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Relative elevation in baseline leukocyte count predicts first cerebral infarction.
Neurology. 2005 Jun 28; 64(12):2121-5.Neur

Abstract

BACKGROUND

Atherosclerosis is an inflammatory disease, and leukocyte levels are associated with future risk of ischemic cardiac disease.

OBJECTIVE

To investigate the hypothesis that relative elevations in leukocyte count in a stroke-free population predict future ischemic stroke (IS).

METHODS

A population-based prospective cohort study was performed in a multiethnic urban population. Stroke-free community participants were identified by random-digit dialing. Leukocyte levels were measured at enrollment, and participants were followed annually for IS, myocardial infarction (MI), and cause-specific mortality. Cox proportional hazards regression models were used to calculate hazard ratios (HRs) and 95% CIs for IS, MI, and vascular death after adjustment for medical, behavioral, and socioeconomic factors.

RESULTS

Among 3,103 stroke-free community participants (mean age 69.2 +/- 10.3 years) with baseline leukocyte levels measured, median follow-up was 5.2 years. After adjusting for stroke risk factors, each SD in leukocyte count (1.8 x 10(9) cells/L) was associated with an increased risk of IS (HR 1.22, 95% CI 1.05 to 1.42), and IS, MI, or vascular death (HR 1.13, 95% CI 1.02 to 1.26). Compared with those in the lowest quartile of leukocyte count, those in the highest had an increased risk of IS (adjusted HR 1.75, 95% CI 1.08 to 2.82). The effect on atherosclerotic and cardioembolic stroke was greater than in other stroke subtypes.

CONCLUSION

Relative elevations in leukocyte count are independently associated with an increased risk of future ischemic stroke and other cardiovascular events.

Authors+Show Affiliations

Department of Neurology, Columbia University College of Physicians and Surgeons, Joseph Mailman School of Public Health, New York, NY, USA. mse13@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15985584

Citation

Elkind, M S V., et al. "Relative Elevation in Baseline Leukocyte Count Predicts First Cerebral Infarction." Neurology, vol. 64, no. 12, 2005, pp. 2121-5.
Elkind MS, Sciacca RR, Boden-Albala B, et al. Relative elevation in baseline leukocyte count predicts first cerebral infarction. Neurology. 2005;64(12):2121-5.
Elkind, M. S., Sciacca, R. R., Boden-Albala, B., Rundek, T., Paik, M. C., & Sacco, R. L. (2005). Relative elevation in baseline leukocyte count predicts first cerebral infarction. Neurology, 64(12), 2121-5.
Elkind MS, et al. Relative Elevation in Baseline Leukocyte Count Predicts First Cerebral Infarction. Neurology. 2005 Jun 28;64(12):2121-5. PubMed PMID: 15985584.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relative elevation in baseline leukocyte count predicts first cerebral infarction. AU - Elkind,M S V, AU - Sciacca,R R, AU - Boden-Albala,B, AU - Rundek,T, AU - Paik,M C, AU - Sacco,R L, PY - 2005/6/30/pubmed PY - 2006/1/27/medline PY - 2005/6/30/entrez SP - 2121 EP - 5 JF - Neurology JO - Neurology VL - 64 IS - 12 N2 - BACKGROUND: Atherosclerosis is an inflammatory disease, and leukocyte levels are associated with future risk of ischemic cardiac disease. OBJECTIVE: To investigate the hypothesis that relative elevations in leukocyte count in a stroke-free population predict future ischemic stroke (IS). METHODS: A population-based prospective cohort study was performed in a multiethnic urban population. Stroke-free community participants were identified by random-digit dialing. Leukocyte levels were measured at enrollment, and participants were followed annually for IS, myocardial infarction (MI), and cause-specific mortality. Cox proportional hazards regression models were used to calculate hazard ratios (HRs) and 95% CIs for IS, MI, and vascular death after adjustment for medical, behavioral, and socioeconomic factors. RESULTS: Among 3,103 stroke-free community participants (mean age 69.2 +/- 10.3 years) with baseline leukocyte levels measured, median follow-up was 5.2 years. After adjusting for stroke risk factors, each SD in leukocyte count (1.8 x 10(9) cells/L) was associated with an increased risk of IS (HR 1.22, 95% CI 1.05 to 1.42), and IS, MI, or vascular death (HR 1.13, 95% CI 1.02 to 1.26). Compared with those in the lowest quartile of leukocyte count, those in the highest had an increased risk of IS (adjusted HR 1.75, 95% CI 1.08 to 2.82). The effect on atherosclerotic and cardioembolic stroke was greater than in other stroke subtypes. CONCLUSION: Relative elevations in leukocyte count are independently associated with an increased risk of future ischemic stroke and other cardiovascular events. SN - 1526-632X UR - https://www.unboundmedicine.com/medline/citation/15985584/Relative_elevation_in_baseline_leukocyte_count_predicts_first_cerebral_infarction_ L2 - http://www.neurology.org/cgi/pmidlookup?view=long&pmid=15985584 DB - PRIME DP - Unbound Medicine ER -