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Alcaligenes xylosoxidans bacteremia: clinical features and microbiological characteristics of isolates.
J Microbiol Immunol Infect. 2005 Jun; 38(3):194-9.JM

Abstract

Bacteremia caused by Alcaligenes xylosoxidans is rare. Between 1999 and 2002, 12 cases of bacteremia caused by A. xylosoxidans were diagnosed at a tertiary referral center in central Taiwan. The clinical features of these patients and the antimicrobial susceptibilities and pulsed-field gel electrophoresis (PFGE) pattern of their blood isolates were studied. All infections were acquired nosocomially. All of the adult patients had underlying diseases, and 10 (83%) had undergone an invasive procedure. The clinical syndrome included primary bacteremia in 7 patients (58%), and catheter-associated bacteremia, surgical wound infection, pneumonia, urinary tract infection, and empyema in 1 each. Polymicrobial bacteremia was found in 1 patient. The case-fatality rate was 17% (2/12). All isolates were susceptible to piperacillin and ceftazidime and resistant to aminoglycoside, ciprofloxacin and cefepime. Susceptibility to imipenem (67%), ampicillin-sulbactam (75%) and trimethoprim-sulfamethoxazole (92%) was variable. Genetic fingerprints obtained by PFGE showed identical pattern in the isolates from 2 neonates, indicating the epidemiologic relatedness of these infections. We conclude that A. xylosoxidans isolates are multi-resistant and A. xylosoxidans bacteremia should be considered as a possible etiology of infection after invasive procedures in patients with underlying diseases. Strict infection control is needed to prevent this infection.

Authors+Show Affiliations

Division of Infectious Diseases, Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15986070

Citation

Tsay, Ren-Wen, et al. "Alcaligenes Xylosoxidans Bacteremia: Clinical Features and Microbiological Characteristics of Isolates." Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, vol. 38, no. 3, 2005, pp. 194-9.
Tsay RW, Lin LC, Chiou CS, et al. Alcaligenes xylosoxidans bacteremia: clinical features and microbiological characteristics of isolates. J Microbiol Immunol Infect. 2005;38(3):194-9.
Tsay, R. W., Lin, L. C., Chiou, C. S., Liao, J. C., Chen, C. H., Liu, C. E., & Young, T. G. (2005). Alcaligenes xylosoxidans bacteremia: clinical features and microbiological characteristics of isolates. Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi, 38(3), 194-9.
Tsay RW, et al. Alcaligenes Xylosoxidans Bacteremia: Clinical Features and Microbiological Characteristics of Isolates. J Microbiol Immunol Infect. 2005;38(3):194-9. PubMed PMID: 15986070.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcaligenes xylosoxidans bacteremia: clinical features and microbiological characteristics of isolates. AU - Tsay,Ren-Wen, AU - Lin,Li-Chen, AU - Chiou,Chien-Shun, AU - Liao,Jui-Cheng, AU - Chen,Chang-Hua, AU - Liu,Chun-Eng, AU - Young,Tzuu-Guang, PY - 2005/6/30/pubmed PY - 2005/8/27/medline PY - 2005/6/30/entrez SP - 194 EP - 9 JF - Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi JO - J Microbiol Immunol Infect VL - 38 IS - 3 N2 - Bacteremia caused by Alcaligenes xylosoxidans is rare. Between 1999 and 2002, 12 cases of bacteremia caused by A. xylosoxidans were diagnosed at a tertiary referral center in central Taiwan. The clinical features of these patients and the antimicrobial susceptibilities and pulsed-field gel electrophoresis (PFGE) pattern of their blood isolates were studied. All infections were acquired nosocomially. All of the adult patients had underlying diseases, and 10 (83%) had undergone an invasive procedure. The clinical syndrome included primary bacteremia in 7 patients (58%), and catheter-associated bacteremia, surgical wound infection, pneumonia, urinary tract infection, and empyema in 1 each. Polymicrobial bacteremia was found in 1 patient. The case-fatality rate was 17% (2/12). All isolates were susceptible to piperacillin and ceftazidime and resistant to aminoglycoside, ciprofloxacin and cefepime. Susceptibility to imipenem (67%), ampicillin-sulbactam (75%) and trimethoprim-sulfamethoxazole (92%) was variable. Genetic fingerprints obtained by PFGE showed identical pattern in the isolates from 2 neonates, indicating the epidemiologic relatedness of these infections. We conclude that A. xylosoxidans isolates are multi-resistant and A. xylosoxidans bacteremia should be considered as a possible etiology of infection after invasive procedures in patients with underlying diseases. Strict infection control is needed to prevent this infection. SN - 1684-1182 UR - https://www.unboundmedicine.com/medline/citation/15986070/Alcaligenes_xylosoxidans_bacteremia:_clinical_features_and_microbiological_characteristics_of_isolates_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -