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Anti-Helicobacter pylori compounds from Santalum album.
J Nat Prod. 2005 Jun; 68(6):819-24.JN

Abstract

Six new sesquiterpenes, (Z)-2beta-hydroxy-14-hydro-beta-santalol (1), (Z)-2alpha-hydroxy-albumol (2), 2R-(Z)-campherene-2,13-diol (3), (Z)-campherene-2beta,13-diol (4), (Z)-7-hydroxynuciferol (5), and (Z)-1beta-hydroxy-2-hydrolanceol (6), together with five known compounds, (Z)-alpha-santalol (7), (Z)-beta-santalol (8), (Z)-lanceol (9), alpha-santaldiol (10), and beta-santaldiol (11), were isolated from Santalum album, by using bioassay-guided fractionation for Helicobacter pylori. The structures were determined by extensive NMR studies. The absolute configuration of compound 3 was determined by a modified Mosher method. The crude extracts as well as the isolated compounds showed antibacterial activity against H. pylori. Especially, compounds 7 and 8 have strong anti-H. pylori activities against a clarithromycin-resistant strain (TS281) as well as other strains.

Authors+Show Affiliations

Ochi T
Graduate School of Pharmaceutical Sciences, University of Tokushima, Japan.
Shibata H
No affiliation info available
Higuti T
No affiliation info available
Kodama KH
No affiliation info available
Kusumi T
No affiliation info available
Takaishi Y
No affiliation info available

MeSH

Anti-Bacterial AgentsClarithromycinDrug Resistance, BacterialHelicobacter pyloriJapanMicrobial Sensitivity TestsMolecular StructureNuclear Magnetic Resonance, BiomolecularPlants, MedicinalSantalumSesquiterpenesStereoisomerism

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15974602

Citation

Ochi, Toshimasa, et al. "Anti-Helicobacter Pylori Compounds From Santalum Album." Journal of Natural Products, vol. 68, no. 6, 2005, pp. 819-24.
Ochi T, Shibata H, Higuti T, et al. Anti-Helicobacter pylori compounds from Santalum album. J Nat Prod. 2005;68(6):819-24.
Ochi, T., Shibata, H., Higuti, T., Kodama, K. H., Kusumi, T., & Takaishi, Y. (2005). Anti-Helicobacter pylori compounds from Santalum album. Journal of Natural Products, 68(6), 819-24.
Ochi T, et al. Anti-Helicobacter Pylori Compounds From Santalum Album. J Nat Prod. 2005;68(6):819-24. PubMed PMID: 15974602.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-Helicobacter pylori compounds from Santalum album. AU - Ochi,Toshimasa, AU - Shibata,Hirofumi, AU - Higuti,Tomihiko, AU - Kodama,Ko-hei, AU - Kusumi,Takenori, AU - Takaishi,Yoshihisa, PY - 2005/6/25/pubmed PY - 2005/8/12/medline PY - 2005/6/25/entrez SP - 819 EP - 24 JF - Journal of natural products JO - J Nat Prod VL - 68 IS - 6 N2 - Six new sesquiterpenes, (Z)-2beta-hydroxy-14-hydro-beta-santalol (1), (Z)-2alpha-hydroxy-albumol (2), 2R-(Z)-campherene-2,13-diol (3), (Z)-campherene-2beta,13-diol (4), (Z)-7-hydroxynuciferol (5), and (Z)-1beta-hydroxy-2-hydrolanceol (6), together with five known compounds, (Z)-alpha-santalol (7), (Z)-beta-santalol (8), (Z)-lanceol (9), alpha-santaldiol (10), and beta-santaldiol (11), were isolated from Santalum album, by using bioassay-guided fractionation for Helicobacter pylori. The structures were determined by extensive NMR studies. The absolute configuration of compound 3 was determined by a modified Mosher method. The crude extracts as well as the isolated compounds showed antibacterial activity against H. pylori. Especially, compounds 7 and 8 have strong anti-H. pylori activities against a clarithromycin-resistant strain (TS281) as well as other strains. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/15974602/Anti_Helicobacter_pylori_compounds_from_Santalum_album_ DB - PRIME DP - Unbound Medicine ER -