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Comparative evaluation of magnetization transfer contrast and fluid attenuated inversion recovery sequences in brain tuberculoma.
Clin Radiol. 2005 Jul; 60(7):787-93.CR

Abstract

AIM

To compare T1-weighted magnetization transfer (MT) with fluid attenuated inversion recovery (FLAIR) imaging for evaluating conspicuity and number of lesions in individuals with brain tuberculoma.

MATERIALS AND METHODS

In all 28 patients with brain tuberculoma underwent MR examination using fast spin-echo (FSE) T2, spin-echo (SE) T1, T1-weighted MT and FLAIR imaging. Post-contrast T1-weighted MT imaging was taken as the gold standard for assessing the number of lesions. Tuberculomas detected both on T1-weighted MT and FLAIR imaging were examined for the wall to be defined, and were divided into two groups on the basis of presence (group 1) or absence (group 2) of perilesional oedema visible on FLAIR imaging. The mean signal intensity of the wall of the lesions and adjacent oedema or brain parenchyma was analyzed qualitatively and quantitatively.

RESULTS

The number of lesions detected on T1-weighted MT was higher than on FLAIR imaging (209 versus 163). Conspicuity in both groups was better on T1-weighted MT images qualitatively as well as quantitatively. The difference in the signal intensity of the wall of the lesion and perilesional oedema was statistically significant only on T1-weighted MT images in group 1 (p=0.0003 versus 0.3), whereas in group 2 it was statistically significant both on T1-weighted MT and FLAIR imaging (p=0.009 versus 0.05).

CONCLUSION

FLAIR imaging is not helpful in the examination of brain tuberculomas compared with T1-weighted MT imaging, as it neither contributes to the characterization of lesion nor assesses the true disease load.

Authors+Show Affiliations

Department of Radiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

15978890

Citation

Saxena, S, et al. "Comparative Evaluation of Magnetization Transfer Contrast and Fluid Attenuated Inversion Recovery Sequences in Brain Tuberculoma." Clinical Radiology, vol. 60, no. 7, 2005, pp. 787-93.
Saxena S, Prakash M, Kumar S, et al. Comparative evaluation of magnetization transfer contrast and fluid attenuated inversion recovery sequences in brain tuberculoma. Clin Radiol. 2005;60(7):787-93.
Saxena, S., Prakash, M., Kumar, S., & Gupta, R. K. (2005). Comparative evaluation of magnetization transfer contrast and fluid attenuated inversion recovery sequences in brain tuberculoma. Clinical Radiology, 60(7), 787-93.
Saxena S, et al. Comparative Evaluation of Magnetization Transfer Contrast and Fluid Attenuated Inversion Recovery Sequences in Brain Tuberculoma. Clin Radiol. 2005;60(7):787-93. PubMed PMID: 15978890.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative evaluation of magnetization transfer contrast and fluid attenuated inversion recovery sequences in brain tuberculoma. AU - Saxena,S, AU - Prakash,M, AU - Kumar,S, AU - Gupta,R K, PY - 2004/05/11/received PY - 2004/09/10/revised PY - 2004/09/20/accepted PY - 2005/6/28/pubmed PY - 2005/9/1/medline PY - 2005/6/28/entrez SP - 787 EP - 93 JF - Clinical radiology JO - Clin Radiol VL - 60 IS - 7 N2 - AIM: To compare T1-weighted magnetization transfer (MT) with fluid attenuated inversion recovery (FLAIR) imaging for evaluating conspicuity and number of lesions in individuals with brain tuberculoma. MATERIALS AND METHODS: In all 28 patients with brain tuberculoma underwent MR examination using fast spin-echo (FSE) T2, spin-echo (SE) T1, T1-weighted MT and FLAIR imaging. Post-contrast T1-weighted MT imaging was taken as the gold standard for assessing the number of lesions. Tuberculomas detected both on T1-weighted MT and FLAIR imaging were examined for the wall to be defined, and were divided into two groups on the basis of presence (group 1) or absence (group 2) of perilesional oedema visible on FLAIR imaging. The mean signal intensity of the wall of the lesions and adjacent oedema or brain parenchyma was analyzed qualitatively and quantitatively. RESULTS: The number of lesions detected on T1-weighted MT was higher than on FLAIR imaging (209 versus 163). Conspicuity in both groups was better on T1-weighted MT images qualitatively as well as quantitatively. The difference in the signal intensity of the wall of the lesion and perilesional oedema was statistically significant only on T1-weighted MT images in group 1 (p=0.0003 versus 0.3), whereas in group 2 it was statistically significant both on T1-weighted MT and FLAIR imaging (p=0.009 versus 0.05). CONCLUSION: FLAIR imaging is not helpful in the examination of brain tuberculomas compared with T1-weighted MT imaging, as it neither contributes to the characterization of lesion nor assesses the true disease load. SN - 0009-9260 UR - https://www.unboundmedicine.com/medline/citation/15978890/Comparative_evaluation_of_magnetization_transfer_contrast_and_fluid_attenuated_inversion_recovery_sequences_in_brain_tuberculoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9260(05)00071-1 DB - PRIME DP - Unbound Medicine ER -