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Pancreatic juice cytology in IPMN of the pancreas.
Pancreatology. 2005; 5(4-5):416-21; discussion 421.P

Abstract

BACKGROUND

Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas is a disease ranging from adenoma to borderline (with moderate dysplasia) and further to carcinoma (noninvasive and invasive) and surgical strategy is different by the grades of dysplasia.

METHODS

Preoperative pancreatic juice cytology in IPMN was reviewed in 71 patients with IPMN who underwent surgical resection.

RESULTS

The IPMN was adenoma in 48 patients, borderline in 13 and carcinoma (invasive) in 10. The sensitivity of pancreatic juice cytology in malignant IPMN was 40% (4/10). In 4 patients with the 48 IPM adenomas, diagnosis of pancreatic juice cytology was class IV or V. One of the 4 cases was considered to be an overdiagnosis of cytology, but the other 3 cases were considered to be a consequence of accompanying carcinoma in situ (or PanIN-3) (2 patients) or invasive ductal adenocarcinoma (1 patient) apart from IPMN. Sensitivity of pancreatic juice cytology was higher in IPMN of the main duct type with mucin hypersecretion and with mural nodules.

CONCLUSIONS

These findings suggest that pancreatic juice cytology in IPMN is useful especially in the main duct type with mucin hypersecretion and mural nodules. When the diagnosis of pancreatic juice cytology is malignant in otherwise benign-looking IPMNs, coexistence of pancreatic carcinoma should be suspected.

Authors+Show Affiliations

Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. yamaguch@surg1.med.kyush-n.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15985766

Citation

Yamaguchi, Koji, et al. "Pancreatic Juice Cytology in IPMN of the Pancreas." Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.], vol. 5, no. 4-5, 2005, pp. 416-21; discussion 421.
Yamaguchi K, Nakamura M, Shirahane K, et al. Pancreatic juice cytology in IPMN of the pancreas. Pancreatology. 2005;5(4-5):416-21; discussion 421.
Yamaguchi, K., Nakamura, M., Shirahane, K., Kawamoto, M., Konomi, H., Ohta, M., & Tanaka, M. (2005). Pancreatic juice cytology in IPMN of the pancreas. Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.], 5(4-5), 416-21; discussion 421.
Yamaguchi K, et al. Pancreatic Juice Cytology in IPMN of the Pancreas. Pancreatology. 2005;5(4-5):416-21; discussion 421. PubMed PMID: 15985766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic juice cytology in IPMN of the pancreas. AU - Yamaguchi,Koji, AU - Nakamura,Masafumi, AU - Shirahane,Kengo, AU - Kawamoto,Masahiko, AU - Konomi,Hiroyuki, AU - Ohta,Masayukii, AU - Tanaka,Masao, Y1 - 2005/06/28/ PY - 2003/12/16/received PY - 2004/11/02/accepted PY - 2005/6/30/pubmed PY - 2005/9/30/medline PY - 2005/6/30/entrez SP - 416-21; discussion 421 JF - Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] JO - Pancreatology VL - 5 IS - 4-5 N2 - BACKGROUND: Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas is a disease ranging from adenoma to borderline (with moderate dysplasia) and further to carcinoma (noninvasive and invasive) and surgical strategy is different by the grades of dysplasia. METHODS: Preoperative pancreatic juice cytology in IPMN was reviewed in 71 patients with IPMN who underwent surgical resection. RESULTS: The IPMN was adenoma in 48 patients, borderline in 13 and carcinoma (invasive) in 10. The sensitivity of pancreatic juice cytology in malignant IPMN was 40% (4/10). In 4 patients with the 48 IPM adenomas, diagnosis of pancreatic juice cytology was class IV or V. One of the 4 cases was considered to be an overdiagnosis of cytology, but the other 3 cases were considered to be a consequence of accompanying carcinoma in situ (or PanIN-3) (2 patients) or invasive ductal adenocarcinoma (1 patient) apart from IPMN. Sensitivity of pancreatic juice cytology was higher in IPMN of the main duct type with mucin hypersecretion and with mural nodules. CONCLUSIONS: These findings suggest that pancreatic juice cytology in IPMN is useful especially in the main duct type with mucin hypersecretion and mural nodules. When the diagnosis of pancreatic juice cytology is malignant in otherwise benign-looking IPMNs, coexistence of pancreatic carcinoma should be suspected. SN - 1424-3903 UR - https://www.unboundmedicine.com/medline/citation/15985766/Pancreatic_juice_cytology_in_IPMN_of_the_pancreas_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1424-3903(05)80016-X DB - PRIME DP - Unbound Medicine ER -