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Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice.
Respir Res. 2005 Jun 29; 6:66.RR

Abstract

Here we investigate the effects of the green tea extract in an animal model of acute inflammation, carrageenan-induced pleurisy. We report here that green tea extract (given at 25 mg/kg i.p. bolus 1 h prior to carrageenan), exerts potent anti-inflammatory effects in an animal model of acute inflammation in vivo. Injection of carrageenan (2%) into the pleural cavity of mice elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity that contained many neutrophils (PMNs), an infiltration of PMNs in lung tissues and increased production of nitrite/nitrate, tumour necrosis factor alpha. All parameters of inflammation were attenuated by green tea extract treatment. Furthermore, carrageenan induced an up-regulation of the adhesion molecule ICAM-1, as well as nitrotyrosine and poly (ADP-ribose) synthetase (PARS) formation, as determined by immunohistochemical analysis of lung tissues. Staining for the ICAM-1, nitrotyrosine, and PARS was reduced by green tea extract. Our results clearly demonstrate that treatment with green tea extract exerts a protective effect and offers a novel therapeutic approach for the management of lung injury.

Authors+Show Affiliations

Department of Clinical and Experimental Medicine and Pharmacology, Torre Biologica, Policlinico Universitario, Messina, Italy. salvator@unime.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15987519

Citation

Di Paola, Rosanna, et al. "Green Tea Polyphenol Extract Attenuates Lung Injury in Experimental Model of Carrageenan-induced Pleurisy in Mice." Respiratory Research, vol. 6, 2005, p. 66.
Di Paola R, Mazzon E, Muià C, et al. Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice. Respir Res. 2005;6:66.
Di Paola, R., Mazzon, E., Muià, C., Genovese, T., Menegazzi, M., Zaffini, R., Suzuki, H., & Cuzzocrea, S. (2005). Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice. Respiratory Research, 6, 66.
Di Paola R, et al. Green Tea Polyphenol Extract Attenuates Lung Injury in Experimental Model of Carrageenan-induced Pleurisy in Mice. Respir Res. 2005 Jun 29;6:66. PubMed PMID: 15987519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice. AU - Di Paola,Rosanna, AU - Mazzon,Emanuela, AU - Muià,Carmelo, AU - Genovese,Tiziana, AU - Menegazzi,Marta, AU - Zaffini,Raffaela, AU - Suzuki,Hisanory, AU - Cuzzocrea,Salvatore, Y1 - 2005/06/29/ PY - 2005/04/21/received PY - 2005/06/29/accepted PY - 2005/7/1/pubmed PY - 2006/3/18/medline PY - 2005/7/1/entrez SP - 66 EP - 66 JF - Respiratory research JO - Respir Res VL - 6 N2 - Here we investigate the effects of the green tea extract in an animal model of acute inflammation, carrageenan-induced pleurisy. We report here that green tea extract (given at 25 mg/kg i.p. bolus 1 h prior to carrageenan), exerts potent anti-inflammatory effects in an animal model of acute inflammation in vivo. Injection of carrageenan (2%) into the pleural cavity of mice elicited an acute inflammatory response characterized by fluid accumulation in the pleural cavity that contained many neutrophils (PMNs), an infiltration of PMNs in lung tissues and increased production of nitrite/nitrate, tumour necrosis factor alpha. All parameters of inflammation were attenuated by green tea extract treatment. Furthermore, carrageenan induced an up-regulation of the adhesion molecule ICAM-1, as well as nitrotyrosine and poly (ADP-ribose) synthetase (PARS) formation, as determined by immunohistochemical analysis of lung tissues. Staining for the ICAM-1, nitrotyrosine, and PARS was reduced by green tea extract. Our results clearly demonstrate that treatment with green tea extract exerts a protective effect and offers a novel therapeutic approach for the management of lung injury. SN - 1465-993X UR - https://www.unboundmedicine.com/medline/citation/15987519/Green_tea_polyphenol_extract_attenuates_lung_injury_in_experimental_model_of_carrageenan_induced_pleurisy_in_mice_ L2 - https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-6-66 DB - PRIME DP - Unbound Medicine ER -