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Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like Peptide-1.
Obes Res 2005; 13(6):1000-7OR

Abstract

OBJECTIVE

To analyze the putative interest of oligofructose (OFS) in the modulation of food intake after high-fat diet in rats and to question the relevance of the expression and secretion of intestinal peptides in that context.

RESEARCH METHODS AND PROCEDURES

Male Wistar rats were pretreated with standard diet or OFS-enriched (10%) standard diet for 35 days followed by 15 days of high-fat diet enriched or not with OFS (10%) treatment. Body weight, food intake, triglycerides, and plasma ghrelin levels were monitored during the treatment. On day 50, rats were food-deprived 8 hours and anesthetized for blood and intestinal tissue sampling for further proglucagon mRNA, glucagon-like peptide (GLP)-1, and GLP-2 quantification.

RESULTS

The addition of OFS in the diet protects against the promotion of energy intake, body weight gain, fat mass development, and serum triglyceride accumulation induced by a high-fat diet. OFS fermentation leads to an increase in proglucagon mRNA in the cecum and the colon and in GLP-1 and GLP-2 contents in the proximal colon, with consequences on the portal concentration of GLP-1 (increase). A lower ghrelin level is observed only when OFS is added to the standard diet of rats.

DISCUSSION

In rats exposed to high-fat diet, OFS is, thus, able to modulate endogenous production of gut peptides involved in appetite and body weight regulation. Because several approaches are currently used to treat type 2 diabetes and obesity with limited effectiveness, dietary fibers such as OFS, which promote the endogenous production of gut peptides like GLP-1, could be proposed as interesting nutrients to consider in the management of fat intake and associated metabolic disorders.

Authors+Show Affiliations

Université Catholique de Louvain-Unité de Pharmacocinétique, Metabolisme, Nutrition et Toxicologie 7369, 73 Avenue Mounier, B-1200 Brussels, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15976142

Citation

Cani, Patrice D., et al. "Oligofructose Promotes Satiety in Rats Fed a High-fat Diet: Involvement of Glucagon-like Peptide-1." Obesity Research, vol. 13, no. 6, 2005, pp. 1000-7.
Cani PD, Neyrinck AM, Maton N, et al. Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like Peptide-1. Obes Res. 2005;13(6):1000-7.
Cani, P. D., Neyrinck, A. M., Maton, N., & Delzenne, N. M. (2005). Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like Peptide-1. Obesity Research, 13(6), pp. 1000-7.
Cani PD, et al. Oligofructose Promotes Satiety in Rats Fed a High-fat Diet: Involvement of Glucagon-like Peptide-1. Obes Res. 2005;13(6):1000-7. PubMed PMID: 15976142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like Peptide-1. AU - Cani,Patrice D, AU - Neyrinck,Audrey M, AU - Maton,Nicole, AU - Delzenne,Nathalie M, PY - 2005/6/25/pubmed PY - 2005/10/21/medline PY - 2005/6/25/entrez SP - 1000 EP - 7 JF - Obesity research JO - Obes. Res. VL - 13 IS - 6 N2 - OBJECTIVE: To analyze the putative interest of oligofructose (OFS) in the modulation of food intake after high-fat diet in rats and to question the relevance of the expression and secretion of intestinal peptides in that context. RESEARCH METHODS AND PROCEDURES: Male Wistar rats were pretreated with standard diet or OFS-enriched (10%) standard diet for 35 days followed by 15 days of high-fat diet enriched or not with OFS (10%) treatment. Body weight, food intake, triglycerides, and plasma ghrelin levels were monitored during the treatment. On day 50, rats were food-deprived 8 hours and anesthetized for blood and intestinal tissue sampling for further proglucagon mRNA, glucagon-like peptide (GLP)-1, and GLP-2 quantification. RESULTS: The addition of OFS in the diet protects against the promotion of energy intake, body weight gain, fat mass development, and serum triglyceride accumulation induced by a high-fat diet. OFS fermentation leads to an increase in proglucagon mRNA in the cecum and the colon and in GLP-1 and GLP-2 contents in the proximal colon, with consequences on the portal concentration of GLP-1 (increase). A lower ghrelin level is observed only when OFS is added to the standard diet of rats. DISCUSSION: In rats exposed to high-fat diet, OFS is, thus, able to modulate endogenous production of gut peptides involved in appetite and body weight regulation. Because several approaches are currently used to treat type 2 diabetes and obesity with limited effectiveness, dietary fibers such as OFS, which promote the endogenous production of gut peptides like GLP-1, could be proposed as interesting nutrients to consider in the management of fat intake and associated metabolic disorders. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/15976142/Oligofructose_promotes_satiety_in_rats_fed_a_high_fat_diet:_involvement_of_glucagon_like_Peptide_1_ L2 - https://doi.org/10.1038/oby.2005.117 DB - PRIME DP - Unbound Medicine ER -