the short survival expectancy. Therapies introduced during the past few years, such a vasoconstrictor drugs (vasopressin analogues, mu-adrenergic agonist) or the transjugular intrahepatic portosystemic shunt, are effective in improving renal function. Nevertheless, liver transplantation should still be done in suitable patients even after improvement of renal function because the outcome of HRS is poor. SN - 0250-636X UR - https://www.unboundmedicine.com/medline/citation/15974232/Recent_advances_in_hepatorenal_syndrome_ DB - PRIME DP - Unbound Medicine ER -