Tags

Type your tag names separated by a space and hit enter

Features of the metabolic syndrome of "hypertriglyceridemic waist" and transplant coronary artery disease.
J Heart Lung Transplant. 2005 Jul; 24(7):819-26.JH

Abstract

BACKGROUND

This study evaluated the prevalence of the atherogenic metabolic triad and the hypothesis that waist circumference and fasting triglyceride concentrations could be used as screening tools for identification of the atherogenic metabolic triad in a population of heart transplant men. It also evaluated the relationship between the atherogenic metabolic triad and coronary artery disease (CAD).

METHODS

In the study group of 83 consecutive male heart transplant patients having their routine annual coronarography, 23 patients (28%) were characterized by the atherogenic metabolic triad defined by the presence of elevated fasting insulin and apolipoprotein B concentrations and by small low-density lipoprotein (LDL) particles.

RESULTS

Seventy-seven per cent of patients with waist circumference values >/= 90 cm and with elevated triglyceride levels (>/=2.0 mmol/liter) were characterized by this atherogenic metabolic triad. Patients with the atherogenic metabolic triad were at markedly increased risk of CAD (odds ratio of 25.3, 95% CI: 1.11-577.3, p < 0.04) compared to heart transplant patients without the atherogenic metabolic triad.

CONCLUSIONS

About 30% of heart transplant patients showed the features of the atherogenic metabolic triad. Measurement and interpretation of waist circumference and fasting triglycerides could be used among heart transplant patients to early identify men characterized by the presence of elevated fasting insulin and apolipoprotein B concentrations and small LDL particles. The presence of the atherogenic metabolic triad identified patients at high risk of CAD even in the heart transplant population.

Authors+Show Affiliations

Québec Heart Institute, Laval Hospital Research Center, Ste-Foy, Québec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15982608

Citation

Sénéchal, Mario, et al. "Features of the Metabolic Syndrome of "hypertriglyceridemic Waist" and Transplant Coronary Artery Disease." The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation, vol. 24, no. 7, 2005, pp. 819-26.
Sénéchal M, Lemieux I, Beucler I, et al. Features of the metabolic syndrome of "hypertriglyceridemic waist" and transplant coronary artery disease. J Heart Lung Transplant. 2005;24(7):819-26.
Sénéchal, M., Lemieux, I., Beucler, I., Drobinski, G., Cormont, S., Dubois, M., Gandjbakhch, I., Després, J. P., & Dorent, R. (2005). Features of the metabolic syndrome of "hypertriglyceridemic waist" and transplant coronary artery disease. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation, 24(7), 819-26.
Sénéchal M, et al. Features of the Metabolic Syndrome of "hypertriglyceridemic Waist" and Transplant Coronary Artery Disease. J Heart Lung Transplant. 2005;24(7):819-26. PubMed PMID: 15982608.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Features of the metabolic syndrome of "hypertriglyceridemic waist" and transplant coronary artery disease. AU - Sénéchal,Mario, AU - Lemieux,Isabelle, AU - Beucler,Isabel, AU - Drobinski,Gerard, AU - Cormont,Sylvie, AU - Dubois,Michelle, AU - Gandjbakhch,Iradj, AU - Després,Jean-Pierre, AU - Dorent,Richard, PY - 2004/02/02/received PY - 2004/05/09/accepted PY - 2005/6/29/pubmed PY - 2006/7/14/medline PY - 2005/6/29/entrez SP - 819 EP - 26 JF - The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation JO - J Heart Lung Transplant VL - 24 IS - 7 N2 - BACKGROUND: This study evaluated the prevalence of the atherogenic metabolic triad and the hypothesis that waist circumference and fasting triglyceride concentrations could be used as screening tools for identification of the atherogenic metabolic triad in a population of heart transplant men. It also evaluated the relationship between the atherogenic metabolic triad and coronary artery disease (CAD). METHODS: In the study group of 83 consecutive male heart transplant patients having their routine annual coronarography, 23 patients (28%) were characterized by the atherogenic metabolic triad defined by the presence of elevated fasting insulin and apolipoprotein B concentrations and by small low-density lipoprotein (LDL) particles. RESULTS: Seventy-seven per cent of patients with waist circumference values >/= 90 cm and with elevated triglyceride levels (>/=2.0 mmol/liter) were characterized by this atherogenic metabolic triad. Patients with the atherogenic metabolic triad were at markedly increased risk of CAD (odds ratio of 25.3, 95% CI: 1.11-577.3, p < 0.04) compared to heart transplant patients without the atherogenic metabolic triad. CONCLUSIONS: About 30% of heart transplant patients showed the features of the atherogenic metabolic triad. Measurement and interpretation of waist circumference and fasting triglycerides could be used among heart transplant patients to early identify men characterized by the presence of elevated fasting insulin and apolipoprotein B concentrations and small LDL particles. The presence of the atherogenic metabolic triad identified patients at high risk of CAD even in the heart transplant population. SN - 1053-2498 UR - https://www.unboundmedicine.com/medline/citation/15982608/Features_of_the_metabolic_syndrome_of_"hypertriglyceridemic_waist"_and_transplant_coronary_artery_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-2498(04)00284-0 DB - PRIME DP - Unbound Medicine ER -