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Serum markers of inflammation and endothelial activation in children with obesity-related hypertension.
Neuro Endocrinol Lett. 2005 Jun; 26(3):242-6.NE

Abstract

OBJECTIVES

It has been suggested that a rise in blood pressure (BP) causes low-grade inflammation of the endothelium which, in turn, may be responsible for further damage of endothelium and worsening of BP control. The aim of the study was to evaluate serum levels of inflammation and endothelial activation markers in children with obesity-related hypertension and normotensive controls in relation to other traditional risk factors of arterial hypertension.

METHODS

Plasma insulin, glucose, C-reactive protein (CRP), fibrinogen (FB) interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and lipids levels were determined in 50 children with obesity-related hypertension and 143 obese children with normal BP. Insulin resistance was assessed by the homeostasis model.

RESULTS

Children with hypertension had significantly higher levels of all inflammatory markers as well as endothelial activation indices compared with normotensive subjects. In the stepwise regression model significant independent correlates for systolic BP were CRP, FB, VCAM-1, HOMA IR, LDL cholesterol and fat mass, whereas CRP, IL-6, ICAM-1, FB, LDL and HDL cholesterol were the determinants of diastolic BP in children with obesity-related hypertension.

CONCLUSION

These results indicate that low-grade inflammation and endothelial dysfunction are closely involved in the pathogenesis of obesity-related hypertension relatively early in life.

Authors+Show Affiliations

Independent Laboratory of Propedeutics of Chidren's Diseases, Pomeranian Medical University, Szczecin, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15990729

Citation

Garanty-Bogacka, Barbara, et al. "Serum Markers of Inflammation and Endothelial Activation in Children With Obesity-related Hypertension." Neuro Endocrinology Letters, vol. 26, no. 3, 2005, pp. 242-6.
Garanty-Bogacka B, Syrenicz M, Syrenicz A, et al. Serum markers of inflammation and endothelial activation in children with obesity-related hypertension. Neuro Endocrinol Lett. 2005;26(3):242-6.
Garanty-Bogacka, B., Syrenicz, M., Syrenicz, A., Gebala, A., Lulka, D., & Walczak, M. (2005). Serum markers of inflammation and endothelial activation in children with obesity-related hypertension. Neuro Endocrinology Letters, 26(3), 242-6.
Garanty-Bogacka B, et al. Serum Markers of Inflammation and Endothelial Activation in Children With Obesity-related Hypertension. Neuro Endocrinol Lett. 2005;26(3):242-6. PubMed PMID: 15990729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum markers of inflammation and endothelial activation in children with obesity-related hypertension. AU - Garanty-Bogacka,Barbara, AU - Syrenicz,Małgorzata, AU - Syrenicz,Anhelli, AU - Gebala,Aneta, AU - Lulka,Danuta, AU - Walczak,Mieczysław, PY - 2005/02/02/received PY - 2005/03/03/accepted PY - 2005/7/2/pubmed PY - 2005/10/6/medline PY - 2005/7/2/entrez SP - 242 EP - 6 JF - Neuro endocrinology letters JO - Neuro Endocrinol. Lett. VL - 26 IS - 3 N2 - OBJECTIVES: It has been suggested that a rise in blood pressure (BP) causes low-grade inflammation of the endothelium which, in turn, may be responsible for further damage of endothelium and worsening of BP control. The aim of the study was to evaluate serum levels of inflammation and endothelial activation markers in children with obesity-related hypertension and normotensive controls in relation to other traditional risk factors of arterial hypertension. METHODS: Plasma insulin, glucose, C-reactive protein (CRP), fibrinogen (FB) interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and lipids levels were determined in 50 children with obesity-related hypertension and 143 obese children with normal BP. Insulin resistance was assessed by the homeostasis model. RESULTS: Children with hypertension had significantly higher levels of all inflammatory markers as well as endothelial activation indices compared with normotensive subjects. In the stepwise regression model significant independent correlates for systolic BP were CRP, FB, VCAM-1, HOMA IR, LDL cholesterol and fat mass, whereas CRP, IL-6, ICAM-1, FB, LDL and HDL cholesterol were the determinants of diastolic BP in children with obesity-related hypertension. CONCLUSION: These results indicate that low-grade inflammation and endothelial dysfunction are closely involved in the pathogenesis of obesity-related hypertension relatively early in life. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/15990729/Serum_markers_of_inflammation_and_endothelial_activation_in_children_with_obesity_related_hypertension_ L2 - http://www.diseaseinfosearch.org/result/9028 DB - PRIME DP - Unbound Medicine ER -