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Plasma pyridoxal 5'-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill.
Nutrition. 2005 Jul-Aug; 21(7-8):779-85.N

Abstract

OBJECTIVES

This study assessed the effect of vitamin B6 status on immune responses in mechanically ventilated, critically ill patients and compared the results with those of healthy controls.

METHODS

This was designed as a cross-sectional observational study. Forty patients in the intensive care unit successfully completed this study. Vitamin B6 intake was recorded for 8 d. Severity of illness (Second Acute Physiology and Chronic Health Evaluation score) was recorded. Thirty-eighty healthy controls were recruited from the physical check unit of Taichung Veterans General Hospital (Taichung, Taiwan). All control subjects were given instruction on how to complete a 24-d diet recall. Vitamin B6 status was assessed by direct measures (plasma pyridoxal 5'-phosphate [PLP] and 4-pyridoxic acid) and indirect measures (erythrocyte alanine and aspartate aminotransferase activity coefficients). Levels of serum albumin, hemoglobin, hematocrit, high-sensitivity C-reactive protein, and immune responses (white blood cell, neutrophil, total lymphocytes, T lymphocytes [CD3], B lymphocytes [CD19], T-helper cells [CD4], and suppressor cells [CD8]) were determined.

RESULTS

Critically ill patients had sufficient vitamin B6 intake but showed marginal PLP deficiency (20.9 +/- 1.5 nmol/L). In addition, critically ill patients had significantly lower and abnormal immune responses than did healthy controls. There was no significant correlation of vitamin B6 intake and erythrocyte alanine and aspartate aminotransaminase activity coefficients with immune indices. Plasma PLP concentration was strongly negatively correlated with high-sensitivity C-reactive protein level. However, plasma PLP was significantly associated with immune responses after adjustment for age, sex, high-sensitivity C-reactive protein, and the other four vitamin B6 indicators.

CONCLUSIONS

Plasma PLP is a significant indicator of immune responses in human subjects. Further research is warranted to study whether vitamin B6 supplementation in critically ill patients improves their immune responses.

Authors+Show Affiliations

School of Nutrition, Chung Shan Medical University, Taichung, Taiwan, Republic of China. ych@csmu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15975484

Citation

Huang, Yi-Chia, et al. "Plasma Pyridoxal 5'-phosphate Is a Significant Indicator of Immune Responses in the Mechanically Ventilated Critically Ill." Nutrition (Burbank, Los Angeles County, Calif.), vol. 21, no. 7-8, 2005, pp. 779-85.
Huang YC, Chang HH, Huang SC, et al. Plasma pyridoxal 5'-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill. Nutrition. 2005;21(7-8):779-85.
Huang, Y. C., Chang, H. H., Huang, S. C., Cheng, C. H., Lee, B. J., Cheng, S. Y., & Su, K. H. (2005). Plasma pyridoxal 5'-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill. Nutrition (Burbank, Los Angeles County, Calif.), 21(7-8), 779-85.
Huang YC, et al. Plasma Pyridoxal 5'-phosphate Is a Significant Indicator of Immune Responses in the Mechanically Ventilated Critically Ill. Nutrition. 2005 Jul-Aug;21(7-8):779-85. PubMed PMID: 15975484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma pyridoxal 5'-phosphate is a significant indicator of immune responses in the mechanically ventilated critically ill. AU - Huang,Yi-Chia, AU - Chang,Han-Hsin, AU - Huang,Shih-Chien, AU - Cheng,Chien-Hsiung, AU - Lee,Bor-Jen, AU - Cheng,Su-Ya, AU - Su,Kuo-Hsiung, PY - 2004/06/20/received PY - 2004/11/04/accepted PY - 2005/6/25/pubmed PY - 2005/12/13/medline PY - 2005/6/25/entrez SP - 779 EP - 85 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 21 IS - 7-8 N2 - OBJECTIVES: This study assessed the effect of vitamin B6 status on immune responses in mechanically ventilated, critically ill patients and compared the results with those of healthy controls. METHODS: This was designed as a cross-sectional observational study. Forty patients in the intensive care unit successfully completed this study. Vitamin B6 intake was recorded for 8 d. Severity of illness (Second Acute Physiology and Chronic Health Evaluation score) was recorded. Thirty-eighty healthy controls were recruited from the physical check unit of Taichung Veterans General Hospital (Taichung, Taiwan). All control subjects were given instruction on how to complete a 24-d diet recall. Vitamin B6 status was assessed by direct measures (plasma pyridoxal 5'-phosphate [PLP] and 4-pyridoxic acid) and indirect measures (erythrocyte alanine and aspartate aminotransferase activity coefficients). Levels of serum albumin, hemoglobin, hematocrit, high-sensitivity C-reactive protein, and immune responses (white blood cell, neutrophil, total lymphocytes, T lymphocytes [CD3], B lymphocytes [CD19], T-helper cells [CD4], and suppressor cells [CD8]) were determined. RESULTS: Critically ill patients had sufficient vitamin B6 intake but showed marginal PLP deficiency (20.9 +/- 1.5 nmol/L). In addition, critically ill patients had significantly lower and abnormal immune responses than did healthy controls. There was no significant correlation of vitamin B6 intake and erythrocyte alanine and aspartate aminotransaminase activity coefficients with immune indices. Plasma PLP concentration was strongly negatively correlated with high-sensitivity C-reactive protein level. However, plasma PLP was significantly associated with immune responses after adjustment for age, sex, high-sensitivity C-reactive protein, and the other four vitamin B6 indicators. CONCLUSIONS: Plasma PLP is a significant indicator of immune responses in human subjects. Further research is warranted to study whether vitamin B6 supplementation in critically ill patients improves their immune responses. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/15975484/Plasma_pyridoxal_5'_phosphate_is_a_significant_indicator_of_immune_responses_in_the_mechanically_ventilated_critically_ill_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(05)00130-9 DB - PRIME DP - Unbound Medicine ER -