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Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats.
Reprod Toxicol. 2006 Jan; 21(1):42-7.RT

Abstract

The aim of this study was to investigate the possible protective role of lycopene on cisplatin (CP)-induced spermiotoxicity using quantitative, biochemical and histopathological approaches. Adult male Sprague-Dawley rats were randomly divided into four groups. The control group received physiological saline; animals in cisplatin group received only cisplatin; pre-treatment group received a 10-day of lycopene before administration of cisplatin while animals in post-treatment group received a 5-day of lycopene following administration of cisplatin. Cisplatin (7 mg kg(-1)) was intraperitoneally (i.p.) injected as a single dose and lycopene (4 mg kg(-1)) was administered by gavage in corn oil. Traits of reproductive organs; sperm characteristics, testicular histological findings, plasma testosterone levels and the testicular tissue oxidative status were determined. Administration of cisplatin to rats decreased sperm concentration (p < 0.05) and sperm motility (p < 0.001), increased total abnormal sperm rates (p < 0.05) as compared with the control group. While a marked normalization was achieved only in sperm concentration with lycopene in pre-treatment group, significant normalizations were achieved in the sperm concentration, sperm motility, total abnormal sperm rates in post-treatment group. No significant differences in levels of testosterone were observed among all groups. An increase in testes malondialdehyde concentrations (p < 0.05) and glutathione peroxidase activities (p < 0.001) were detected while significant decreases in glutathione levels (p < 0.001) in cisplatin alone group when compared to control group. While pre-treatment with lycopene restoring only malondialdehyde concentrations, its post-treatment caused normalization in both malondialdehyde and glutathione levels when compared with the cisplatin alone group. On the other hand, significant increases were determined in GSH-Px activities in all experimental groups when compared with the control group. Although the mechanism is not clear, the results from this experimental study suggest that the lycopene have a possible protective effect against cisplatin-induced spermiotoxicity, effect of giving lycopene after cisplatin being superior to the giving it before cisplatin.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Firat University, 23119 Elaziğ, Turkey. aatessahin@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15979841

Citation

Ateşşahin, Ahmet, et al. "Protective Role of Lycopene On Cisplatin-induced Changes in Sperm Characteristics, Testicular Damage and Oxidative Stress in Rats." Reproductive Toxicology (Elmsford, N.Y.), vol. 21, no. 1, 2006, pp. 42-7.
Ateşşahin A, Karahan I, Türk G, et al. Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats. Reprod Toxicol. 2006;21(1):42-7.
Ateşşahin, A., Karahan, I., Türk, G., Gür, S., Yilmaz, S., & Ceribaşi, A. O. (2006). Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats. Reproductive Toxicology (Elmsford, N.Y.), 21(1), 42-7.
Ateşşahin A, et al. Protective Role of Lycopene On Cisplatin-induced Changes in Sperm Characteristics, Testicular Damage and Oxidative Stress in Rats. Reprod Toxicol. 2006;21(1):42-7. PubMed PMID: 15979841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats. AU - Ateşşahin,Ahmet, AU - Karahan,Izzet, AU - Türk,Gaffari, AU - Gür,Seyfettin, AU - Yilmaz,Seval, AU - Ceribaşi,Ali Osman, Y1 - 2005/06/24/ PY - 2004/12/27/received PY - 2005/05/02/revised PY - 2005/05/16/accepted PY - 2005/6/28/pubmed PY - 2006/3/11/medline PY - 2005/6/28/entrez SP - 42 EP - 7 JF - Reproductive toxicology (Elmsford, N.Y.) JO - Reprod Toxicol VL - 21 IS - 1 N2 - The aim of this study was to investigate the possible protective role of lycopene on cisplatin (CP)-induced spermiotoxicity using quantitative, biochemical and histopathological approaches. Adult male Sprague-Dawley rats were randomly divided into four groups. The control group received physiological saline; animals in cisplatin group received only cisplatin; pre-treatment group received a 10-day of lycopene before administration of cisplatin while animals in post-treatment group received a 5-day of lycopene following administration of cisplatin. Cisplatin (7 mg kg(-1)) was intraperitoneally (i.p.) injected as a single dose and lycopene (4 mg kg(-1)) was administered by gavage in corn oil. Traits of reproductive organs; sperm characteristics, testicular histological findings, plasma testosterone levels and the testicular tissue oxidative status were determined. Administration of cisplatin to rats decreased sperm concentration (p < 0.05) and sperm motility (p < 0.001), increased total abnormal sperm rates (p < 0.05) as compared with the control group. While a marked normalization was achieved only in sperm concentration with lycopene in pre-treatment group, significant normalizations were achieved in the sperm concentration, sperm motility, total abnormal sperm rates in post-treatment group. No significant differences in levels of testosterone were observed among all groups. An increase in testes malondialdehyde concentrations (p < 0.05) and glutathione peroxidase activities (p < 0.001) were detected while significant decreases in glutathione levels (p < 0.001) in cisplatin alone group when compared to control group. While pre-treatment with lycopene restoring only malondialdehyde concentrations, its post-treatment caused normalization in both malondialdehyde and glutathione levels when compared with the cisplatin alone group. On the other hand, significant increases were determined in GSH-Px activities in all experimental groups when compared with the control group. Although the mechanism is not clear, the results from this experimental study suggest that the lycopene have a possible protective effect against cisplatin-induced spermiotoxicity, effect of giving lycopene after cisplatin being superior to the giving it before cisplatin. SN - 0890-6238 UR - https://www.unboundmedicine.com/medline/citation/15979841/Protective_role_of_lycopene_on_cisplatin_induced_changes_in_sperm_characteristics_testicular_damage_and_oxidative_stress_in_rats_ DB - PRIME DP - Unbound Medicine ER -