Tags

Type your tag names separated by a space and hit enter

Importance of the initial volume of parotid glands in xerostomia for patients with head and neck cancers treated with IMRT.
Jpn J Clin Oncol. 2005 Jul; 35(7):375-9.JJ

Abstract

OBJECTIVE

Our aim was to evaluate predictors of xerostomia in patients with head and neck cancers treated with intensity-modulated radiation therapy (IMRT).

METHODS

Thirty-three patients with pharyngeal cancer were evaluated for xerostomia after having been treated with IMRT. All patients were treated with whole-neck irradiation of 46-50 Gy by IMRT, followed by boost IMRT to the high-risk clinical target volume to a total dose of 56-70 Gy in 28-35 fractions (median, 68 Gy). For boost IMRT, a second computed tomography (CT-2) scan was done in the third to fourth week of IMRT. Xerostomia was scored 3-4 months after the start of IMRT.

RESULTS

The mean doses to the contralateral and ipsilateral parotid glands were 24.0 +/- 6.2 and 30.3 +/- 6.6 Gy, respectively. Among the 33 patients, xerostomia of grades 0, 1, 2 and 3 was noted in one, 18, 12 and two patients, respectively. Although the mean dose to the parotid glands was not correlated with the grade of xerostomia, the initial volume of the parotid glands was correlated with the grade of xerostomia (P = 0.04). Of 17 patients with small parotid glands (< or =38.8 ml) on initial CT (CT-1), 11 (65%) showed grade 2 or grade 3 xerostomia, whereas only three (19%) of 16 patients with larger parotid glands showed grade 2 xerostomia (P < 0.05). The mean volume of the parotid glands on CT-1 was 43.1 +/- 15.2 ml, but decreased significantly to 32.0 +/- 11.4 ml (74%) on CT-2 (P < 0.0001).

CONCLUSIONS

Initial volumes of the parotid glands are significantly correlated with the grade of xerostomia in patients treated with IMRT. The volume of the parotid glands decreased significantly during the course of IMRT.

Authors+Show Affiliations

Department of Radiation Oncology, Kinki University School of Medicine, Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan. ynishi@med.kindai.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15976068

Citation

Nishimura, Yasumasa, et al. "Importance of the Initial Volume of Parotid Glands in Xerostomia for Patients With Head and Neck Cancers Treated With IMRT." Japanese Journal of Clinical Oncology, vol. 35, no. 7, 2005, pp. 375-9.
Nishimura Y, Nakamatsu K, Shibata T, et al. Importance of the initial volume of parotid glands in xerostomia for patients with head and neck cancers treated with IMRT. Jpn J Clin Oncol. 2005;35(7):375-9.
Nishimura, Y., Nakamatsu, K., Shibata, T., Kanamori, S., Koike, R., Okumura, M., & Suzuki, M. (2005). Importance of the initial volume of parotid glands in xerostomia for patients with head and neck cancers treated with IMRT. Japanese Journal of Clinical Oncology, 35(7), 375-9.
Nishimura Y, et al. Importance of the Initial Volume of Parotid Glands in Xerostomia for Patients With Head and Neck Cancers Treated With IMRT. Jpn J Clin Oncol. 2005;35(7):375-9. PubMed PMID: 15976068.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Importance of the initial volume of parotid glands in xerostomia for patients with head and neck cancers treated with IMRT. AU - Nishimura,Yasumasa, AU - Nakamatsu,Kiyoshi, AU - Shibata,Toru, AU - Kanamori,Shuichi, AU - Koike,Ryuta, AU - Okumura,Masahiko, AU - Suzuki,Minoru, Y1 - 2005/06/23/ PY - 2005/6/25/pubmed PY - 2005/9/21/medline PY - 2005/6/25/entrez SP - 375 EP - 9 JF - Japanese journal of clinical oncology JO - Jpn J Clin Oncol VL - 35 IS - 7 N2 - OBJECTIVE: Our aim was to evaluate predictors of xerostomia in patients with head and neck cancers treated with intensity-modulated radiation therapy (IMRT). METHODS: Thirty-three patients with pharyngeal cancer were evaluated for xerostomia after having been treated with IMRT. All patients were treated with whole-neck irradiation of 46-50 Gy by IMRT, followed by boost IMRT to the high-risk clinical target volume to a total dose of 56-70 Gy in 28-35 fractions (median, 68 Gy). For boost IMRT, a second computed tomography (CT-2) scan was done in the third to fourth week of IMRT. Xerostomia was scored 3-4 months after the start of IMRT. RESULTS: The mean doses to the contralateral and ipsilateral parotid glands were 24.0 +/- 6.2 and 30.3 +/- 6.6 Gy, respectively. Among the 33 patients, xerostomia of grades 0, 1, 2 and 3 was noted in one, 18, 12 and two patients, respectively. Although the mean dose to the parotid glands was not correlated with the grade of xerostomia, the initial volume of the parotid glands was correlated with the grade of xerostomia (P = 0.04). Of 17 patients with small parotid glands (< or =38.8 ml) on initial CT (CT-1), 11 (65%) showed grade 2 or grade 3 xerostomia, whereas only three (19%) of 16 patients with larger parotid glands showed grade 2 xerostomia (P < 0.05). The mean volume of the parotid glands on CT-1 was 43.1 +/- 15.2 ml, but decreased significantly to 32.0 +/- 11.4 ml (74%) on CT-2 (P < 0.0001). CONCLUSIONS: Initial volumes of the parotid glands are significantly correlated with the grade of xerostomia in patients treated with IMRT. The volume of the parotid glands decreased significantly during the course of IMRT. SN - 0368-2811 UR - https://www.unboundmedicine.com/medline/citation/15976068/Importance_of_the_initial_volume_of_parotid_glands_in_xerostomia_for_patients_with_head_and_neck_cancers_treated_with_IMRT_ L2 - https://academic.oup.com/jjco/article-lookup/doi/10.1093/jjco/hyi108 DB - PRIME DP - Unbound Medicine ER -