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Genetics and environmental risk factors associated with asthma in schoolchildren.
Eur Ann Allergy Clin Immunol. 2005 May; 37(5):163-8.EA

Abstract

OBJECTIVES

The objective of this study was to investigate the genetic and environmental risk factors associated with asthma among Qatari school children aged 6-12 years.

DESIGN

A cross-sectional study was performed. The International study of asthma and allergies in childhood (ISAAC) and some additional questionnaires were used to collect the data of the school children between Feb 2003 and Feb 2004.

SETTING

Government primary schools in the State of Qatar.

SUBJECTS

A multistage sampling design was used and a representative sample of 3500 children were targeted for this study. Of these, 3204 parents (91.6%) of the children agreed to participate in this study.

RESULTS

Of the total study sample 3204 school children living in urban and semi urban areas, 51.9% were boys and 48.1% girls. Their mean age was 8.92 +/- 1.89. The population sample had a high prevalence rate of asthma (19.8%) and allergic rhinitis 30.3%. The frequency of asthma, allergic rhinitis and eczema among parents reflected the same pattern as that seen in the children. Environmental risk factors associated with asthma were pets at home, allergic to certain food or medicine, smoking history among parents or elder siblings (p<0.0001). A stepwise logistic regression analysis results showed that allergic to food and medicine, history of asthma in father, mother, siblings and asthma in second degree relatives and smoking habit of father were significant predictors for asthma after adjusting age and sex and other confounding covariates in the model.

CONCLUSION

The present study revealed that the family history of asthma contributed more to childhood asthma than indoor and outdoor environmental factors. Boys were found more asthmatic than girls. The results of this study support the hypothesis that asthma is a multi-factorial disease related to both familial and environmental influences.

Authors+Show Affiliations

Department of Medical Statistics and Epidemiology, Hamad Medical Corporation and Hamad General Hospital, PO Box 3050, Doha, State of Qatar. abener@hmc.org.qaNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15984314

Citation

Bener, Abdulbari, et al. "Genetics and Environmental Risk Factors Associated With Asthma in Schoolchildren." European Annals of Allergy and Clinical Immunology, vol. 37, no. 5, 2005, pp. 163-8.
Bener A, Janahi IA, Sabbah A. Genetics and environmental risk factors associated with asthma in schoolchildren. Eur Ann Allergy Clin Immunol. 2005;37(5):163-8.
Bener, A., Janahi, I. A., & Sabbah, A. (2005). Genetics and environmental risk factors associated with asthma in schoolchildren. European Annals of Allergy and Clinical Immunology, 37(5), 163-8.
Bener A, Janahi IA, Sabbah A. Genetics and Environmental Risk Factors Associated With Asthma in Schoolchildren. Eur Ann Allergy Clin Immunol. 2005;37(5):163-8. PubMed PMID: 15984314.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetics and environmental risk factors associated with asthma in schoolchildren. AU - Bener,Abdulbari, AU - Janahi,Ibrahim A, AU - Sabbah,Alfred, PY - 2005/6/30/pubmed PY - 2005/8/9/medline PY - 2005/6/30/entrez SP - 163 EP - 8 JF - European annals of allergy and clinical immunology JO - Eur Ann Allergy Clin Immunol VL - 37 IS - 5 N2 - OBJECTIVES: The objective of this study was to investigate the genetic and environmental risk factors associated with asthma among Qatari school children aged 6-12 years. DESIGN: A cross-sectional study was performed. The International study of asthma and allergies in childhood (ISAAC) and some additional questionnaires were used to collect the data of the school children between Feb 2003 and Feb 2004. SETTING: Government primary schools in the State of Qatar. SUBJECTS: A multistage sampling design was used and a representative sample of 3500 children were targeted for this study. Of these, 3204 parents (91.6%) of the children agreed to participate in this study. RESULTS: Of the total study sample 3204 school children living in urban and semi urban areas, 51.9% were boys and 48.1% girls. Their mean age was 8.92 +/- 1.89. The population sample had a high prevalence rate of asthma (19.8%) and allergic rhinitis 30.3%. The frequency of asthma, allergic rhinitis and eczema among parents reflected the same pattern as that seen in the children. Environmental risk factors associated with asthma were pets at home, allergic to certain food or medicine, smoking history among parents or elder siblings (p<0.0001). A stepwise logistic regression analysis results showed that allergic to food and medicine, history of asthma in father, mother, siblings and asthma in second degree relatives and smoking habit of father were significant predictors for asthma after adjusting age and sex and other confounding covariates in the model. CONCLUSION: The present study revealed that the family history of asthma contributed more to childhood asthma than indoor and outdoor environmental factors. Boys were found more asthmatic than girls. The results of this study support the hypothesis that asthma is a multi-factorial disease related to both familial and environmental influences. SN - 1764-1489 UR - https://www.unboundmedicine.com/medline/citation/15984314/Genetics_and_environmental_risk_factors_associated_with_asthma_in_schoolchildren_ L2 - http://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -