Tags

Type your tag names separated by a space and hit enter

The Canadian Childhood Asthma Primary Prevention Study: outcomes at 7 years of age.
J Allergy Clin Immunol 2005; 116(1):49-55JA

Abstract

BACKGROUND

Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its development.

OBJECTIVE

The purpose of this study is to determine the effectiveness of a multifaceted intervention program for the primary prevention of asthma in high-risk infants at 7 years of age.

METHODS

Five hundred forty-five high-risk infants with an immediate family history of asthma and allergies were prospectively randomized into intervention or control groups prenatally. Intervention measures introduced before birth and during the first year of life included avoidance of house dust, pets, and environmental tobacco smoke and encouragement of breast-feeding with delayed introduction of solid foods. Assessment of outcomes at 7 years consisted of examination by pediatric allergists, methacholine inhalation tests, and allergy skin tests.

RESULTS

At 7 years, 469 of the 545 children were contacted, and 380 returned for further assessment. The prevalence of pediatric allergist-diagnosed asthma was significantly lower in the intervention group than in the control group (14.9% vs 23.0%; adjusted risk ratio, 0.44; 95% CI, 0.25-0.79). The prevalence of allergic rhinitis, atopic dermatitis, atopy (defined as positive skin test reactions to any common allergen), and bronchial hyperresponsiveness (defined as the provocative concentration of methacholine that induced a 20% decrease in FEV 1 from a postsaline value of less than 7.8 mg/mL) were not significantly different between the 2 groups. The prevalence of asthma (defined as wheeze without colds and the presence of bronchial hyperresponsiveness) was also significantly lower in the intervention group compared with the control group (12.9% vs 25.0%; adjusted risk ratio, 0.39; 95% CI, 0.22-0.71).

CONCLUSION

The multifaceted intervention program was effective in reducing the prevalence of asthma in high-risk children at 7 years of age.

Authors+Show Affiliations

Occupational and Environmental Lung Disease Unit, Department of Medicine. myeung@interchange.ubc.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15990772

Citation

Chan-Yeung, Moira, et al. "The Canadian Childhood Asthma Primary Prevention Study: Outcomes at 7 Years of Age." The Journal of Allergy and Clinical Immunology, vol. 116, no. 1, 2005, pp. 49-55.
Chan-Yeung M, Ferguson A, Watson W, et al. The Canadian Childhood Asthma Primary Prevention Study: outcomes at 7 years of age. J Allergy Clin Immunol. 2005;116(1):49-55.
Chan-Yeung, M., Ferguson, A., Watson, W., Dimich-Ward, H., Rousseau, R., Lilley, M., ... Becker, A. (2005). The Canadian Childhood Asthma Primary Prevention Study: outcomes at 7 years of age. The Journal of Allergy and Clinical Immunology, 116(1), pp. 49-55.
Chan-Yeung M, et al. The Canadian Childhood Asthma Primary Prevention Study: Outcomes at 7 Years of Age. J Allergy Clin Immunol. 2005;116(1):49-55. PubMed PMID: 15990772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Canadian Childhood Asthma Primary Prevention Study: outcomes at 7 years of age. AU - Chan-Yeung,Moira, AU - Ferguson,Alexander, AU - Watson,Wade, AU - Dimich-Ward,Helen, AU - Rousseau,Roxanne, AU - Lilley,Marilyn, AU - Dybuncio,Anne, AU - Becker,Allan, PY - 2005/7/2/pubmed PY - 2005/8/10/medline PY - 2005/7/2/entrez SP - 49 EP - 55 JF - The Journal of allergy and clinical immunology JO - J. Allergy Clin. Immunol. VL - 116 IS - 1 N2 - BACKGROUND: Avoidance of any one of the individual risk factors associated with childhood asthma has not been successful in preventing its development. OBJECTIVE: The purpose of this study is to determine the effectiveness of a multifaceted intervention program for the primary prevention of asthma in high-risk infants at 7 years of age. METHODS: Five hundred forty-five high-risk infants with an immediate family history of asthma and allergies were prospectively randomized into intervention or control groups prenatally. Intervention measures introduced before birth and during the first year of life included avoidance of house dust, pets, and environmental tobacco smoke and encouragement of breast-feeding with delayed introduction of solid foods. Assessment of outcomes at 7 years consisted of examination by pediatric allergists, methacholine inhalation tests, and allergy skin tests. RESULTS: At 7 years, 469 of the 545 children were contacted, and 380 returned for further assessment. The prevalence of pediatric allergist-diagnosed asthma was significantly lower in the intervention group than in the control group (14.9% vs 23.0%; adjusted risk ratio, 0.44; 95% CI, 0.25-0.79). The prevalence of allergic rhinitis, atopic dermatitis, atopy (defined as positive skin test reactions to any common allergen), and bronchial hyperresponsiveness (defined as the provocative concentration of methacholine that induced a 20% decrease in FEV 1 from a postsaline value of less than 7.8 mg/mL) were not significantly different between the 2 groups. The prevalence of asthma (defined as wheeze without colds and the presence of bronchial hyperresponsiveness) was also significantly lower in the intervention group compared with the control group (12.9% vs 25.0%; adjusted risk ratio, 0.39; 95% CI, 0.22-0.71). CONCLUSION: The multifaceted intervention program was effective in reducing the prevalence of asthma in high-risk children at 7 years of age. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/15990772/The_Canadian_Childhood_Asthma_Primary_Prevention_Study:_outcomes_at_7_years_of_age_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091674905006068 DB - PRIME DP - Unbound Medicine ER -