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Driving under the influence of drugs -- evaluation of analytical data of drugs in oral fluid, serum and urine, and correlation with impairment symptoms.
Forensic Sci Int. 2005 Sep 10; 152(2-3):149-55.FS

Abstract

A study was performed to acquire urine, serum and oral fluid samples in cases of suspected driving under the influence of drugs of abuse. Oral fluid was collected using a novel sampling/testing device (Dräger DrugTest System). The aim of the study was to evaluate oral fluid and urine as a predictor of blood samples positive for drugs and impairment symptoms. Analysis for cannabinoids, amphetamine and its derivatives, opiates and cocaine was performed in urine using the Mahsan Kombi/DOA4-test, in serum using immunoassay and gas chromatography-mass spectrometry (GC-MS) confirmation and in oral fluid by GC-MS. Police and medical officer observations of impairment symptoms were rated and evaluated using a threshold value for the classification of driving inability. Accuracy in correlating drug detection in oral fluid and serum were >90% for all substances and also >90% in urine and serum except for THC (71.0%). Of the cases with oral fluid positive for any drug 97.1% of corresponding serum samples were also positive for at least one drug; of drug-positive urine samples this were only 82.4%. In 119 of 146 cases, impairment symptoms above threshold were observed (81.5%). Of the cases with drugs detected in serum, 19.1% appeared not impaired which were the same with drug-positive oral fluid while more persons with drug-positive urine samples appeared uninfluenced (32.7%). The data demonstrate that oral fluid is superior to urine in correlating with serum analytical data and impairment symptoms of drivers under the influence of drugs of abuse.

Authors+Show Affiliations

Institute of Forensic Toxicology, Center of Legal Medicine, Kennedyallee 104, D-60596 Frankfurt/Main, Germany. toennes@em.uni-frankfurt.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15978340

Citation

Toennes, Stefan W., et al. "Driving Under the Influence of Drugs -- Evaluation of Analytical Data of Drugs in Oral Fluid, Serum and Urine, and Correlation With Impairment Symptoms." Forensic Science International, vol. 152, no. 2-3, 2005, pp. 149-55.
Toennes SW, Kauert GF, Steinmeyer S, et al. Driving under the influence of drugs -- evaluation of analytical data of drugs in oral fluid, serum and urine, and correlation with impairment symptoms. Forensic Sci Int. 2005;152(2-3):149-55.
Toennes, S. W., Kauert, G. F., Steinmeyer, S., & Moeller, M. R. (2005). Driving under the influence of drugs -- evaluation of analytical data of drugs in oral fluid, serum and urine, and correlation with impairment symptoms. Forensic Science International, 152(2-3), 149-55.
Toennes SW, et al. Driving Under the Influence of Drugs -- Evaluation of Analytical Data of Drugs in Oral Fluid, Serum and Urine, and Correlation With Impairment Symptoms. Forensic Sci Int. 2005 Sep 10;152(2-3):149-55. PubMed PMID: 15978340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Driving under the influence of drugs -- evaluation of analytical data of drugs in oral fluid, serum and urine, and correlation with impairment symptoms. AU - Toennes,Stefan W, AU - Kauert,Gerold F, AU - Steinmeyer,Stefan, AU - Moeller,Manfred R, PY - 2003/11/28/received PY - 2004/08/02/revised PY - 2004/08/03/accepted PY - 2005/6/28/pubmed PY - 2005/9/9/medline PY - 2005/6/28/entrez SP - 149 EP - 55 JF - Forensic science international JO - Forensic Sci Int VL - 152 IS - 2-3 N2 - A study was performed to acquire urine, serum and oral fluid samples in cases of suspected driving under the influence of drugs of abuse. Oral fluid was collected using a novel sampling/testing device (Dräger DrugTest System). The aim of the study was to evaluate oral fluid and urine as a predictor of blood samples positive for drugs and impairment symptoms. Analysis for cannabinoids, amphetamine and its derivatives, opiates and cocaine was performed in urine using the Mahsan Kombi/DOA4-test, in serum using immunoassay and gas chromatography-mass spectrometry (GC-MS) confirmation and in oral fluid by GC-MS. Police and medical officer observations of impairment symptoms were rated and evaluated using a threshold value for the classification of driving inability. Accuracy in correlating drug detection in oral fluid and serum were >90% for all substances and also >90% in urine and serum except for THC (71.0%). Of the cases with oral fluid positive for any drug 97.1% of corresponding serum samples were also positive for at least one drug; of drug-positive urine samples this were only 82.4%. In 119 of 146 cases, impairment symptoms above threshold were observed (81.5%). Of the cases with drugs detected in serum, 19.1% appeared not impaired which were the same with drug-positive oral fluid while more persons with drug-positive urine samples appeared uninfluenced (32.7%). The data demonstrate that oral fluid is superior to urine in correlating with serum analytical data and impairment symptoms of drivers under the influence of drugs of abuse. SN - 0379-0738 UR - https://www.unboundmedicine.com/medline/citation/15978340/Driving_under_the_influence_of_drugs____evaluation_of_analytical_data_of_drugs_in_oral_fluid_serum_and_urine_and_correlation_with_impairment_symptoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(04)00443-8 DB - PRIME DP - Unbound Medicine ER -