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Supplementation with DHEA: effect on muscle size, strength, quality of life, and lipids.
J Womens Health (Larchmt). 2005 Jun; 14(5):391-400.JW

Abstract

OBJECTIVE

To evaluate the effects of combination estrogen/androgen therapy on muscle mass, strength and endurance, serum hormone and lipid profiles, and quality of life measures in postmenopausal women.

METHODS

Prospective, randomized, placebo-controlled pilot study at a tertiary care medical center. Fifty postmenopausal women were randomized to a 12-week course of (1) dehydroepiandrostenedione (DHEA) 50 mg daily, (2) conjugated equine estrogen (CEE) 0.625 mg daily, (3) DHEA 50 mg+CEE 0.625 mg daily, or (4) placebo. Main outcome measures of lower extremity muscle (calf) mass, functional muscle parameters, serum hormone and lipid levels, and quality of life (QOL) were obtained at baseline and after treatment. Statistical analysis compared percent change from baseline values and treatment differences among outcomes.

RESULTS

Significant increases in mean DHEA, DHEA sulfate (DHEA-S), testosterone, and androstenedione levels were noted with DHEA alone or combined DHEA/CEE treatments when compared with placebo. Compared with no hormone therapy, none of the supplemental hormone groups caused significant changes in muscle mass, muscle strength, muscle endurance, feelings of well-being, sleep, or sexual function.

CONCLUSIONS

Androgen replacement therapy, with DHEA, to menopausal women increases serum androgen levels without any appreciable effect on muscle cross-sectional area, muscle strength, muscle function, or improvement in health-related QOL.

Authors+Show Affiliations

Penn Fertility Care, Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15989411

Citation

Dayal, Molina, et al. "Supplementation With DHEA: Effect On Muscle Size, Strength, Quality of Life, and Lipids." Journal of Women's Health (2002), vol. 14, no. 5, 2005, pp. 391-400.
Dayal M, Sammel MD, Zhao J, et al. Supplementation with DHEA: effect on muscle size, strength, quality of life, and lipids. J Womens Health (Larchmt). 2005;14(5):391-400.
Dayal, M., Sammel, M. D., Zhao, J., Hummel, A. C., Vandenbourne, K., & Barnhart, K. T. (2005). Supplementation with DHEA: effect on muscle size, strength, quality of life, and lipids. Journal of Women's Health (2002), 14(5), 391-400.
Dayal M, et al. Supplementation With DHEA: Effect On Muscle Size, Strength, Quality of Life, and Lipids. J Womens Health (Larchmt). 2005;14(5):391-400. PubMed PMID: 15989411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supplementation with DHEA: effect on muscle size, strength, quality of life, and lipids. AU - Dayal,Molina, AU - Sammel,Mary D, AU - Zhao,Jing, AU - Hummel,Amy C, AU - Vandenbourne,Krista, AU - Barnhart,Kurt T, PY - 2005/7/2/pubmed PY - 2005/10/15/medline PY - 2005/7/2/entrez SP - 391 EP - 400 JF - Journal of women's health (2002) JO - J Womens Health (Larchmt) VL - 14 IS - 5 N2 - OBJECTIVE: To evaluate the effects of combination estrogen/androgen therapy on muscle mass, strength and endurance, serum hormone and lipid profiles, and quality of life measures in postmenopausal women. METHODS: Prospective, randomized, placebo-controlled pilot study at a tertiary care medical center. Fifty postmenopausal women were randomized to a 12-week course of (1) dehydroepiandrostenedione (DHEA) 50 mg daily, (2) conjugated equine estrogen (CEE) 0.625 mg daily, (3) DHEA 50 mg+CEE 0.625 mg daily, or (4) placebo. Main outcome measures of lower extremity muscle (calf) mass, functional muscle parameters, serum hormone and lipid levels, and quality of life (QOL) were obtained at baseline and after treatment. Statistical analysis compared percent change from baseline values and treatment differences among outcomes. RESULTS: Significant increases in mean DHEA, DHEA sulfate (DHEA-S), testosterone, and androstenedione levels were noted with DHEA alone or combined DHEA/CEE treatments when compared with placebo. Compared with no hormone therapy, none of the supplemental hormone groups caused significant changes in muscle mass, muscle strength, muscle endurance, feelings of well-being, sleep, or sexual function. CONCLUSIONS: Androgen replacement therapy, with DHEA, to menopausal women increases serum androgen levels without any appreciable effect on muscle cross-sectional area, muscle strength, muscle function, or improvement in health-related QOL. SN - 1540-9996 UR - https://www.unboundmedicine.com/medline/citation/15989411/Supplementation_with_DHEA:_effect_on_muscle_size_strength_quality_of_life_and_lipids_ L2 - https://www.liebertpub.com/doi/full/10.1089/jwh.2005.14.391?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -