Tags

Type your tag names separated by a space and hit enter

C-peptide, IGF-I, sex-steroid hormones and adiposity: a cross-sectional study in healthy women within the European Prospective Investigation into Cancer and Nutrition (EPIC).
Cancer Causes Control. 2005 Jun; 16(5):561-72.CC

Abstract

OBJECTIVES

The risk of some cancers is positively associated with body weight, which may influence circulating levels of sex-steroid hormones, insulin and IGF-I. Interrelationships between these hormones and the associations with adiposity were evaluated in healthy women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC).

METHODS

A cross-sectional analysis was performed on anthropometric and hormonal data from 743 pre- and 1217 postmenopausal women. Body mass index (BMI) and waist circumference were used as indicators of adiposity. C-peptide, Insulin Growth Factor (IGF)-I, Insulin Growth Factor binding protein (IGFBP)-3, androgens, estrogens and sex hormone binding globulin (SHBG) were measured by immunoassays; free sex steroid concentrations were calculated.

RESULTS

BMI and waist circumference were positively correlated with estrogens in postmenopausal women and with C-peptide, free testosterone and inversely with SHBG in all women. C-peptide and IGF-I were inversely correlated with SHBG, and positively with free sex steroids in postmenopausal women. IGF-I was positively associated with postmenopausal estrogens and androgen concentrations in all women.

CONCLUSIONS

Sex-steroid concentrations appear to be regulated along several axes. Adiposity correlated directly with estrogens in postmenopausal women and with insulin, resulting in lower SHBG and increased levels of free sex steroids. Independent of adiposity and insulin, IGF-I was associated with decreased SHBG levels, and increased concentrations of androgens and postmenopausal estrogens.

Authors+Show Affiliations

International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon CEDEX 08, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15986111

Citation

Bezemer, Irene D., et al. "C-peptide, IGF-I, Sex-steroid Hormones and Adiposity: a Cross-sectional Study in Healthy Women Within the European Prospective Investigation Into Cancer and Nutrition (EPIC)." Cancer Causes & Control : CCC, vol. 16, no. 5, 2005, pp. 561-72.
Bezemer ID, Rinaldi S, Dossus L, et al. C-peptide, IGF-I, sex-steroid hormones and adiposity: a cross-sectional study in healthy women within the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes Control. 2005;16(5):561-72.
Bezemer, I. D., Rinaldi, S., Dossus, L., Gils, C. H., Peeters, P. H., Noord, P. A., Bueno-de-Mesquita, H. B., Johnsen, S. P., Overvad, K., Olsen, A., Tjønneland, A., Boeing, H., Lahmann, P. H., Linseisen, J., Nagel, G., Allen, N., Roddam, A., Bingham, S., Khaw, K. T., ... Kaaks, R. (2005). C-peptide, IGF-I, sex-steroid hormones and adiposity: a cross-sectional study in healthy women within the European Prospective Investigation into Cancer and Nutrition (EPIC). Cancer Causes & Control : CCC, 16(5), 561-72.
Bezemer ID, et al. C-peptide, IGF-I, Sex-steroid Hormones and Adiposity: a Cross-sectional Study in Healthy Women Within the European Prospective Investigation Into Cancer and Nutrition (EPIC). Cancer Causes Control. 2005;16(5):561-72. PubMed PMID: 15986111.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C-peptide, IGF-I, sex-steroid hormones and adiposity: a cross-sectional study in healthy women within the European Prospective Investigation into Cancer and Nutrition (EPIC). AU - Bezemer,Irene D, AU - Rinaldi,Sabina, AU - Dossus,Laure, AU - Gils,Carla H van, AU - Peeters,Petra H M, AU - Noord,Paulus A H van, AU - Bueno-de-Mesquita,H Bas, AU - Johnsen,Soren Paaske, AU - Overvad,Kim, AU - Olsen,Anja, AU - Tjønneland,Anne, AU - Boeing,Heiner, AU - Lahmann,Petra H, AU - Linseisen,Jakob, AU - Nagel,Gabriele, AU - Allen,Naomi, AU - Roddam,Andrew, AU - Bingham,Sheila, AU - Khaw,Kay-Tee, AU - Kesse,Emmanuelle, AU - Téhard,Bertrand, AU - Clavel-Chapelon,Françoise, AU - Agudo,Antonio, AU - Ardanaz,Eva, AU - Quiros,J R, AU - Amiano,Pilar, AU - Martínez-Garcia,C, AU - Tormo,M J, AU - Pala,Valeria, AU - Panico,Salvatore, AU - Vineis,Paolo, AU - Palli,Domenico, AU - Tumino,Rosario, AU - Trichopoulou,Antonia, AU - Baibas,N, AU - Zilis,D, AU - Hémon,Bertrand, AU - Norat,Teresa, AU - Riboli,Elio, AU - Kaaks,Rudolf, PY - 2004/09/16/received PY - 2004/12/10/accepted PY - 2005/6/30/pubmed PY - 2005/12/15/medline PY - 2005/6/30/entrez SP - 561 EP - 72 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 16 IS - 5 N2 - OBJECTIVES: The risk of some cancers is positively associated with body weight, which may influence circulating levels of sex-steroid hormones, insulin and IGF-I. Interrelationships between these hormones and the associations with adiposity were evaluated in healthy women participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). METHODS: A cross-sectional analysis was performed on anthropometric and hormonal data from 743 pre- and 1217 postmenopausal women. Body mass index (BMI) and waist circumference were used as indicators of adiposity. C-peptide, Insulin Growth Factor (IGF)-I, Insulin Growth Factor binding protein (IGFBP)-3, androgens, estrogens and sex hormone binding globulin (SHBG) were measured by immunoassays; free sex steroid concentrations were calculated. RESULTS: BMI and waist circumference were positively correlated with estrogens in postmenopausal women and with C-peptide, free testosterone and inversely with SHBG in all women. C-peptide and IGF-I were inversely correlated with SHBG, and positively with free sex steroids in postmenopausal women. IGF-I was positively associated with postmenopausal estrogens and androgen concentrations in all women. CONCLUSIONS: Sex-steroid concentrations appear to be regulated along several axes. Adiposity correlated directly with estrogens in postmenopausal women and with insulin, resulting in lower SHBG and increased levels of free sex steroids. Independent of adiposity and insulin, IGF-I was associated with decreased SHBG levels, and increased concentrations of androgens and postmenopausal estrogens. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/15986111/C_peptide_IGF_I_sex_steroid_hormones_and_adiposity:_a_cross_sectional_study_in_healthy_women_within_the_European_Prospective_Investigation_into_Cancer_and_Nutrition__EPIC__ L2 - https://doi.org/10.1007/s10552-004-7472-9 DB - PRIME DP - Unbound Medicine ER -