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Pravastatin does not affect insulin sensitivity and adipocytokines levels in healthy nondiabetic patients.
Metabolism. 2005 Jul; 54(7):947-51.M

Abstract

BACKGROUND

The effect of statins on insulin resistance is controversial and poorly studied in nondiabetic subjects. In addition, the effect of statins on leptin and adiponectin has never been studied.

METHODS

Forty healthy nondiabetic volunteers (22 men and 18 women) aged 28 to 72 were randomized either to placebo or pravastatin 40 mg daily for a 12-week period. Insulin resistance, assessed using the Quantitative Insulin Sensitivity Check Index (QUICKI), as well as serum leptin and adiponectin levels, was measured at baseline and at the end of therapy.

RESULTS

Pravastatin treatment decreased total cholesterol, low-density lipoprotein cholesterol, and triglycerides levels by 24%, 32%, and 14%, respectively (P < .05 for all), but did not affect glucose and insulin levels, the (QUICKI) index, and adiponectin and leptin levels. When stratification was performed according to QUICKI index or sex, no significant differences were observed in the prevalues and postvalues of leptin, adiponectin, or QUICKI index in the pravastatin group. Adiponectin, leptin, and QUICKI index were statistically higher in women than in men (P < .001 for both variables). Adiponectin was negatively correlated with body mass index (BMI; r = -0.39, P < .05) and positively correlated with the QUICKI index (r = 0.54, P < .001) and with high-density lipoprotein cholesterol (r = 0.50, P < .01). The relation between adiponectin and QUICKI index remained significant after adjustment for sex and BMI (P = .005 and P = .007, respectively). Leptin was only related to BMI (r = 0.57, P < .001) and to sex (P < .001) with no significant correlations with lipid parameters or QUICKI index. Both sex and BMI are independent predictors of leptin (P < .001 and P < .001).

CONCLUSION

A 12-week treatment with pravastatin 40 mg/d does not change the QUICKI index and leptin and adiponectin levels in healthy volunteers. In addition, our results emphasize the importance of sex and BMI in the determination of both adiponectin and leptin. Adiponectin was also related to QUICKI index, whereas this relation was not found with leptin.

Authors+Show Affiliations

Division of Endocrinology, Hôtel-Dieu de France Hospital, Beirut, Lebanon. mhcyared@terra.net.lbNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15988706

Citation

Gannagé-Yared, Marie-Hélène, et al. "Pravastatin Does Not Affect Insulin Sensitivity and Adipocytokines Levels in Healthy Nondiabetic Patients." Metabolism: Clinical and Experimental, vol. 54, no. 7, 2005, pp. 947-51.
Gannagé-Yared MH, Azar RR, Amm-Azar M, et al. Pravastatin does not affect insulin sensitivity and adipocytokines levels in healthy nondiabetic patients. Metab Clin Exp. 2005;54(7):947-51.
Gannagé-Yared, M. H., Azar, R. R., Amm-Azar, M., Khalifé, S., Germanos-Haddad, M., Neemtallah, R., & Halaby, G. (2005). Pravastatin does not affect insulin sensitivity and adipocytokines levels in healthy nondiabetic patients. Metabolism: Clinical and Experimental, 54(7), 947-51.
Gannagé-Yared MH, et al. Pravastatin Does Not Affect Insulin Sensitivity and Adipocytokines Levels in Healthy Nondiabetic Patients. Metab Clin Exp. 2005;54(7):947-51. PubMed PMID: 15988706.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pravastatin does not affect insulin sensitivity and adipocytokines levels in healthy nondiabetic patients. AU - Gannagé-Yared,Marie-Hélène, AU - Azar,Rabih R, AU - Amm-Azar,Mireille, AU - Khalifé,Simon, AU - Germanos-Haddad,Myrna, AU - Neemtallah,Ramy, AU - Halaby,Georges, PY - 2005/7/1/pubmed PY - 2005/8/24/medline PY - 2005/7/1/entrez SP - 947 EP - 51 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 54 IS - 7 N2 - BACKGROUND: The effect of statins on insulin resistance is controversial and poorly studied in nondiabetic subjects. In addition, the effect of statins on leptin and adiponectin has never been studied. METHODS: Forty healthy nondiabetic volunteers (22 men and 18 women) aged 28 to 72 were randomized either to placebo or pravastatin 40 mg daily for a 12-week period. Insulin resistance, assessed using the Quantitative Insulin Sensitivity Check Index (QUICKI), as well as serum leptin and adiponectin levels, was measured at baseline and at the end of therapy. RESULTS: Pravastatin treatment decreased total cholesterol, low-density lipoprotein cholesterol, and triglycerides levels by 24%, 32%, and 14%, respectively (P < .05 for all), but did not affect glucose and insulin levels, the (QUICKI) index, and adiponectin and leptin levels. When stratification was performed according to QUICKI index or sex, no significant differences were observed in the prevalues and postvalues of leptin, adiponectin, or QUICKI index in the pravastatin group. Adiponectin, leptin, and QUICKI index were statistically higher in women than in men (P < .001 for both variables). Adiponectin was negatively correlated with body mass index (BMI; r = -0.39, P < .05) and positively correlated with the QUICKI index (r = 0.54, P < .001) and with high-density lipoprotein cholesterol (r = 0.50, P < .01). The relation between adiponectin and QUICKI index remained significant after adjustment for sex and BMI (P = .005 and P = .007, respectively). Leptin was only related to BMI (r = 0.57, P < .001) and to sex (P < .001) with no significant correlations with lipid parameters or QUICKI index. Both sex and BMI are independent predictors of leptin (P < .001 and P < .001). CONCLUSION: A 12-week treatment with pravastatin 40 mg/d does not change the QUICKI index and leptin and adiponectin levels in healthy volunteers. In addition, our results emphasize the importance of sex and BMI in the determination of both adiponectin and leptin. Adiponectin was also related to QUICKI index, whereas this relation was not found with leptin. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/15988706/Pravastatin_does_not_affect_insulin_sensitivity_and_adipocytokines_levels_in_healthy_nondiabetic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026049505000983 DB - PRIME DP - Unbound Medicine ER -