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Association of C-reactive protein with body fat, diabetes and coronary artery disease in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-6).
Diabet Med. 2005 Jul; 22(7):863-70.DM

Abstract

OBJECTIVE

The aim of the study was to determine the association of high sensitivity C-reactive protein (hs-CRP) with body fat, diabetes and coronary artery disease (CAD) in an urban south Indian population.

DESIGN

The study was conducted on 150 subjects selected from the Chennai Urban Rural Epidemiology Study (CURES), an ongoing population-based study on a representative population of Chennai (formerly Madras). Group 1 comprised of non-diabetic subjects without CAD (n = 50). Type 2 diabetic subjects without CAD formed Group 2 (n = 50); Group 3 comprised of Type 2 diabetic subjects with CAD (n = 50). CAD was diagnosed based on electrocardiographic (ECG) changes suggestive of ST segment depression and/or Q wave changes using appropriate Minnesota codes. All study subjects were non-smokers, and had no infectious or inflammatory diseases. The plasma levels of hs-CRP were measured using a highly sensitive nephelometric assay. Body fat was calculated using Siri's formula using skin fold measurements.

RESULTS

Diabetic subjects with (2.89 mg/l) and without (2.25 mg/l) CAD had significantly higher hs-CRP levels compared with non-diabetic subjects without CAD (0.99 mg/l, P < 0.001). hs-CRP values increased with increases in tertiles of body fat (ANOVAP < 0.001) and HbA1c (ANOVAP < 0.001). Multiple logistic regression analysis revealed hs-CRP to be strongly associated with CAD (OR: 1.649, P = 0.040) and diabetes (OR: 2.264, P = 0.008) even after adjusting for age and gender. Regression analysis also revealed body fat to be strongly associated with diabetes and CAD even after adjusting for age and gender (P < 0.001). hs-CRP influenced this association for diabetes but not for CAD.

CONCLUSION

hs-CRP showed a strong association with CAD and diabetes, even after adjusting for age and gender. The association of body fat with diabetes seems to be mediated through hs-CRP. However, hs-CRP does not appear to mediate the relationship between body fat and CAD.

Authors+Show Affiliations

Madras Diabetes Research Foundation, Gopalapuram, Chennai, India. mvdsc@vsnl.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15975100

Citation

Mohan, V, et al. "Association of C-reactive Protein With Body Fat, Diabetes and Coronary Artery Disease in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-6)." Diabetic Medicine : a Journal of the British Diabetic Association, vol. 22, no. 7, 2005, pp. 863-70.
Mohan V, Deepa R, Velmurugan K, et al. Association of C-reactive protein with body fat, diabetes and coronary artery disease in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-6). Diabet Med. 2005;22(7):863-70.
Mohan, V., Deepa, R., Velmurugan, K., & Premalatha, G. (2005). Association of C-reactive protein with body fat, diabetes and coronary artery disease in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-6). Diabetic Medicine : a Journal of the British Diabetic Association, 22(7), 863-70.
Mohan V, et al. Association of C-reactive Protein With Body Fat, Diabetes and Coronary Artery Disease in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-6). Diabet Med. 2005;22(7):863-70. PubMed PMID: 15975100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of C-reactive protein with body fat, diabetes and coronary artery disease in Asian Indians: the Chennai Urban Rural Epidemiology Study (CURES-6). AU - Mohan,V, AU - Deepa,R, AU - Velmurugan,K, AU - Premalatha,G, PY - 2005/6/25/pubmed PY - 2005/9/24/medline PY - 2005/6/25/entrez SP - 863 EP - 70 JF - Diabetic medicine : a journal of the British Diabetic Association JO - Diabet Med VL - 22 IS - 7 N2 - OBJECTIVE: The aim of the study was to determine the association of high sensitivity C-reactive protein (hs-CRP) with body fat, diabetes and coronary artery disease (CAD) in an urban south Indian population. DESIGN: The study was conducted on 150 subjects selected from the Chennai Urban Rural Epidemiology Study (CURES), an ongoing population-based study on a representative population of Chennai (formerly Madras). Group 1 comprised of non-diabetic subjects without CAD (n = 50). Type 2 diabetic subjects without CAD formed Group 2 (n = 50); Group 3 comprised of Type 2 diabetic subjects with CAD (n = 50). CAD was diagnosed based on electrocardiographic (ECG) changes suggestive of ST segment depression and/or Q wave changes using appropriate Minnesota codes. All study subjects were non-smokers, and had no infectious or inflammatory diseases. The plasma levels of hs-CRP were measured using a highly sensitive nephelometric assay. Body fat was calculated using Siri's formula using skin fold measurements. RESULTS: Diabetic subjects with (2.89 mg/l) and without (2.25 mg/l) CAD had significantly higher hs-CRP levels compared with non-diabetic subjects without CAD (0.99 mg/l, P < 0.001). hs-CRP values increased with increases in tertiles of body fat (ANOVAP < 0.001) and HbA1c (ANOVAP < 0.001). Multiple logistic regression analysis revealed hs-CRP to be strongly associated with CAD (OR: 1.649, P = 0.040) and diabetes (OR: 2.264, P = 0.008) even after adjusting for age and gender. Regression analysis also revealed body fat to be strongly associated with diabetes and CAD even after adjusting for age and gender (P < 0.001). hs-CRP influenced this association for diabetes but not for CAD. CONCLUSION: hs-CRP showed a strong association with CAD and diabetes, even after adjusting for age and gender. The association of body fat with diabetes seems to be mediated through hs-CRP. However, hs-CRP does not appear to mediate the relationship between body fat and CAD. SN - 0742-3071 UR - https://www.unboundmedicine.com/medline/citation/15975100/Association_of_C_reactive_protein_with_body_fat_diabetes_and_coronary_artery_disease_in_Asian_Indians:_the_Chennai_Urban_Rural_Epidemiology_Study__CURES_6__ L2 - https://doi.org/10.1111/j.1464-5491.2005.01541.x DB - PRIME DP - Unbound Medicine ER -