Tags

Type your tag names separated by a space and hit enter

C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study.
Circulation. 2005 Jul 05; 112(1):25-31.Circ

Abstract

BACKGROUND

High C-reactive protein (CRP) is associated with increased coronary heart disease risk. Few long-term data in the elderly are available.

METHODS AND RESULTS

Baseline CRP was measured in 3971 men and women > or =65 years of age without prior vascular diseases; 26% had elevated concentrations (>3 mg/L). With 10 years of follow-up, 547 participants developed coronary heart disease (CHD; defined as myocardial infarction or coronary death). With elevated CRP, the 10-year cumulative CHD incidences were 33% in men and 17% in women. The age-, ethnicity-, and sex-adjusted relative risk of CHD for CRP >3 mg/L compared with <1 mg/L was 1.82 (95% CI, 1.46 to 2.28). Adjusting for conventional risk factors reduced the relative risk to 1.45 (95% CI, 1.14 to 1.86). The population-attributable risk of CHD for elevated CRP was 11%. Risk relationships did not differ in subgroups defined by baseline risk factors. We assessed whether CRP improved prediction by the Framingham Risk Score. Among men with a 10-year Framingham-predicted risk of 10% to 20%, the observed CHD incidence was 32% for elevated CRP. Among women, CRP discriminated best among those with a 10-year predicted risk >20%; the incidences were 31% and 10% for elevated and normal CRP levels, respectively.

CONCLUSIONS

In older men and women, elevated CRP was associated with increased 10-year risk of CHD, regardless of the presence or absence of cardiac risk factors. A single CRP measurement provided information beyond conventional risk assessment, especially in intermediate-Framingham-risk men and high-Framingham-risk women.

Authors+Show Affiliations

Department of Medicine, University of Vermont, Burlington, VT, USA. mary.cushman@uvm.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15983251

Citation

Cushman, Mary, et al. "C-reactive Protein and the 10-year Incidence of Coronary Heart Disease in Older Men and Women: the Cardiovascular Health Study." Circulation, vol. 112, no. 1, 2005, pp. 25-31.
Cushman M, Arnold AM, Psaty BM, et al. C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study. Circulation. 2005;112(1):25-31.
Cushman, M., Arnold, A. M., Psaty, B. M., Manolio, T. A., Kuller, L. H., Burke, G. L., Polak, J. F., & Tracy, R. P. (2005). C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study. Circulation, 112(1), 25-31.
Cushman M, et al. C-reactive Protein and the 10-year Incidence of Coronary Heart Disease in Older Men and Women: the Cardiovascular Health Study. Circulation. 2005 Jul 5;112(1):25-31. PubMed PMID: 15983251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C-reactive protein and the 10-year incidence of coronary heart disease in older men and women: the cardiovascular health study. AU - Cushman,Mary, AU - Arnold,Alice M, AU - Psaty,Bruce M, AU - Manolio,Teri A, AU - Kuller,Lewis H, AU - Burke,Gregory L, AU - Polak,Joseph F, AU - Tracy,Russell P, Y1 - 2005/06/27/ PY - 2005/6/29/pubmed PY - 2006/2/4/medline PY - 2005/6/29/entrez SP - 25 EP - 31 JF - Circulation JO - Circulation VL - 112 IS - 1 N2 - BACKGROUND: High C-reactive protein (CRP) is associated with increased coronary heart disease risk. Few long-term data in the elderly are available. METHODS AND RESULTS: Baseline CRP was measured in 3971 men and women > or =65 years of age without prior vascular diseases; 26% had elevated concentrations (>3 mg/L). With 10 years of follow-up, 547 participants developed coronary heart disease (CHD; defined as myocardial infarction or coronary death). With elevated CRP, the 10-year cumulative CHD incidences were 33% in men and 17% in women. The age-, ethnicity-, and sex-adjusted relative risk of CHD for CRP >3 mg/L compared with <1 mg/L was 1.82 (95% CI, 1.46 to 2.28). Adjusting for conventional risk factors reduced the relative risk to 1.45 (95% CI, 1.14 to 1.86). The population-attributable risk of CHD for elevated CRP was 11%. Risk relationships did not differ in subgroups defined by baseline risk factors. We assessed whether CRP improved prediction by the Framingham Risk Score. Among men with a 10-year Framingham-predicted risk of 10% to 20%, the observed CHD incidence was 32% for elevated CRP. Among women, CRP discriminated best among those with a 10-year predicted risk >20%; the incidences were 31% and 10% for elevated and normal CRP levels, respectively. CONCLUSIONS: In older men and women, elevated CRP was associated with increased 10-year risk of CHD, regardless of the presence or absence of cardiac risk factors. A single CRP measurement provided information beyond conventional risk assessment, especially in intermediate-Framingham-risk men and high-Framingham-risk women. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/15983251/C_reactive_protein_and_the_10_year_incidence_of_coronary_heart_disease_in_older_men_and_women:_the_cardiovascular_health_study_ L2 - http://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.104.504159?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -