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The effect-site concentration of remifentanil blunting cardiovascular responses to tracheal intubation and skin incision during bispectral index-guided propofol anesthesia.
Anesth Analg. 2005 Jul; 101(1):125-30, table of contents.A&A

Abstract

We sought to determine the effect-site concentration of remifentanil blunting sympathetic responses to tracheal intubation and skin incision during bispectral index (BIS)-guided propofol anesthesia. Forty-one ASA physical status I-II patients, aged 20-65 yr and undergoing major abdominal surgery, were randomly assigned to one of two groups: tracheal intubation (group TI, n = 20) or skin incision (group SI, n = 21). All patients received a target-controlled infusion of propofol of 4 microg/mL, which was then adjusted to maintain a BIS value ranging between 40 and 50. The effect-site concentration of remifentanil blocking the sympathetic responses to tracheal intubation and skin incision in 50% of cases (Ce50) was determined using an up-and-down sequential allocation method. The mean (95% confidence interval [CI]) Ce50 of remifentanil was 5.0 ng/mL for TI (95% CI, 4.7-5.4 ng/mL) and 2.1 ng/mL for SI (95% CI, 1.4-2.8 ng/mL). This study shows that effect-site concentrations of remifentanil of 5 ng/mL and 2 ng/mL are effective in blunting sympathetic responses to tracheal intubation and skin incision in 50% of patients when combined with a BIS-guided target controlled infusion of propofol.

Authors+Show Affiliations

Department of Anesthesiology, IRCCS H San Raffaele, Via Olgettina 60, 20132 Milan, Italy. albertin.andrea@hsr.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15976218

Citation

Albertin, Andrea, et al. "The Effect-site Concentration of Remifentanil Blunting Cardiovascular Responses to Tracheal Intubation and Skin Incision During Bispectral Index-guided Propofol Anesthesia." Anesthesia and Analgesia, vol. 101, no. 1, 2005, 125-30, table of contents.
Albertin A, Casati A, Federica L, et al. The effect-site concentration of remifentanil blunting cardiovascular responses to tracheal intubation and skin incision during bispectral index-guided propofol anesthesia. Anesth Analg. 2005;101(1):125-30, table of contents.
Albertin, A., Casati, A., Federica, L., Roberto, V., Travaglini, V., Bergonzi, P., & Torri, G. (2005). The effect-site concentration of remifentanil blunting cardiovascular responses to tracheal intubation and skin incision during bispectral index-guided propofol anesthesia. Anesthesia and Analgesia, 101(1), 125-30, table of contents.
Albertin A, et al. The Effect-site Concentration of Remifentanil Blunting Cardiovascular Responses to Tracheal Intubation and Skin Incision During Bispectral Index-guided Propofol Anesthesia. Anesth Analg. 2005;101(1):125-30, table of contents. PubMed PMID: 15976218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect-site concentration of remifentanil blunting cardiovascular responses to tracheal intubation and skin incision during bispectral index-guided propofol anesthesia. AU - Albertin,Andrea, AU - Casati,Andrea, AU - Federica,Lombardo, AU - Roberto,Valeri, AU - Travaglini,Vittorino, AU - Bergonzi,Piercarlo, AU - Torri,Giorgio, PY - 2005/6/25/pubmed PY - 2005/7/13/medline PY - 2005/6/25/entrez SP - 125-30, table of contents JF - Anesthesia and analgesia JO - Anesth Analg VL - 101 IS - 1 N2 - We sought to determine the effect-site concentration of remifentanil blunting sympathetic responses to tracheal intubation and skin incision during bispectral index (BIS)-guided propofol anesthesia. Forty-one ASA physical status I-II patients, aged 20-65 yr and undergoing major abdominal surgery, were randomly assigned to one of two groups: tracheal intubation (group TI, n = 20) or skin incision (group SI, n = 21). All patients received a target-controlled infusion of propofol of 4 microg/mL, which was then adjusted to maintain a BIS value ranging between 40 and 50. The effect-site concentration of remifentanil blocking the sympathetic responses to tracheal intubation and skin incision in 50% of cases (Ce50) was determined using an up-and-down sequential allocation method. The mean (95% confidence interval [CI]) Ce50 of remifentanil was 5.0 ng/mL for TI (95% CI, 4.7-5.4 ng/mL) and 2.1 ng/mL for SI (95% CI, 1.4-2.8 ng/mL). This study shows that effect-site concentrations of remifentanil of 5 ng/mL and 2 ng/mL are effective in blunting sympathetic responses to tracheal intubation and skin incision in 50% of patients when combined with a BIS-guided target controlled infusion of propofol. SN - 0003-2999 UR - https://www.unboundmedicine.com/medline/citation/15976218/The_effect_site_concentration_of_remifentanil_blunting_cardiovascular_responses_to_tracheal_intubation_and_skin_incision_during_bispectral_index_guided_propofol_anesthesia_ L2 - https://doi.org/10.1213/01.ANE.0000153012.35120.FE DB - PRIME DP - Unbound Medicine ER -