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Two cases of cutaneous cryptococcosis.
Mycoses. 2005 Jul; 48(4):238-41.M

Abstract

We report two cases of cutaneous cryptococcosis in male patients without underlying disease. Case 1 had a granulomatous mass on his right neck, gradually enlarging for 3 months. After the mass was debrided surgically in a hospital, the incision wound gradually developed into a severe ulceration. Mycological examination revealed Cryptococcus neoformans infection. It was significant that histopathology of both pre-surgery granuloma and post-surgery ulceration revealed thick-walled spores with thick capsule. Chest X-ray revealed a shadow in the left lower lung. After treatment with amphotec for 21 days, the lesion healed. Case 2 had an approximately 2 x 2 cm solitary dull nodule on his right thigh, which had been present for 8 months. Mycological examination confirmed that the lesion was caused by C. neoformans. The patient's ratio of peripheral blood CD4(+) cell was slightly reduced. After 14 days of treatment with oral fluconazole, followed by oral itraconazole for 2 months, mycological and clinical cure were achieved. The two isolates were identified as C. neoformans var. gattii serotype C and C. neoformans var. grubii serotype A.

Authors+Show Affiliations

Xiujiao X
Department of Dermatology, 3rd Hospital, Hangzhou, China. xiaxiujiao@hz.cn
Ai'e X
No affiliation info available

MeSH

AdultAmphotericin BAntifungal AgentsCryptococcosisCryptococcus neoformansDermatomycosesFluconazoleGranulomaHumansItraconazoleMaleNeckSpores, FungalThigh

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

15982204

Citation

Xiujiao, Xia, and Xu Ai'e. "Two Cases of Cutaneous Cryptococcosis." Mycoses, vol. 48, no. 4, 2005, pp. 238-41.
Xiujiao X, Ai'e X. Two cases of cutaneous cryptococcosis. Mycoses. 2005;48(4):238-41.
Xiujiao, X., & Ai'e, X. (2005). Two cases of cutaneous cryptococcosis. Mycoses, 48(4), 238-41.
Xiujiao X, Ai'e X. Two Cases of Cutaneous Cryptococcosis. Mycoses. 2005;48(4):238-41. PubMed PMID: 15982204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two cases of cutaneous cryptococcosis. AU - Xiujiao,Xia, AU - Ai'e,Xu, PY - 2005/6/29/pubmed PY - 2005/9/24/medline PY - 2005/6/29/entrez SP - 238 EP - 41 JF - Mycoses JO - Mycoses VL - 48 IS - 4 N2 - We report two cases of cutaneous cryptococcosis in male patients without underlying disease. Case 1 had a granulomatous mass on his right neck, gradually enlarging for 3 months. After the mass was debrided surgically in a hospital, the incision wound gradually developed into a severe ulceration. Mycological examination revealed Cryptococcus neoformans infection. It was significant that histopathology of both pre-surgery granuloma and post-surgery ulceration revealed thick-walled spores with thick capsule. Chest X-ray revealed a shadow in the left lower lung. After treatment with amphotec for 21 days, the lesion healed. Case 2 had an approximately 2 x 2 cm solitary dull nodule on his right thigh, which had been present for 8 months. Mycological examination confirmed that the lesion was caused by C. neoformans. The patient's ratio of peripheral blood CD4(+) cell was slightly reduced. After 14 days of treatment with oral fluconazole, followed by oral itraconazole for 2 months, mycological and clinical cure were achieved. The two isolates were identified as C. neoformans var. gattii serotype C and C. neoformans var. grubii serotype A. SN - 0933-7407 UR - https://www.unboundmedicine.com/medline/citation/15982204/Two_cases_of_cutaneous_cryptococcosis_ DB - PRIME DP - Unbound Medicine ER -