Tags

Type your tag names separated by a space and hit enter

Alpha-helical CRH exerts CRH agonistic effects on sleep-endocrine activity in humans.
Neuropsychobiology. 2005; 52(2):62-7.N

Abstract

CRH is known to enhance wakefulness and to reduce SWS. In addition, some but not all, studies suggest that CRH promotes REM sleep. Alpha-helical CRH exerts CRH-antagonistic effects in various studies. We studied its effect on sleep EEG and nocturnal secretion of ACTH, cortisol, GH (n = 7) in young normal male subjects. After administering the substance cortisol and ACTH levels were enhanced during the total night compared to placebo. We found an increase of the time spent awake for the first half. ACTH (2nd half of the night) and cortisol (total night and 1st half of the night) increased. The results of the present study correspond to a mixture of agonistic and antagonistic effects of alpha-helical CRH.

Authors+Show Affiliations

Max-Planck-Institute of Psychiatry, Department of Psychiatry, Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15990457

Citation

Held, Katja, et al. "Alpha-helical CRH Exerts CRH Agonistic Effects On Sleep-endocrine Activity in Humans." Neuropsychobiology, vol. 52, no. 2, 2005, pp. 62-7.
Held K, Antonijevic I, Murck H, et al. Alpha-helical CRH exerts CRH agonistic effects on sleep-endocrine activity in humans. Neuropsychobiology. 2005;52(2):62-7.
Held, K., Antonijevic, I., Murck, H., Künzel, H., & Steiger, A. (2005). Alpha-helical CRH exerts CRH agonistic effects on sleep-endocrine activity in humans. Neuropsychobiology, 52(2), 62-7.
Held K, et al. Alpha-helical CRH Exerts CRH Agonistic Effects On Sleep-endocrine Activity in Humans. Neuropsychobiology. 2005;52(2):62-7. PubMed PMID: 15990457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alpha-helical CRH exerts CRH agonistic effects on sleep-endocrine activity in humans. AU - Held,Katja, AU - Antonijevic,Irina, AU - Murck,Harald, AU - Künzel,Heike, AU - Steiger,Axel, Y1 - 2005/06/29/ PY - 2005/7/2/pubmed PY - 2005/10/12/medline PY - 2005/7/2/entrez SP - 62 EP - 7 JF - Neuropsychobiology JO - Neuropsychobiology VL - 52 IS - 2 N2 - CRH is known to enhance wakefulness and to reduce SWS. In addition, some but not all, studies suggest that CRH promotes REM sleep. Alpha-helical CRH exerts CRH-antagonistic effects in various studies. We studied its effect on sleep EEG and nocturnal secretion of ACTH, cortisol, GH (n = 7) in young normal male subjects. After administering the substance cortisol and ACTH levels were enhanced during the total night compared to placebo. We found an increase of the time spent awake for the first half. ACTH (2nd half of the night) and cortisol (total night and 1st half of the night) increased. The results of the present study correspond to a mixture of agonistic and antagonistic effects of alpha-helical CRH. SN - 0302-282X UR - https://www.unboundmedicine.com/medline/citation/15990457/Alpha_helical_CRH_exerts_CRH_agonistic_effects_on_sleep_endocrine_activity_in_humans_ L2 - https://www.karger.com?DOI=10.1159/000086606 DB - PRIME DP - Unbound Medicine ER -