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Fetal programming of appetite by exposure to a maternal low-protein diet in the rat.
Clin Sci (Lond) 2005; 109(4):413-20CS

Abstract

Undernutrition in fetal life programmes risk of obesity and the metabolic syndrome in adult life. Rat studies indicate that exposure to a maternal low-protein diet throughout fetal life establishes a preference for high-fat foods. The present study aimed to assess the effect of low protein exposure during discrete 7-day periods of gestation upon feeding behaviour (full gestation 22 days). Pregnant rats were fed control or low-protein diet, with low-protein feeding targeted at day 0--7 (LP Early), day 8--14 (LP Mid) or day 15--22 (LP Late) of gestation. At 12 weeks of age, offspring were placed on a macronutrient self-selection regimen. Prenatal protein restriction programmed feeding behaviour in female, but not male, offspring. Among females, all low-protein exposed groups consumed less fat than the control group (P<0.05). Male offspring showed no changes in feeding behaviour. In males and females fed a low-fat chow diet, there were metabolic differences between the groups. LP Early and LP Late males had greater hepatic glycogen stores than control animals. There were no differences in the size of abdominal fat depots in either male or female rats exposed to low-protein diet at any point in gestation. The data suggest that programming of feeding behaviour is likely to be gender-specific and dependent upon the timing of nutrient insult in fetal life. This work may have implications for the development of the metabolic syndrome.

Authors+Show Affiliations

School of Biosciences, University of Nottingham, Sutton Bonington, Loughborough LE12 5RD, U.K.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15992360

Citation

Bellinger, Leanne, and Simon C. Langley-Evans. "Fetal Programming of Appetite By Exposure to a Maternal Low-protein Diet in the Rat." Clinical Science (London, England : 1979), vol. 109, no. 4, 2005, pp. 413-20.
Bellinger L, Langley-Evans SC. Fetal programming of appetite by exposure to a maternal low-protein diet in the rat. Clin Sci. 2005;109(4):413-20.
Bellinger, L., & Langley-Evans, S. C. (2005). Fetal programming of appetite by exposure to a maternal low-protein diet in the rat. Clinical Science (London, England : 1979), 109(4), pp. 413-20.
Bellinger L, Langley-Evans SC. Fetal Programming of Appetite By Exposure to a Maternal Low-protein Diet in the Rat. Clin Sci. 2005;109(4):413-20. PubMed PMID: 15992360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fetal programming of appetite by exposure to a maternal low-protein diet in the rat. AU - Bellinger,Leanne, AU - Langley-Evans,Simon C, PY - 2005/7/5/pubmed PY - 2005/12/15/medline PY - 2005/7/5/entrez SP - 413 EP - 20 JF - Clinical science (London, England : 1979) JO - Clin. Sci. VL - 109 IS - 4 N2 - Undernutrition in fetal life programmes risk of obesity and the metabolic syndrome in adult life. Rat studies indicate that exposure to a maternal low-protein diet throughout fetal life establishes a preference for high-fat foods. The present study aimed to assess the effect of low protein exposure during discrete 7-day periods of gestation upon feeding behaviour (full gestation 22 days). Pregnant rats were fed control or low-protein diet, with low-protein feeding targeted at day 0--7 (LP Early), day 8--14 (LP Mid) or day 15--22 (LP Late) of gestation. At 12 weeks of age, offspring were placed on a macronutrient self-selection regimen. Prenatal protein restriction programmed feeding behaviour in female, but not male, offspring. Among females, all low-protein exposed groups consumed less fat than the control group (P<0.05). Male offspring showed no changes in feeding behaviour. In males and females fed a low-fat chow diet, there were metabolic differences between the groups. LP Early and LP Late males had greater hepatic glycogen stores than control animals. There were no differences in the size of abdominal fat depots in either male or female rats exposed to low-protein diet at any point in gestation. The data suggest that programming of feeding behaviour is likely to be gender-specific and dependent upon the timing of nutrient insult in fetal life. This work may have implications for the development of the metabolic syndrome. SN - 0143-5221 UR - https://www.unboundmedicine.com/medline/citation/15992360/Fetal_programming_of_appetite_by_exposure_to_a_maternal_low_protein_diet_in_the_rat_ L2 - http://clinsci.org/cgi/pmidlookup?view=long&amp;pmid=15992360 DB - PRIME DP - Unbound Medicine ER -