Tags

Type your tag names separated by a space and hit enter

Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis.
J Nat Prod. 2005 Jun; 68(6):853-7.JN

Abstract

Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line.

Authors+Show Affiliations

Appendino G
Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Italy.
Aviello G
No affiliation info available
Ballero M
No affiliation info available
Borrelli F
No affiliation info available
Fattorusso E
No affiliation info available
Petrucci F
No affiliation info available
Santelia FU
No affiliation info available
Taglialatela-Scafati O
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicAsteraceaeDrug Screening Assays, AntitumorHumansItalyMolecular StructureNuclear Magnetic Resonance, BiomolecularPlants, MedicinalSesquiterpenes, GermacraneStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15974607

Citation

Appendino, Giovanni, et al. "Cytotoxic Germacrane Sesquiterpenes From the Aerial Parts of Santolina Insularis." Journal of Natural Products, vol. 68, no. 6, 2005, pp. 853-7.
Appendino G, Aviello G, Ballero M, et al. Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis. J Nat Prod. 2005;68(6):853-7.
Appendino, G., Aviello, G., Ballero, M., Borrelli, F., Fattorusso, E., Petrucci, F., Santelia, F. U., & Taglialatela-Scafati, O. (2005). Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis. Journal of Natural Products, 68(6), 853-7.
Appendino G, et al. Cytotoxic Germacrane Sesquiterpenes From the Aerial Parts of Santolina Insularis. J Nat Prod. 2005;68(6):853-7. PubMed PMID: 15974607.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytotoxic germacrane sesquiterpenes from the aerial parts of Santolina insularis. AU - Appendino,Giovanni, AU - Aviello,Gabriella, AU - Ballero,Mauro, AU - Borrelli,Francesca, AU - Fattorusso,Ernesto, AU - Petrucci,Francesca, AU - Santelia,Federico U, AU - Taglialatela-Scafati,Orazio, PY - 2005/6/25/pubmed PY - 2005/8/12/medline PY - 2005/6/25/entrez SP - 853 EP - 7 JF - Journal of natural products JO - J Nat Prod VL - 68 IS - 6 N2 - Chemical investigation of Santolina insularis afforded 11 germacrane sesquiterpenes (1-11), four of which (2, 3, 10, and 11) are new. The stereostructures of these compounds have been established by a combination of spectroscopic techniques (mainly NMR), chemical transformations, and application of the modified Mosher method. Compounds 8 and 10 showed a potent and selective cytotoxic activity against the human colon carcinoma cell line. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/15974607/Cytotoxic_germacrane_sesquiterpenes_from_the_aerial_parts_of_Santolina_insularis_ DB - PRIME DP - Unbound Medicine ER -