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Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations.
Arthritis Rheum. 2005 Jul; 52(7):1993-8.AR

Abstract

OBJECTIVE

A single-nucleotide polymorphism in the PTPN22 gene encoding the lymphoid protein tyrosine phosphatase (Lyp) has recently been identified as a functional variant associated with susceptibility to rheumatoid arthritis (RA), type 1 diabetes, and systemic lupus erythematosus. To determine whether association of this variant (PTPN22 1858T) with RA is reproducible and is also observed in another autoimmune condition, Crohn's disease, we investigated the association between the PTPN22 1858T allele and RA and Crohn's disease in a Canadian population.

METHODS

Two RA case-control cohorts representing a total of 1,234 patients and 791 healthy controls as well as a cohort of 455 patients with Crohn's disease and 190 controls were genotyped for the PTPN22 C1858T polymorphism, and genotype frequencies were compared between patients and controls.

RESULTS

Significant association of the PTPN22 1858T allele with RA was detected in both the Toronto-based RA cohort (P = 1.6 x 10(-6), odds ratio [OR] 1.8) and the Halifax-based RA cohort (P = 9.4 x 10(-4), OR 1.94). Association of the risk allele with RA was not affected by sex, age at disease onset, or the presence of either rheumatoid factor or rheumatoid nodules. No association between the PTPN22 risk allele and Crohn's disease was detected.

CONCLUSION

These observations confirm the association of RA susceptibility with the PTPN22 1858T allele. However, the data also reveal a lack of association between this variant and Crohn's disease, suggesting that the PTPN22 1858T allele is a risk allele for multiple, but not all, autoimmune diseases.

Authors+Show Affiliations

Ellipsis Biotherapeutics Corporation, Toronto, Ontario, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15986374

Citation

van Oene, Mark, et al. "Association of the Lymphoid Tyrosine Phosphatase R620W Variant With Rheumatoid Arthritis, but Not Crohn's Disease, in Canadian Populations." Arthritis and Rheumatism, vol. 52, no. 7, 2005, pp. 1993-8.
van Oene M, Wintle RF, Liu X, et al. Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations. Arthritis Rheum. 2005;52(7):1993-8.
van Oene, M., Wintle, R. F., Liu, X., Yazdanpanah, M., Gu, X., Newman, B., Kwan, A., Johnson, B., Owen, J., Greer, W., Mosher, D., Maksymowych, W., Keystone, E., Rubin, L. A., Amos, C. I., & Siminovitch, K. A. (2005). Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations. Arthritis and Rheumatism, 52(7), 1993-8.
van Oene M, et al. Association of the Lymphoid Tyrosine Phosphatase R620W Variant With Rheumatoid Arthritis, but Not Crohn's Disease, in Canadian Populations. Arthritis Rheum. 2005;52(7):1993-8. PubMed PMID: 15986374.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of the lymphoid tyrosine phosphatase R620W variant with rheumatoid arthritis, but not Crohn's disease, in Canadian populations. AU - van Oene,Mark, AU - Wintle,Richard F, AU - Liu,Xiangdong, AU - Yazdanpanah,Mehrdad, AU - Gu,Xiangjun, AU - Newman,Bill, AU - Kwan,Albert, AU - Johnson,Benjamin, AU - Owen,Julie, AU - Greer,Wenda, AU - Mosher,Dianne, AU - Maksymowych,Walter, AU - Keystone,Ed, AU - Rubin,Laurence A, AU - Amos,Christopher I, AU - Siminovitch,Katherine A, PY - 2005/6/30/pubmed PY - 2005/8/17/medline PY - 2005/6/30/entrez SP - 1993 EP - 8 JF - Arthritis and rheumatism JO - Arthritis Rheum VL - 52 IS - 7 N2 - OBJECTIVE: A single-nucleotide polymorphism in the PTPN22 gene encoding the lymphoid protein tyrosine phosphatase (Lyp) has recently been identified as a functional variant associated with susceptibility to rheumatoid arthritis (RA), type 1 diabetes, and systemic lupus erythematosus. To determine whether association of this variant (PTPN22 1858T) with RA is reproducible and is also observed in another autoimmune condition, Crohn's disease, we investigated the association between the PTPN22 1858T allele and RA and Crohn's disease in a Canadian population. METHODS: Two RA case-control cohorts representing a total of 1,234 patients and 791 healthy controls as well as a cohort of 455 patients with Crohn's disease and 190 controls were genotyped for the PTPN22 C1858T polymorphism, and genotype frequencies were compared between patients and controls. RESULTS: Significant association of the PTPN22 1858T allele with RA was detected in both the Toronto-based RA cohort (P = 1.6 x 10(-6), odds ratio [OR] 1.8) and the Halifax-based RA cohort (P = 9.4 x 10(-4), OR 1.94). Association of the risk allele with RA was not affected by sex, age at disease onset, or the presence of either rheumatoid factor or rheumatoid nodules. No association between the PTPN22 risk allele and Crohn's disease was detected. CONCLUSION: These observations confirm the association of RA susceptibility with the PTPN22 1858T allele. However, the data also reveal a lack of association between this variant and Crohn's disease, suggesting that the PTPN22 1858T allele is a risk allele for multiple, but not all, autoimmune diseases. SN - 0004-3591 UR - https://www.unboundmedicine.com/medline/citation/15986374/Association_of_the_lymphoid_tyrosine_phosphatase_R620W_variant_with_rheumatoid_arthritis_but_not_Crohn's_disease_in_Canadian_populations_ L2 - https://doi.org/10.1002/art.21123 DB - PRIME DP - Unbound Medicine ER -