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Primitive neuroectodermal tumor of the cervix uteri: a case report -- changing concepts in therapy.
Gynecol Oncol. 2005 Sep; 98(3):516-9.GO

Abstract

BACKGROUND

Peripheral primitive neuroectodermal tumor (PNET) of the cervix uteri is extremely rare. Between 1987 and 2002, there have been eight cases described in the English literature. The treatment policies in these eight cases differed considerably, partly due to the rarity of the disease and to differing time periods of diagnosis and treatment.

CASE

At the end of 2002, a 21-year-old woman presented with a PNET of the cervix uteri at our institute, the Erasmus Medical Center. For the appropriate treatment in this case, we reviewed the literature and decided that the treatment should be different from the local surgical treatment followed by additional treatments as most of the earlier reports describe.

CONCLUSION

In view of the current knowledge of PNET belonging to the family of Ewing's sarcoma, and the improvement of treatment outcome in these tumors due to dose-intensive neo-adjuvant chemotherapy, patients with PNET of the cervix should be treated in accordance to the protocol for bony Ewing's sarcoma with multimodality therapy by means of induction chemotherapy, surgery, and consolidation chemotherapy.

Authors+Show Affiliations

Erasmus University Medical Center, Daniel den Hoed Cancer Center, PO-Box 5201, 3008 AE Rotterdam, The Netherlands. a.snijders-keilholz@erasmusmc.nlNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

15979131

Citation

Snijders-Keilholz, A, et al. "Primitive Neuroectodermal Tumor of the Cervix Uteri: a Case Report -- Changing Concepts in Therapy." Gynecologic Oncology, vol. 98, no. 3, 2005, pp. 516-9.
Snijders-Keilholz A, Ewing P, Seynaeve C, et al. Primitive neuroectodermal tumor of the cervix uteri: a case report -- changing concepts in therapy. Gynecol Oncol. 2005;98(3):516-9.
Snijders-Keilholz, A., Ewing, P., Seynaeve, C., & Burger, C. W. (2005). Primitive neuroectodermal tumor of the cervix uteri: a case report -- changing concepts in therapy. Gynecologic Oncology, 98(3), 516-9.
Snijders-Keilholz A, et al. Primitive Neuroectodermal Tumor of the Cervix Uteri: a Case Report -- Changing Concepts in Therapy. Gynecol Oncol. 2005;98(3):516-9. PubMed PMID: 15979131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primitive neuroectodermal tumor of the cervix uteri: a case report -- changing concepts in therapy. AU - Snijders-Keilholz,A, AU - Ewing,P, AU - Seynaeve,C, AU - Burger,C W, PY - 2005/01/07/received PY - 2005/05/03/accepted PY - 2005/6/28/pubmed PY - 2005/11/3/medline PY - 2005/6/28/entrez SP - 516 EP - 9 JF - Gynecologic oncology JO - Gynecol Oncol VL - 98 IS - 3 N2 - BACKGROUND: Peripheral primitive neuroectodermal tumor (PNET) of the cervix uteri is extremely rare. Between 1987 and 2002, there have been eight cases described in the English literature. The treatment policies in these eight cases differed considerably, partly due to the rarity of the disease and to differing time periods of diagnosis and treatment. CASE: At the end of 2002, a 21-year-old woman presented with a PNET of the cervix uteri at our institute, the Erasmus Medical Center. For the appropriate treatment in this case, we reviewed the literature and decided that the treatment should be different from the local surgical treatment followed by additional treatments as most of the earlier reports describe. CONCLUSION: In view of the current knowledge of PNET belonging to the family of Ewing's sarcoma, and the improvement of treatment outcome in these tumors due to dose-intensive neo-adjuvant chemotherapy, patients with PNET of the cervix should be treated in accordance to the protocol for bony Ewing's sarcoma with multimodality therapy by means of induction chemotherapy, surgery, and consolidation chemotherapy. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/15979131/Primitive_neuroectodermal_tumor_of_the_cervix_uteri:_a_case_report____changing_concepts_in_therapy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(05)00386-0 DB - PRIME DP - Unbound Medicine ER -