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Circulating activated T lymphocytes in autoeczematization.
Arch Dermatol. 1992 Jun; 128(6):795-8.AD

Abstract

BACKGROUND AND DESIGN

Autoeczematization, the symmetric diffuse spread of a previously localized dermatitis, has an unclear etiology although some investigators have postulated that activated T lymphocytes play a role. Two estimates of activation of peripheral T lymphocytes are the cell surface expression of the HLA-DR antigen and the interleukin 2 receptor (IL-2R). We measured the percentage of circulating activated T lymphocytes in nine patients with autoeczematization compared with normal controls (n = 10), patients with stasis dermatitis (n = 6), and patients with severe (n = 10) or mild (n = 8) psoriasis. The percentage of activated T lymphocytes was determined by fluorescent, activated cell sorter analysis of peripheral leukocytes doubly stained with antibodies to T lymphocytes and HLA-DR antigen or IL-2R.

RESULTS

Statistically significant elevations of HLA-DR- and IL-2R--positive T lymphocytes were seen in autoeczematization patients (P less than .004 and P less than .04, respectively) and those with severe psoriasis (P less than .004 for HLA-DR antigen and IL-2R). Percentages of HLA-DR- and IL-2R--positive T lymphocytes in patients with mild psoriasis were not significantly elevated. Two patients with autoeczematization had a reduction of their previously elevated levels of HLA-DR- and IL-2R--positive T lymphocytes after treatment.

CONCLUSIONS

These data suggest a possible role for circulating activated T lymphocytes in the pathogenesis of autoeczematization and possibly in severe psoriasis.

Authors+Show Affiliations

Department of Internal Medicine, Salt Lake City Veterans Affairs Medical Center, UT.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1599265

Citation

Kasteler, J S., et al. "Circulating Activated T Lymphocytes in Autoeczematization." Archives of Dermatology, vol. 128, no. 6, 1992, pp. 795-8.
Kasteler JS, Petersen MJ, Vance JE, et al. Circulating activated T lymphocytes in autoeczematization. Arch Dermatol. 1992;128(6):795-8.
Kasteler, J. S., Petersen, M. J., Vance, J. E., & Zone, J. J. (1992). Circulating activated T lymphocytes in autoeczematization. Archives of Dermatology, 128(6), 795-8.
Kasteler JS, et al. Circulating Activated T Lymphocytes in Autoeczematization. Arch Dermatol. 1992;128(6):795-8. PubMed PMID: 1599265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating activated T lymphocytes in autoeczematization. AU - Kasteler,J S, AU - Petersen,M J, AU - Vance,J E, AU - Zone,J J, PY - 1992/6/1/pubmed PY - 1992/6/1/medline PY - 1992/6/1/entrez SP - 795 EP - 8 JF - Archives of dermatology JO - Arch Dermatol VL - 128 IS - 6 N2 - BACKGROUND AND DESIGN: Autoeczematization, the symmetric diffuse spread of a previously localized dermatitis, has an unclear etiology although some investigators have postulated that activated T lymphocytes play a role. Two estimates of activation of peripheral T lymphocytes are the cell surface expression of the HLA-DR antigen and the interleukin 2 receptor (IL-2R). We measured the percentage of circulating activated T lymphocytes in nine patients with autoeczematization compared with normal controls (n = 10), patients with stasis dermatitis (n = 6), and patients with severe (n = 10) or mild (n = 8) psoriasis. The percentage of activated T lymphocytes was determined by fluorescent, activated cell sorter analysis of peripheral leukocytes doubly stained with antibodies to T lymphocytes and HLA-DR antigen or IL-2R. RESULTS: Statistically significant elevations of HLA-DR- and IL-2R--positive T lymphocytes were seen in autoeczematization patients (P less than .004 and P less than .04, respectively) and those with severe psoriasis (P less than .004 for HLA-DR antigen and IL-2R). Percentages of HLA-DR- and IL-2R--positive T lymphocytes in patients with mild psoriasis were not significantly elevated. Two patients with autoeczematization had a reduction of their previously elevated levels of HLA-DR- and IL-2R--positive T lymphocytes after treatment. CONCLUSIONS: These data suggest a possible role for circulating activated T lymphocytes in the pathogenesis of autoeczematization and possibly in severe psoriasis. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/1599265/Circulating_activated_T_lymphocytes_in_autoeczematization L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/128/pg/795 DB - PRIME DP - Unbound Medicine ER -