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Efficacy of atovaquone and sulfadiazine in the treatment of mice infected with Toxoplasma gondii strains isolated in Brazil.
Parasite 2005; 12(2):171-7P

Abstract

The efficacy of atovaquone and sulfadiazine was examined alone or in combination for the treatment of mice infected with six Brazilian Toxoplasma gondii strains previously genotyped using the PCR-RFLP assays of the SAG2 gene, in addition to RH strain. Swiss mice were infected intraperitoneally with 10(2) tachyzoites from each strain of T. gondii and treated with 6.25, 12.5, 25 and 50 mg/Kg/day of atovaquone or 40, 80, 160 and 320 mg/Kg/day of sulfadiazine. In a second experiment, mice were treated with the association of previously determined doses of each drug. Treatment started 48 hours post-infection, and lasted 10 days. The susceptibility of T. gondii to atovaquone and to sulfadiazine was different according to the parasite strain. It was observed strains that are susceptible to atovaquone, and strains that are resistant to it. Type I strains were more susceptible to the activity of sulfadiazine and more resistant to atovaquone. Yet type III strains were susceptible to atovaquone and to sulfadiazine. Association of atovaquone and sulfadiazine presented a synergic effect in the treatment of mice infected with RH type I strain and an additive effect in the treatment of mice infected with one type I strain and with two type III strains.

Authors+Show Affiliations

Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627, Belo Horizonte, Minas Gerais, Brasil.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15991831

Citation

Alves, C F., and R W A. Vitor. "Efficacy of Atovaquone and Sulfadiazine in the Treatment of Mice Infected With Toxoplasma Gondii Strains Isolated in Brazil." Parasite (Paris, France), vol. 12, no. 2, 2005, pp. 171-7.
Alves CF, Vitor RW. Efficacy of atovaquone and sulfadiazine in the treatment of mice infected with Toxoplasma gondii strains isolated in Brazil. Parasite. 2005;12(2):171-7.
Alves, C. F., & Vitor, R. W. (2005). Efficacy of atovaquone and sulfadiazine in the treatment of mice infected with Toxoplasma gondii strains isolated in Brazil. Parasite (Paris, France), 12(2), pp. 171-7.
Alves CF, Vitor RW. Efficacy of Atovaquone and Sulfadiazine in the Treatment of Mice Infected With Toxoplasma Gondii Strains Isolated in Brazil. Parasite. 2005;12(2):171-7. PubMed PMID: 15991831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of atovaquone and sulfadiazine in the treatment of mice infected with Toxoplasma gondii strains isolated in Brazil. AU - Alves,C F, AU - Vitor,R W A, PY - 2005/7/5/pubmed PY - 2005/9/9/medline PY - 2005/7/5/entrez SP - 171 EP - 7 JF - Parasite (Paris, France) JO - Parasite VL - 12 IS - 2 N2 - The efficacy of atovaquone and sulfadiazine was examined alone or in combination for the treatment of mice infected with six Brazilian Toxoplasma gondii strains previously genotyped using the PCR-RFLP assays of the SAG2 gene, in addition to RH strain. Swiss mice were infected intraperitoneally with 10(2) tachyzoites from each strain of T. gondii and treated with 6.25, 12.5, 25 and 50 mg/Kg/day of atovaquone or 40, 80, 160 and 320 mg/Kg/day of sulfadiazine. In a second experiment, mice were treated with the association of previously determined doses of each drug. Treatment started 48 hours post-infection, and lasted 10 days. The susceptibility of T. gondii to atovaquone and to sulfadiazine was different according to the parasite strain. It was observed strains that are susceptible to atovaquone, and strains that are resistant to it. Type I strains were more susceptible to the activity of sulfadiazine and more resistant to atovaquone. Yet type III strains were susceptible to atovaquone and to sulfadiazine. Association of atovaquone and sulfadiazine presented a synergic effect in the treatment of mice infected with RH type I strain and an additive effect in the treatment of mice infected with one type I strain and with two type III strains. SN - 1252-607X UR - https://www.unboundmedicine.com/medline/citation/15991831/Efficacy_of_atovaquone_and_sulfadiazine_in_the_treatment_of_mice_infected_with_Toxoplasma_gondii_strains_isolated_in_Brazil_ L2 - http://publications.edpsciences.org/10.1051/parasite/2005122171 DB - PRIME DP - Unbound Medicine ER -