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Haemodynamic effects of coffee and purified caffeine in normal volunteers: a placebo-controlled clinical study.
J Hum Hypertens 1992; 6(2):95-9JH

Abstract

In order to evaluate the effects of 'espresso' Italian coffee on resting flow, blood pressure, and peripheral resistance, 15 non-coffee drinking healthy volunteers received 2 cups of regular coffee, 200 mg purified caffeine or placebo in a latin square double-blind crossover protocol. Before and 30, 60, 90 and 120 min after ingestion, segmental resting flow and BP were measured and peripheral resistance was calculated. An echocardiogram was also performed before and 60 and 120 min after caffeine intake. Both regular coffee and caffeine produced a significant decrease in resting flow and a significant increase in resistance; both systolic and diastolic BP also increased, although not significantly. No variation was observed in heart rate and in cardiac contractility. Placebo (highly decaffeinated coffee for regular coffee and china bitter extract for caffeine) did not produce any haemodynamic effect. In five other healthy volunteers used to drinking more than 5 cups of coffee a day, coffee administration had no effect. These data demonstrate that the caffeine contained in espresso Italian coffee is a vasoconstrictor agent whose effects however are completely blunted in usual coffee drinkers as a consequence of adaptation.

Authors+Show Affiliations

Institute of Clinical Medicine, University of Padova, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1597852

Citation

Casiglia, E, et al. "Haemodynamic Effects of Coffee and Purified Caffeine in Normal Volunteers: a Placebo-controlled Clinical Study." Journal of Human Hypertension, vol. 6, no. 2, 1992, pp. 95-9.
Casiglia E, Paleari CD, Petucco S, et al. Haemodynamic effects of coffee and purified caffeine in normal volunteers: a placebo-controlled clinical study. J Hum Hypertens. 1992;6(2):95-9.
Casiglia, E., Paleari, C. D., Petucco, S., Bongiovì, S., Colangeli, G., Baccilieri, M. S., ... Pessina, A. C. (1992). Haemodynamic effects of coffee and purified caffeine in normal volunteers: a placebo-controlled clinical study. Journal of Human Hypertension, 6(2), pp. 95-9.
Casiglia E, et al. Haemodynamic Effects of Coffee and Purified Caffeine in Normal Volunteers: a Placebo-controlled Clinical Study. J Hum Hypertens. 1992;6(2):95-9. PubMed PMID: 1597852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Haemodynamic effects of coffee and purified caffeine in normal volunteers: a placebo-controlled clinical study. AU - Casiglia,E, AU - Paleari,C D, AU - Petucco,S, AU - Bongiovì,S, AU - Colangeli,G, AU - Baccilieri,M S, AU - Pavan,L, AU - Pernice,M, AU - Pessina,A C, PY - 1992/4/1/pubmed PY - 1992/4/1/medline PY - 1992/4/1/entrez SP - 95 EP - 9 JF - Journal of human hypertension JO - J Hum Hypertens VL - 6 IS - 2 N2 - In order to evaluate the effects of 'espresso' Italian coffee on resting flow, blood pressure, and peripheral resistance, 15 non-coffee drinking healthy volunteers received 2 cups of regular coffee, 200 mg purified caffeine or placebo in a latin square double-blind crossover protocol. Before and 30, 60, 90 and 120 min after ingestion, segmental resting flow and BP were measured and peripheral resistance was calculated. An echocardiogram was also performed before and 60 and 120 min after caffeine intake. Both regular coffee and caffeine produced a significant decrease in resting flow and a significant increase in resistance; both systolic and diastolic BP also increased, although not significantly. No variation was observed in heart rate and in cardiac contractility. Placebo (highly decaffeinated coffee for regular coffee and china bitter extract for caffeine) did not produce any haemodynamic effect. In five other healthy volunteers used to drinking more than 5 cups of coffee a day, coffee administration had no effect. These data demonstrate that the caffeine contained in espresso Italian coffee is a vasoconstrictor agent whose effects however are completely blunted in usual coffee drinkers as a consequence of adaptation. SN - 0950-9240 UR - https://www.unboundmedicine.com/medline/citation/1597852/Haemodynamic_effects_of_coffee_and_purified_caffeine_in_normal_volunteers:_a_placebo_controlled_clinical_study_ L2 - https://medlineplus.gov/caffeine.html DB - PRIME DP - Unbound Medicine ER -