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The importance of alpha-fodrin antibodies in the diagnosis of Sjögren's syndrome.
Rheumatol Int. 2006 Feb; 26(4):354-9.RI

Abstract

OBJECTIVE

We wanted to determine the prevalence of IgA and IgG antibodies against alpha-fodrin in the patients with primary and secondary Sjögren's syndrome (SS) and also to compare with anti-Ro and anti-La antibodies in the diagnosis of SS.

METHODS

We tested the prevalence of anti-alpha-fodrin IgA, IgG, anti-Ro, anti-La antibodies, anti-nuclear antibodies (ANA) and rheumatoid factor (RF) in naive patients with primary (n = 20) and secondary SS (n = 20) (Rheumatoid Arthritis [RA]+SS, n = 10; Systemic Lupus Erythematosus [SLE] + SS, n = 10), RA (n = 10), SLE (n = 10) and in healthy controls (n = 20). Salivary gland biopsies were performed in the patients with primary and secondary SS.

RESULTS

In primary SS, anti-alpha-fodrin IgA, IgG, anti-Ro and anti-La antibodies were detected as 20, 10, 55 and 20% respectively. In RA + SS, anti-alpha-fodrin IgA was detected to be 10% and IgG was negative; however, anti-Ro antibodies and anti-La antibodies were found to be 40% and 20% respectively. In SLE + SS, anti-alpha-fodrin IgA was found to be 20% and IgG was found to be 10%, but anti-Ro and anti-La antibodies were found to be 90% and 20% respectively. Alpha-fodrin antibodies were not detected in RA, SLE and healthy controls.

CONCLUSION

The detection of anti-alpha-fodrin antibodies by used ELISA does not give much contribution to the diagnosis of SS, and anti-Ro and anti-La are still useful serological markers in the diagnosis of SS.

Authors+Show Affiliations

Department of Clinical Immunology and Rheumatology, Ankara University School of Medicine, 4. Sok. 22/50 Manolya Apt., Sogutozu, 06520 Ankara, Turkey. nurant@tr.netNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15990993

Citation

Turkçapar, Nuran, et al. "The Importance of Alpha-fodrin Antibodies in the Diagnosis of Sjögren's Syndrome." Rheumatology International, vol. 26, no. 4, 2006, pp. 354-9.
Turkçapar N, Olmez U, Tutkak H, et al. The importance of alpha-fodrin antibodies in the diagnosis of Sjögren's syndrome. Rheumatol Int. 2006;26(4):354-9.
Turkçapar, N., Olmez, U., Tutkak, H., & Duman, M. (2006). The importance of alpha-fodrin antibodies in the diagnosis of Sjögren's syndrome. Rheumatology International, 26(4), 354-9.
Turkçapar N, et al. The Importance of Alpha-fodrin Antibodies in the Diagnosis of Sjögren's Syndrome. Rheumatol Int. 2006;26(4):354-9. PubMed PMID: 15990993.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The importance of alpha-fodrin antibodies in the diagnosis of Sjögren's syndrome. AU - Turkçapar,Nuran, AU - Olmez,Umit, AU - Tutkak,Huseyin, AU - Duman,Murat, Y1 - 2005/07/01/ PY - 2004/09/29/received PY - 2005/01/30/accepted PY - 2005/7/2/pubmed PY - 2006/9/1/medline PY - 2005/7/2/entrez SP - 354 EP - 9 JF - Rheumatology international JO - Rheumatol Int VL - 26 IS - 4 N2 - OBJECTIVE: We wanted to determine the prevalence of IgA and IgG antibodies against alpha-fodrin in the patients with primary and secondary Sjögren's syndrome (SS) and also to compare with anti-Ro and anti-La antibodies in the diagnosis of SS. METHODS: We tested the prevalence of anti-alpha-fodrin IgA, IgG, anti-Ro, anti-La antibodies, anti-nuclear antibodies (ANA) and rheumatoid factor (RF) in naive patients with primary (n = 20) and secondary SS (n = 20) (Rheumatoid Arthritis [RA]+SS, n = 10; Systemic Lupus Erythematosus [SLE] + SS, n = 10), RA (n = 10), SLE (n = 10) and in healthy controls (n = 20). Salivary gland biopsies were performed in the patients with primary and secondary SS. RESULTS: In primary SS, anti-alpha-fodrin IgA, IgG, anti-Ro and anti-La antibodies were detected as 20, 10, 55 and 20% respectively. In RA + SS, anti-alpha-fodrin IgA was detected to be 10% and IgG was negative; however, anti-Ro antibodies and anti-La antibodies were found to be 40% and 20% respectively. In SLE + SS, anti-alpha-fodrin IgA was found to be 20% and IgG was found to be 10%, but anti-Ro and anti-La antibodies were found to be 90% and 20% respectively. Alpha-fodrin antibodies were not detected in RA, SLE and healthy controls. CONCLUSION: The detection of anti-alpha-fodrin antibodies by used ELISA does not give much contribution to the diagnosis of SS, and anti-Ro and anti-La are still useful serological markers in the diagnosis of SS. SN - 0172-8172 UR - https://www.unboundmedicine.com/medline/citation/15990993/The_importance_of_alpha_fodrin_antibodies_in_the_diagnosis_of_Sjögren's_syndrome_ L2 - https://dx.doi.org/10.1007/s00296-005-0607-9 DB - PRIME DP - Unbound Medicine ER -