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Extended-spectrum beta-lactamases in urinary isolates of Escherichia coli, Klebsiella pneumoniae and other gram-negative bacteria in a hospital in Eastern Province, Saudi Arabia.
Saudi Med J. 2005 Jun; 26(6):956-9.SM

Abstract

OBJECTIVE

To evaluate the prevalence and antimicrobial susceptibility of extended spectrum beta-lactamase (ESBL) producing gram-negative organisms isolated from patients with urinary tract infection (UTI).

METHODS

We carried out this study at Almana General Hospital, Eastern Province, Kingdom of Saudi Arabia, during the period August 2003 to October 2004. We studied urinary isolates of Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumoniae), Enterobacter spp and Pseudomonas aeruginosa (P. aeruginosa) for ESBL production and antimicrobial susceptibility.

RESULTS

We studied a total of 2302 urinary gram-negative isolates for the presence of ceftazidime resistance and ESBL. The isolates included E. coli (1238), K. pneumoniae (522), Enterobacter spp (138) and P. aeruginosa (404). Of the 2302 isolates, 232 (10%) were ceftazidime resistant and 204 (8.9%) were ESBL producers. We detected ESBL in 119 (9.6%) E. coli, 59 (11.3%) K. pneumoniae, 14 (10.14%) Enterobacter species and 12 (2.97%) P. aeruginosa isolates. The ESBL-producing strains were most commonly isolated from patients with indwelling Foley s catheter [131 (64.2%)] and those in the long-term care ward [90 (44.2%)]. Only 26 (12.7%) ESBL-producing isolates were from outpatients. More than 89% of the ESBL producers were susceptible to imipenem and meropenem. Amikacin and piperacillin/tazobactam were active against 68% and 45% of the isolates. Susceptibility to gentamicin and ciprofloxacin was 22.5% and 14%. The least active antibiotic was cefepime (11.8%).

CONCLUSION

This study shows the presence of ESBL producers in uropathogens from both inpatients and outpatients and demonstrates their high resistance to various classes of antimicrobial agents.

Authors+Show Affiliations

Department of Clinical Microbiology, Almana General Hospital, PO Box 1364, Alkhobar 31952, Kingdom of Saudi Arabia. aakader@doctor.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15983682

Citation

Kader, Abdulrahman A., and Kumar Angamuthu. "Extended-spectrum Beta-lactamases in Urinary Isolates of Escherichia Coli, Klebsiella Pneumoniae and Other Gram-negative Bacteria in a Hospital in Eastern Province, Saudi Arabia." Saudi Medical Journal, vol. 26, no. 6, 2005, pp. 956-9.
Kader AA, Angamuthu K. Extended-spectrum beta-lactamases in urinary isolates of Escherichia coli, Klebsiella pneumoniae and other gram-negative bacteria in a hospital in Eastern Province, Saudi Arabia. Saudi Med J. 2005;26(6):956-9.
Kader, A. A., & Angamuthu, K. (2005). Extended-spectrum beta-lactamases in urinary isolates of Escherichia coli, Klebsiella pneumoniae and other gram-negative bacteria in a hospital in Eastern Province, Saudi Arabia. Saudi Medical Journal, 26(6), 956-9.
Kader AA, Angamuthu K. Extended-spectrum Beta-lactamases in Urinary Isolates of Escherichia Coli, Klebsiella Pneumoniae and Other Gram-negative Bacteria in a Hospital in Eastern Province, Saudi Arabia. Saudi Med J. 2005;26(6):956-9. PubMed PMID: 15983682.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extended-spectrum beta-lactamases in urinary isolates of Escherichia coli, Klebsiella pneumoniae and other gram-negative bacteria in a hospital in Eastern Province, Saudi Arabia. AU - Kader,Abdulrahman A, AU - Angamuthu,Kumar, PY - 2005/6/29/pubmed PY - 2007/10/3/medline PY - 2005/6/29/entrez SP - 956 EP - 9 JF - Saudi medical journal JO - Saudi Med J VL - 26 IS - 6 N2 - OBJECTIVE: To evaluate the prevalence and antimicrobial susceptibility of extended spectrum beta-lactamase (ESBL) producing gram-negative organisms isolated from patients with urinary tract infection (UTI). METHODS: We carried out this study at Almana General Hospital, Eastern Province, Kingdom of Saudi Arabia, during the period August 2003 to October 2004. We studied urinary isolates of Escherichia coli (E. coli), Klebsiella pneumoniae (K. pneumoniae), Enterobacter spp and Pseudomonas aeruginosa (P. aeruginosa) for ESBL production and antimicrobial susceptibility. RESULTS: We studied a total of 2302 urinary gram-negative isolates for the presence of ceftazidime resistance and ESBL. The isolates included E. coli (1238), K. pneumoniae (522), Enterobacter spp (138) and P. aeruginosa (404). Of the 2302 isolates, 232 (10%) were ceftazidime resistant and 204 (8.9%) were ESBL producers. We detected ESBL in 119 (9.6%) E. coli, 59 (11.3%) K. pneumoniae, 14 (10.14%) Enterobacter species and 12 (2.97%) P. aeruginosa isolates. The ESBL-producing strains were most commonly isolated from patients with indwelling Foley s catheter [131 (64.2%)] and those in the long-term care ward [90 (44.2%)]. Only 26 (12.7%) ESBL-producing isolates were from outpatients. More than 89% of the ESBL producers were susceptible to imipenem and meropenem. Amikacin and piperacillin/tazobactam were active against 68% and 45% of the isolates. Susceptibility to gentamicin and ciprofloxacin was 22.5% and 14%. The least active antibiotic was cefepime (11.8%). CONCLUSION: This study shows the presence of ESBL producers in uropathogens from both inpatients and outpatients and demonstrates their high resistance to various classes of antimicrobial agents. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/15983682/Extended_spectrum_beta_lactamases_in_urinary_isolates_of_Escherichia_coli_Klebsiella_pneumoniae_and_other_gram_negative_bacteria_in_a_hospital_in_Eastern_Province_Saudi_Arabia_ L2 - http://www.diseaseinfosearch.org/result/4006 DB - PRIME DP - Unbound Medicine ER -