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Clinical efficacy of racemic albuterol versus levalbuterol for the treatment of acute pediatric asthma.
Ann Emerg Med 2005; 46(1):29-36AE

Abstract

STUDY OBJECTIVE

An efficacy treatment study is conducted comparing levalbuterol to racemic albuterol for acute pediatric asthma in the emergency department (ED).

METHODS

This was a prospective, double-blind, randomized, controlled study involving 129 children (2 to 14 years), presenting to a pediatric ED with an acute moderate or severe asthma exacerbation. Children were treated using a standard ED asthma pathway. Primary outcomes were changes from baseline in clinical asthma score and the percentage of predicted forced expiratory volume in 1 second after the first, third, and fifth treatment. Secondary outcomes included number of treatments, length of ED care, rate of hospitalization, and changes in pulse rate, respiratory rate, and oxygen saturation. Occurrence of adverse events was recorded.

RESULTS

Sixty-four children in the racemic albuterol and 65 children in the levalbuterol group completed the study. There were no differences between groups in primary outcomes, secondary outcomes, or adverse events.

CONCLUSION

There was no difference in clinical improvement in children with acute moderate to severe asthma exacerbations treated with either racemic albuterol or levalbuterol.

Authors+Show Affiliations

Department of Pediatric Emergency Medicine, Children's Hospital of The King's Daughters, Eastern Virginia Medical School, Norfolk, VA 23507, USA. fqureshi@chkd.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15988423

Citation

Qureshi, Faiqa, et al. "Clinical Efficacy of Racemic Albuterol Versus Levalbuterol for the Treatment of Acute Pediatric Asthma." Annals of Emergency Medicine, vol. 46, no. 1, 2005, pp. 29-36.
Qureshi F, Zaritsky A, Welch C, et al. Clinical efficacy of racemic albuterol versus levalbuterol for the treatment of acute pediatric asthma. Ann Emerg Med. 2005;46(1):29-36.
Qureshi, F., Zaritsky, A., Welch, C., Meadows, T., & Burke, B. L. (2005). Clinical efficacy of racemic albuterol versus levalbuterol for the treatment of acute pediatric asthma. Annals of Emergency Medicine, 46(1), pp. 29-36.
Qureshi F, et al. Clinical Efficacy of Racemic Albuterol Versus Levalbuterol for the Treatment of Acute Pediatric Asthma. Ann Emerg Med. 2005;46(1):29-36. PubMed PMID: 15988423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical efficacy of racemic albuterol versus levalbuterol for the treatment of acute pediatric asthma. AU - Qureshi,Faiqa, AU - Zaritsky,Arno, AU - Welch,Camille, AU - Meadows,Teresa, AU - Burke,Bonnie L, PY - 2005/7/1/pubmed PY - 2006/1/31/medline PY - 2005/7/1/entrez SP - 29 EP - 36 JF - Annals of emergency medicine JO - Ann Emerg Med VL - 46 IS - 1 N2 - STUDY OBJECTIVE: An efficacy treatment study is conducted comparing levalbuterol to racemic albuterol for acute pediatric asthma in the emergency department (ED). METHODS: This was a prospective, double-blind, randomized, controlled study involving 129 children (2 to 14 years), presenting to a pediatric ED with an acute moderate or severe asthma exacerbation. Children were treated using a standard ED asthma pathway. Primary outcomes were changes from baseline in clinical asthma score and the percentage of predicted forced expiratory volume in 1 second after the first, third, and fifth treatment. Secondary outcomes included number of treatments, length of ED care, rate of hospitalization, and changes in pulse rate, respiratory rate, and oxygen saturation. Occurrence of adverse events was recorded. RESULTS: Sixty-four children in the racemic albuterol and 65 children in the levalbuterol group completed the study. There were no differences between groups in primary outcomes, secondary outcomes, or adverse events. CONCLUSION: There was no difference in clinical improvement in children with acute moderate to severe asthma exacerbations treated with either racemic albuterol or levalbuterol. SN - 1097-6760 UR - https://www.unboundmedicine.com/medline/citation/15988423/Clinical_efficacy_of_racemic_albuterol_versus_levalbuterol_for_the_treatment_of_acute_pediatric_asthma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0196064405001381 DB - PRIME DP - Unbound Medicine ER -